Anti-lox And Pumping Success? Whats this Study Mean For Us

Abstract

This study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control, anti-LOX, VD (negative pressure value of -300 mmHg), and anti-LOX + VD. Penile length was measured by a modified VD method and verified on exposed length data. Intracavernous pressure (ICP) and maximum ICP/mean arterial pressure (MAP) ratio were recorded to assess erectile function. For corpus cavernosum, LOX activity and concentrations of pyridinoline, desmosine, hydroxyproline, and elastin were analyzed; transmission electron microscope and Hart’s elastin staining were performed to monitor microstructural changes. Anti-LOX and VD significantly lengthened the penis by 10.8% (3.75 mm) and 8.2% (2.48 mm) compared with the control group, respectively, while anti-LOX + VD achieved the longest penile size (40.58 ± 0.40 mm) which was 17.4% longer than the control group (34.58 ± 0.54 mm). After 1-week washout, no penile retraction was observed. Meanwhile, exposed penile length data confirmed that the penis in the anti-LOX + VD group was also significantly longer. Anti-LOX inhibited LOX activity to reduce pyridinoline level, which led the penile tunica albuginea remodeling. However, it had no effect on hydroxyproline, desmosine, and elastin levels. Moreover, anti-LOX had no impact on erectile function, which was determined by ICP and ICP/MAP ratio. These results suggest that anti-LOX elongates the penis by reducing pyridinoline, which induces tunica albuginea remodeling. This lengthening effect was more obvious when combined with a VD. All procedures had no impact on erectile function.

Keywords: anti-lysyl oxidase; crosslinking; penile lengthening; tunica albuginea remodeling; vacuum device.

This study was discussed in another thread you could locate easily (from around October this year I think). But, Kyrpa observed the below and more, with others amplifying. Bottom line seems to be good for a few well-hung mice in the study, but likely dangerous and even deadly for men.

From the discussion section of the referred study .
“Most importantly, anti-LOX with BAPN has been employed to induce thoracic aortic dissection in rodent models, and systemic effects after intragastric administration of BAPN could not be ruled out in the current study.”
Please, read more about the hazardous potential of the pills you are going to swallow like there is no tomorrow.
Also, make sure no one in your family, close or distant has not died on an aortic aneurysm. If you have the potential familial disease possibility, you can start betting how you are leaving too with this substance.

Remus EW, O’Donnell RE Jr, Rafferty K, Weiss D, Joseph G, et al. The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms. Am J Physiol Heart Circ Physiol 2012; 303: H1067–75.

Bruel A, Ortoft G, Oxlund H. Inhibition of cross-links in collagen is associated with reduced stiffness of the aorta in young rats. Atherosclerosis 1998; 140: 135–45.

Maki JM. Inactivation of the lysyl oxidase gene lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation 2002; 106: 2503–9

These are for a start