Originally Posted by Doinitforlove
“IGF-1 acts on several different tissues to enhance growth. IGF1 belongs in the ’superfamily’ of substances known as ‘growth factors,’ along with epidermal (skin), transforming; platelet derived fibroblast, nerve, and ciliary neurotrophic growth factors. None of the other factors have any bearing on exoskeletal tissue incidentally however These agents all have in common the ability to stimulate cell division, known as mitogenesis, and cell differentiation.”Above is a snippet of info I noticed whilst looking at Revitropin (IGF-1 Long R3) on a site owned by a company called Neo Genica (just google search revitropin).
After doing a search on threads with IGF-1 mentioned I found that the general perception about its relation to PE was that it only stimulates muscular hyperplasia (an actual splitting of cells rather than a mere swelling or hypertrophy). The above quote I pasted seems to suggest otherwise.
Another quote,
“Every thing IGF1 touches will grow”
Now it’s certainly clear that it’s easy for me to highlight the more desirable sounding, claimed, effects and I can pretty much guarantee that those who read about it will notice some not so desirable side effects that comes with the drug. I’m also not simply saying “Take this wonder drug and without any other effort your unit will grow.” I would just like for a few of the members who are more experienced than me to cross examine the above quotes and still tell me that IGF-1 could never be utilised as an effective supplement to fully recover, repair and even help to split and create new cells within the anatomy of the penis after working out.
With a lot more research carried out by myself on this product I basically looking to inject this stuff as close to my dick as possible. The site suggests that you inject subcutaneously into the abdominal fat tissue. I was thinking more along the line of injecting it into the pubic bone fat pad.
Any views?
Thanks
I’ve already discussed this here somewhere. IGF is site specific for growth, but also has systemic effect. The MAIN issue with IGF is the acetic acid that is used to reconstitute the IGF-1. It BURNS like hell. And causes bruising and can cause necrosis of tissue.
I am using IGF-1, PEG MGF and GH as we speak.
My muscle growth is through the roof.
IF you plan on using IGF-1 take 50 MCG’s (notice that is MCG NOT mG’s which is miligrams) 3 times per week.
25mcg’s injected bilaterally into the shaft itself, BUT you must buy the kits that have 100mcg’s in each syringe because you can then reconstitute the IGF with bacteriostatic water and not AA.
Bottom line is IGF1 and PEG MGF (pegylated Mechano Growth Factor) both work to form NEW cells.
“From its sequence, MGF is derived from the IGF-I gene by alternative splicing and has different 3’ exons to the liver or systemic type (IGF-IEa). It has a 49 base pair insert in the human, and a 52 base pair insert in rodents, within the E domain of exon 5. This insert results in a reading frame shift, with a different carboxy (C) terminal sequence to that of systemic IGF-IEa. MGF and the other IGF isoforms have the same 5’ exons that encode the IGF-I ligand-binding domain. Processing of pro-peptide yields a mature peptide that is involved in upregulating protein synthesis. However, there is evidence that the carboxy-terminal of the MGF peptide also acts as a separate growth factor. This stimulates division of mononucleated myoblasts or satellite (stem) cells, thereby increasing the number available for local repair
During the early stage of skeletal muscle development, myoblasts (muscle stem cells) fuse to form syncytial myotubes, which become innervated and develop into muscle fibres. Thereafter, mitotic proliferation of nuclei within the muscle fibres ceases. However, during postnatal (after development) growth, additional nuclei are provided by satellite cells (myoblast) fusing with myotubules. Muscle damage-recovery seems to have a similar cellular mechanism, in that satellite cells become activated and fuse with the damaged muscle fibres (reviewed by Goldring et al. 2002). This is also pertinent to certain diseases such as muscular dystrophy in which muscle tissue is not maintained and which have been associated with a deficiency in active satellite (stem) cells (Megeney et al. 1996; Seale & Rudnicki, 2000) and in myogenic factors (Heslop et al. 2000). Skeletal muscle mass and regenerative capacity have also been shown to decline with age (Sadeh, 1988; Carlson et al. 2001). The reduced capacity to regenerate in older muscle seems to be due to the decreased ability to activate satellite cell proliferation (Chakravarthy et al. 2000). The markedly lower expression of MGF in older rat muscles (Owino et al. 2001) and human muscle (Hameed et al. 2003) in response to mechanical overload has been associated with the failure to activate satellite cells, leading to age-related muscle loss (Owino et al. 2001). Your muscle cels can not grow once they have reached a certain size unless they obtain more nuclei from the myoblast. MGF increases the myblast available to donate their nuclei to the adult muscle cell.
“MGF appears to have a dual action in that, like the other IGF-I isoforms, it upregulates protein synthesis as well as activating satellite cells. However, the latter role of MGF is probably more important as most of the mature IGF-I will be derived from IGF-IEa during the second phase of repair. Nevertheless, it has been shown that MGF is a potent inducer of muscle hypertrophy in experiments in which the cDNA of MGF was inserted into a plasmid vector and introduced by intramuscular injection. This resulted in a 20 % increase in the weight of the injected muscle within 2 weeks, and the analyses showed that this was due to an increase in the size of the muscle fibres (Goldspink, 2001). Similar experiments by other groups have also been carried out using a viral construct containing the liver type of IGF-I, which resulted in a 25 % increase in muscle mass, but this took over 4 months to develop (Musaro et al. 2001). Hence, the dual role MGF plays in inducing satellite cell activation as well as protein synthesis suggests it is much more potent than the liver type or IGF-IEa for inducing rapid hypertrophy.”
These results are based on actual transplantation of the DNA coding for the peptides. This is a permanent effect and much more potent than IM injections of the peptide itself. You will not see a 20% increase in muscle mass through IM injections as claimed above.
The PEGylated version is going to be much longer lasting making a 1-2 dose per week procedure possible. I still think its best used with IGF or AAS to maximize the benefits so here are some sample protocols
Once a week PEG MGF/ IGF
Sunday 100-300 mcg MGF you can choose to site inject if you wish. I think splitting large doses may benefit.
Monday –Fri IGF 50mcg e/d
Twice a week PEG MGF / IGF
Sunday and Wed MGF 50-150 mcg
MT, ThF IGF 50 mcg
