L-Deprenyl/Selegiline

I’ve just purchased a pack of these from ADC. I’m 25 years old and had been lead to believe there wouldn’t be much of a noticable effect.

After 10mg yesterday and 2.5mg today I feel fantastic, energy levels increased, increased libido, crystal clear thoughts, mood elevation. Just wondering if anyone has had a similar experience? I would definitely recommend trying them - just remember to keep the dosage low to get MAOB-I specifically and not the more generalised MAOA-I at higher doses.

Could be placebo I know, but if it is, i’m not complaining :)

10mg!! on the first day!! ok.. Might wanna tone it down to 2.5 a day for the first week or two. 10mg is getting close to the point it stops being selective and starts on serotonin..

And no, I also have the same effect on 2.5 a day, have been on it for around 6 months now and wouldn’t consider getting off them. Originally my reasons had more to do with it’s dopamine receptor protective effects etc. However have found that the mood enhancing qualities add an extra benefit.

I’d be interested in trying the patches (Emsam) as I have suffered from major depression for a long time.

I wonder if it would have an effect on anxiety?

I read that 10mg is required to inhibit 98% of MAOB, so I thought i’d jump right in, then reduce my dosage to maintain the level in the weeks to come.

Tossed Salad:

I know that due to its metabolites L-Deprenyl has some norepinephrine enchancing side-effects which in some people can cause anxiety. Personally i’m an anxious person and right now I just feel too damn hyped to feel anxious in the slightest.

Have you had experience with other anti-depressants before?

One thing I’m looking at is the MAOI diet that typically goes with this medication: No cheese, No red wine, No salami.

Damn.

The diet isn’t required when using the patch as it bypasses your digestive system. Additionally if you’re taking a low dose (a lot of people see great results on 2.5mg - 5mg 3 times a week) There’s no need for any special diet as MAOB inhibitation has little effect on tyramine (the cause of cheese syndrome)

http://www.selegiline.com/

Is a great website to take a look at.

I took SJW for a long period of time with some great results, however it did reduce my libido somewhat. I’m currently intending to combine 500-1000mg of L-Tryptophan daily with a 2.5mg 3 times a week course of L-Deprenyl; I’m trying to find a solution to my mild depression/social phobia (i’m not a recluse) but on a bad day social interaction can make me quite edgy.

What is ADC? Do you experience the multiorgasmic effect?

Alldaychemist and no I haven’t experienced that. Ongoing I feel more focused, libido slightly improved, happier, it’s disturbed my sleeping pattern slightly, but that’s easy to tackle with melatonin.

If you want an extreme and almost God-like dopamine rush, I suggest taking 800mg of Piracetam 3x a day and 400mg of Alpha-GPC once a day with L-Deprenyl.

It had me pacing around my house unable to stay still, thoughts rushing, but with a fair degree of clarity still, rather than the fog normally associated with such levels of stimulation.

Remember that whenever we take such drugs we act against “natural balance”. I have tried it. Be advised that if you elevate dopamine levels(and this is what happens to you now) your serotonin levels are relatively low due to this. After prolonged period of time you can become anxious and nervous.

Besides it is easy to get used to low doses(BTW - you should have started with 2.5) and you have to up the dosage after some time.

Also - high level of dopamine makes one ejaculate easy. This can lead in extreme cases to premature ejaculation. Funny thing - people who take opposite drugs(like SSRI) to cure “premature ejaculation” often lose so much of libido that they are later advised to take Deprenyl to elevate dopamine levels(because high serotonin levels decrease dopamine - it is just opposite in your case)

I tried it. Left it. Balance of chemistry in the brain is much more important for me now.

I agree with you. Messing with dopamine system is kind of skating on thin ice regarding healthy brain chemistry. I tried dostinex which raises dopamine levels and even it did made me hornier, the side effects were not worth it(feeling anxious, vidid nightmare and increased irritability).

I didn’t try deprenyl but if it’s short acting then you can have it on your days when you want to enhance yourself. And regarding the serotonin/dopamine system in orgasm/ejaculation I would like to say that even if maybe raising dopamine levels makes you cum quicker(I don’t remember , if it did or not), the refractory period is shorter due to dopamine lowering prolactin levels and you’re ready to go in no time.

Be careful with selegiline dosing. At low doses it should only lower MAO-B levels so you still have MAO-A to break down tyramine, but taken over longer periods of time it can also start to inhibit MAO-A.

I’ve just been reading about an Oxytocin nasal spray and apparently it’s great for people who are shy or socially inhibited.

Has anyone noticed any longer lasting power, mediated by the MAOA-I effects, at higher doses? Also, what vascular effects have you noticed? E.g., blood pressure changes, blood flow, high NE feelings, etc.

THIS is EXACTLY what I’m looking for. My lovers complain that I take too long. If I’m wearing a condom, it is near impossible for me to climax.

Any suggestions as to raising my dopamine levels?

This isn’t correct. It’s epinephrine binding to adrenergic receptors.