PE, Nitric Oxide increasing supplements, ischemia, and reperfusion injury

I’ve long been into taking arginine and NO producing supplements. However I found some info in my research that I wanted to present here, and see some other peoples opinions on it.

First of all, ischemia is the restriction of blood supply to part of the body.

"Reperfusion injury refers to damage to tissue caused when blood supply returns to the tissue after a period of ischemia. The absence of oxygen and nutrients from blood creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than restoration of normal function." - Reperfusion injury - Wikipedia

"Nitric oxide can contribute to reperfusion injury when an excessive amount produced during reperfusion (following a period of ischemia) reacts with superoxide to produce the damaging free radical peroxynitrite." - Nitric oxide - Wikipedia

So although it has a lot of great things about it, like giving us better blood flow (IE erections), raising HGH etc. it could be bad for PEers. If you hang or clamp, you are cutting off the blood flow to some degree causing ischemia.

"Restoration of blood flow after a period of ischemia can actually be more damaging than the ischemia. Reintroduction of oxygen causes a greater production of damaging free radicals, resulting in reperfusion injury. With reperfusion injury, necrosis can be greatly accelerated." - Ischemia - Wikipedia

Perhaps this is a good reason NOT to do light jelqs between hang sessions or clamping, by doing so you are bringing in the blood faster and increasing reperfusion injury potential.

Just a thought, I’d like anyone else’s input.

Alpha lipoic acid (ALA) plus vitamin C scavenges peroxynitrites. I think you need to take very large doses of ALA though. Like 600mg.

I think you can PE without ischemia, especially without ischemic damage.

Some exercises, clamping for example, can cause reduction in circulation, but that does not mean ischemia. Blood trapped in the penis during these exercises is oxygenated, and the logic for taking frequent breaks is to allow a regular replacement of oxygenated blood for the stagnant blood, before depleting all the oxygen.

I haven’t heard of re-perfusion injury. I’ll have to do some reading. After ischemia, you obviously need oxygenated blood, so wouldn’t the accompanying oxidatitive reactions be a necessary evil?

That makes sense.

Also you may want to flush the system with 02 first, before going to arginine. Recover in stages rather than all at once. An example of this would be to do gensing therapy first or ginkgo. Something that increases 02 saturation. I used Gensing and iron supplements to recover from anemia. This process was quicker than taking iron alone. I think this combination of iron and gensing would benefit in ischemia as well. From doing this 02 levels increase gradually instead of all at once.

Well I guess that’s why they stack the formula in a product like NOS Black with ALA.

mravg,
I also don’t know the level of ischemia that can happen with PE. I am just throwing this out there as something we need to think about. If ischemia IS involved sometimes when we PE, it could affect gains for good or bad I don’t know. Or worse, you could damage the DNA of your penis and get cancer of the cock.

:rooster:

Mainly I guess if you use a product that increases NO, you need to also take antioxidants to protect yourself.