Green tea vs premature ejaculation.

Green tea may block activity of common cancer drug
Fri, Feb 13, 2009
Reuters

NEW YORK (Reuters Health) - Some components of green tea may counteract the beneficial effects of a widely used anti-cancer agent called Velcade, also known as bortezomib.

“We know that cancer patients look to green tea extracts among other natural supplements to complement their therapeutic regimens,” Dr. Axel Schonthal, said in a statement. “We wanted to better understand how the compounds in green tea interact with a cytotoxic chemical therapy and how that may affect patient outcomes.”

In lab studies, Schonthal, from the University of Southern California Keck School of Medicine, Los Angeles, and colleagues evaluated the impact of green tea compounds on the efficacy of bortezomib against multiple myeloma, a blood cancer, and glioblastoma, a malignant brain tumor.

Bortezomib normally fights cancer by inducing tumor cell death. However, Schonthal and colleagues were surprised to find that some of the green tea polyphenols and other components actually prevented bortezomib from killing tumor cells.

“Our surprising results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of bortezomib,” Schonthal said.

“The current evidence,” Schonthal said, “is sufficient enough to strongly urge patients undergoing bortezomib therapy to abstain from consuming green tea products, particularly the widely available, highly concentrated green tea and EGCG (epigallocatechin gallate) products that are sold in liquid or capsule form.”

The findings of this study, the investigators emphasize, are specific for patients taking bortezomib as opposed to any other common cancer drug.

“Although the study has exposed detrimental effects of great tea in specific combination with Velcade, this should not minimize the previously reported potentially beneficial effect of this herb,” Schonthal said. “Related studies with other types of cancer therapies are promising and green tea extract may actually improve the anticancer effects of other drugs.”

SOURCE: Blood, online February 3, 2009.

Cancer fighting green tea may have a dark side
By Janet Raloff
Web edition : Thursday, February 5th, 2009
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For more than a decade, study after study has extolled the cancer-fighting virtues of green tea, or at least extracts of its polyphenol antioxidants. But preliminary data now suggest that for some people this herbal remedy may not prove beneficial — or even benign. In test-tube experiments on cancer cells and in animals, green tea’s polyphenols inactivated the cell-killing activity of a drug used to treat blood cancers.

Physicians prescribe bortezomib, a drug sold under the trade name Velcade, to patients with multiple myeloma. This treatable, though incurable, cancer begins in antibody-producing white blood cells. As the abnormal cells replicate and build within bone marrow, they risk damaging the bone itself. Once this disease spreads to marrow-producing tissue at several sites in the body, it’s termed multiple myeloma. Infections, liver failure and death can result.

Bortezomib is also approved for treatment of mantle cell lymphoma, a rare and hard-to-cure form of non-Hodgkin’s disease.

Buoyed by all of the benefits ascribed to green-tea polyphenols — particularly (-)-epigallocatechin gallate, better known as EGCG — a Los Angeles-based team of researchers decided to treat multiple myeloma with bortezomib in combination with various green-tea polyphenols, especially EGCG. The pharmacologists had anticipated the drug-tea duo would dramatically outperform use of bortezomib alone. In fact, the pairing totally shut down the drug’s anticancer activity.

The findings appear in Blood, a journal of the American Society of Hematology, which published the new green-tea paper early online, this week, ahead of print.

That EGCG “blocked the therapeutic action of Velcade was completely unexpected,” according to team leader Axel H. Schönthal of the University of Southern California School of Medicine.

As a so-called proteasome inhibitor, bortezomib deactivates proteasomes —large protein complexes that help destroy cellular proteins that have outlived their usefulness. In the test-tube and in mice, EGCG and its polyphenolic kin blocked the cancer drug’s proteasome inhibition. A key constitutent of the drug is boron. And that’s proved interesting, Schönthal’s team notes, because they observed no green-tea inactivation of cancer-fighting proteasome inhibitors that lack boron.

Other dietary constituents — most notably vitamin C and iron — can also poison the activity of bortezomib, but only at concentrations 100-fold higher than EGCG requires. In fact, EGCG concentrations needed to turn off the drug’s anticancer activity in the latest study “can easily be achieved [in people] after the ingestion of capsules containing green-tea extract,” Schönthal and his colleagues report. “We therefore have no doubt that our discovery is highly relevant for clinical considerations.”

“The most immediate conclusion,” Schönthal says, is that “patients undergoing cancer therapy with Velcade must avoid green tea, and in particular all of its concentrated [polyphenol extracts]” that are so readily available in health-food stores and online.

Adding to Schönthal’s concerns: Green-tea supplements may provide symptomatic relief for some patients treated with bortezomib — precisely because the tea constituents are turning off the cell-poisoning activity responsible for triggering side effects.

But don’t look for a simple message in this research, such as that green tea is bad for chemotherapy patients. In a separate study using another “well-established chemotherapeutic drug” — one that Schönthal won’t yet name — “inclusion of EGCG appears to yield an ‘encouragingly beneficial’ outcome.”

The Multiple Myeloma Research Foundation provided funding for the new study.

This is good to know in this ongoing information gathering thread on green tea.

Hey guys, I’m 23 and have had PE ever since I could cum. I have hardly any control and have tried a number of different methods without much success. I’m living in China for the year and after seeing this thread I got the idea to down a couple cups of green tea and watch a porno. I don’t want to get my hopes up, but it seemed it did give me more sexual control and slightly lessened the sensitivity of my hyper-sensitive dick. I typically cum very fast while watching porn and even faster during sex. I’ll keep experimenting with it this week and see what happens.

1 You have to learn to control yourself mentally and physically. By saying that I mean

1a control your urge to watch porn and sex is not ejaculation. Bring your anxiety under control

1b learn to relax you pelvic floor, leg and lower back muscles where tension builds up and the urge of ejaculation is first formed

2 Have some herbal teas(Chinese herbalists) to relax your central nervous system

3 have lost of foreplay with your lady to learn all about her body and yourself

Green tea contain just about half the caffeine of black tea so is not a good idea for you to have it anyway