GABA and you

GABA is a naturally occurring amino acid, found in the brain and the body. It is one of a class of inhibitory neurotransmitters that include serotonin. Although it is classed as an inhibitor rather than a stimulator its definition is only one of electrochemical activity in the brain and should not be interpreted as a downer or sedative - just the term neurotransmitter defines its ability as a natural substance that helps nerve impulses cross synapses and communicate with one another.

GABA usage will stimulate the release by the pituitary gland of Human Growth Hormone (HGH) (or Growth Hormone (GH)) which is naturally released by the body when it undergoes vigorous peak muscular exercise, during certain phases of sleep, or restricted food intake. The growth hormone is produced by the pituitary gland, located at the base of the brain. Even small doses (2-5 grams) can increase circulating growth hormone by more than 5 times its normal levels.

GH stimulates growth and repair of the body as well as the activities of the immune system. The immune system is run down by excess exercise without the proper nutrition. GH also helps the body burn fat and convert it into energy and muscle and aids in wound healing and tissue repair. GH is widely known for its powerful anabolic (muscle building) effects as well as its lipotropic (breakdown and utilization of body fat) effects. The overall result of these effects is an increase in lean tissue mass and a decrease in body fat. Finally, stimulating naturally the levels of GH leads to greater feelings of energy and vigour.

Additionally, GABA has been shown to have positive toning effects on the nervous system, to improve sleep cycles leading to more restful sleep and more interesting lucid dreaming, to have a powerful stabilising effect on blood pressure and to be an effective analgesic (removing the perception of pain).

GABA is a very safe supplement and can be used daily. GABA has also been shown to act as a powerful natural analgesic through its stimulation of the brain’s release of endorphins.

Based upon the scientific evidence, a combination of GABA and exercise would have the best effect on stimulating the natural secretion of growth hormone. Resulting in better utilization of stored fat, an increase in firm, lean tissue and a more healthy, shapely body!

Many of these effects are also to be gained by other components of the supplement and are thus reinforced. The dosage is low as the components are working together and there is a natural overall effect of body stimulation leading to more energy.

*(Credit for the above goes to 8 isn’t enough from MOS)*

Several amino acids have distinct excitatory or inhibitory effects upon the nervous system. The amino acid derivative, g-aminobutyrate, also called 4-aminobutyrate, (GABA) is a well-known inhibitor of presynaptic transmission in the CNS, and also in the retina. The formation of GABA occurs by the decarboxylation of glutamate catalyzed by glutamate decarboxylase (GAD). GAD is present in many nerve endings of the brain as well as in the b-cells of the pancreas. Neurons that secrete GABA are termed GABAergic.

GABA exerts its effects by binding to two distinct receptors, GABA-A and GABA-B. The GABA-A receptors form a Cl- channel. The binding of GABA to GABA-A receptors increases the Cl- conductance of presynaptic neurons. The anxiolytic drugs of the benzodiazepine family exert their soothing effects by potentiating the responses of GABA-A receptors to GABA binding. The GABA-B receptors are coupled to an intracellular G-protein and act by increasing conductance of an associated K+ channel.

I was very interested in this supplement and wanted to know if any one here had tried it. I am going on a shopping spree at the vitamen store tomorrow. I may pick it up or not. I have to control my gout first. I have even heard that this stuff helps you kick smoking. So it looks to be something of interest for me. I am really looking forward to the anti-anxiety effects. I am too tightly wrapped at the moment to not chain smoke and worry over things so this should help me.

If you have any information either pro or con, I would love to hear it. Any questions maybe one of the resident chem wizards or fitness gurus could tell us a thing or two.

Now my question would be that if this stuff increases collagen production and or strength would this not be the exact opposite of what we want with PE and hanging in particular? If I am wrong please correct me, I learn something new each day.

If it is true that GABA increases natural gH production it sould be an aid for penile growth, weight loss and body building. I think I’ll look into it.

>*(Credit for the above goes to 8 isn’t enough from MOS)*

Oops! Oh well just trying to be civil to the dude who started a thread on this stuff. I debated searching for a good text, but alas I always find shit way to technical for anyone.

But if hGH is good for Pe in General isn’t it bad for hanging by strengthening collagen?

I know this twat,

acromegalics have enlargement of ears, nose, hands, head, feet, and yes penis.

I doubt GABA does much of anything. If it truly increased GH and/or had positive effects on body composition or recovery, bodybuilders would be all over it. They aren’t.

But yeah, if something aids collagen repair it probably isn’t conducive to gains from hanging.

*Acta Endocrinol (Copenh) 1980 Feb;93(2):149-54 (ISSN: 0001-5598)
Cavagnini F; Invitti C; Pinto M; Maraschini C; Di Landro A; Dubini A; Marelli A

A single oral dose of 5 g gamma aminobutyric acid (GABA) was given to 19 subjects and serial venous blood samples were obtained before and 3 h after drug administration. A placebo was administered to 18 subjects who served as controls. GABA caused a significant elevation of plasma growth hormone levels (P less than 0.001), but did not consistently alter plasma prolactin concentration since only 5 out of 15 subjects showed an increase of the hormone. Eight additional subjects were submitted to an insulin tolerance test before and after per os administration of 18 g GABA daily for 4 days. Protracted GABA treatment significantly blunted the response of growth hormone and enhanced that of prolactin to insulin hypoglycaemia (P less than 0.01). These results indicate that pharmacological doses of GABA affect growth hormone and prolactin secretion in man. The precise nature of GABA’s effects as well as its mechanism of action remains to be clarified.

* Courteousy of Medline. Full text available through mail-order or your University library.

Ah, acromegliacs the GQ models of very tall people. ;) Unfortunately, I have that common every day non acromegliac appearence. No wonder my dick is small. Oh well.

Side question, does acromeglia automatically give you a deeper voice? All those afflicted seem to have super deep voices. One girl I knew, used to date the dude who had the world’s biggest foot. His voice was incredibly deep and you could tell he suffered from it just by looking at him. He is now on that HBO Carnivale show.

Here is some more info about GABA.

And the below from:

Obvoiusly, this guy is mistaken. I have already posted the study on the increase of GH.

Edit: No need to post anymore about this point. I’m at work and should be working..lol

But feel free Hobby to post his information. He based his Gh opinion on this Study.

12. Vescovi PP, Di Gennaro C. Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts. Neuropeptides. 1997 Oct;31(5):459-62.

Why in hell is he comparing the results of cocaine addicts to average people? HOMEWORK, HOMEWORK, HOMEWORK.

Dont worry, I’ll email the guy and set him straight. Poor mislead dude.

I’ve taken GABA. It has seemingly helped with gaining muscle but I havn’t noticed any measurable improvements with PE.

BB,

Are you hanging when taking this? Just curious. I would take it just to calm me. I am a little tweaked right now. Just my anxiety of course.

If it allows me to get the equivalent of 8 hours in 6 it has me sold.

TT,

Nope, never hanged (hung?). I do Horse440s all day and gain length but no girth. *shrug*

I havn’t noticed any sleep benefits from GABA but I never sleep anyway.