Wow, what a great detective story this is Ren. Keep us updated with this.
It’s a subject not well understood. The plumbing is much more the focus in medicine than the desire aspect.
What you mentioned about the fatigue reminded me a lot of chronic fatigue syndrome. CFS, written about since the turn of the last century and once called Benign myalgic encephomyelitis. It seems to be another rabbit hole.
It’s related to the symptoms seen in Fibromyalgia and both are thought to be somatoform disorders, or to put it bluntly ’ in your head ‘. I don’t believe this to be the case.
I do believe these both to be related dopamine disorders but I can’t be certain.
I have heard of people treating themselves and improving with NADH supplements.
Also, there is Pramipex*le, which is a dopaminergic for improving libido.
The levodopa in Mucun pruriens is mostly inactive without a COMT and or a MAO-B inhibitor present. Green tea helps in some respects. I suspect that in cultures where velvet bean was used there was something else present in the diet or in the preparation that boosted it’s effects and gave it it’s real strength.
Buproprion, also known as Wellb*trin or Zyb*n can stimulate the libido through norepinephrine reuptake inhibition. It may or may not have dopamine reuptake inhibition. It works very well in some and not at all in others.
Also there is Bremelanotide. This began as a peptide for the purpose of tanning research and was found to stimulate the sex drive through the melanocortin receptors.
I am not a pharmacist and don’t particularly like pharmaceuticals. I would rather go the natural route when possible but in the case of a serious disorder, sometimes the natural route will take much longer and won’t be as direct. Although I’m glad to hear you’ve had some improvement with DHEA, CoQ10, EFA’s etc.
The stuff I’ve mentioned is for the most part, tinkering with brain chemistry to get a desired result. Not a great idea, BUT if something vitally important isn’t working already then it becomes a trade off for something else potentially going wrong. You have to weigh the outcome yourself and review and test the safety of each.
Hopefully what happens is you kick start the system to work on it’s own again. After that you can live a normal life. Although it is important to get an answer for what was or is causing the original problem. When the body is fighting a disease of some kind, sometimes it ‘borrows’ from resources that are not vital to reserve the energy to keep fighting. Or the disease has caused a change in the function of the brain itself.
I wouldn’t think that any damage done is permanent because that’s just defeatest and highly unlikely. However something is/was likely at the very least suppressing your sex drive.
Keep getting bloodwork done. Someone may find something that someone else overlooked. The ferritin results sounded interesting.
Find a clinic to donate blood to monthly and see if anything improves immediately after you donate. See if there’s a libido spike. This would very much indicate hemochromatosis.
Not being in radiology, I can’t tell you how accurate the results of an ultrasound would be or not be as compared to an MRI.
Having said all that ( WHEW! ) if everything seems to be working, don’t tinker any more. The clomiphene won’t be necessary. (Did I read that you were releasing 1-2 times a day? That’s kind of more than half of anyone I’d say).
Sometimes supplements will take a while to start having an effect on the body. You may be giving it what it lacks and the body is doing some repair work.
I wouldn’t want to do TRT either.
Keep up the good fight and keep looking for answers Ren.
The detective story goes on…