Do you really grow tolerance to Cialis / Viagra or is it a meme?

People say after some time Viagra / Sildenafil grows tolerance and you need ever larger doses and it stops working,

Is this true or a meme?

If it is true - in which scientific studies has it proven to be true?

If it is false - why people keep saying it is true?

Don’t men just age and get worse libidos in general due to testosterone reduction?

Your body adjusts to any drug.

Old age doesn’t mean loss of libido. What comes with aging is typically less activity and poor diet.

To any drug? Uhh…is this really true? Anyone else can confirm?

I have never grown a tolerance for either of them. I don’t think you are going to take them on a daily basis are you?

No, once or twice week max

I used Viagra and Cialis for many years but eventually they became less effective. I would say the cause (diabetes) intensified which caused the PDE5s to become less effective.

You won’t have any problem.

I’ve been taking 5mg daily for several years without any noticeable lessening of effectiveness.

So i seems like a meme and guys “lose effectivity” not because of drugs, but because of other age related factors.

Does it have to be severe diabetes?

It’s entirely possible that they become less effective.

The tissue receptors commonly up-regulate or down-regulate in response to drugs. For instance, pain receptors in the central nervous system up-regulate heavily in response to opiates; the effect is that opiate drugs don’t work at normal doses anymore and patients actually experience more pain than they should in the absence of the drug.

I’m not aware of study validating pde5 inhibitors becoming leas effective for ED, but it’s totally possible.

But most people, and even possibly all… don’t get desensitized if they have taken say 25 cialis 5mg, in a 9 yr period would you agree?

That’s a myth, I used to think the same thing.

Can’t get “used to Cialis”

I’ve been using drugs like Viagra, Cialis and Levitra for more than 8 years. It was prescribed by an urologist that teach me a lot about it.

Our bodies don’t get used to those drugs, but some other things may impact the dosage needed.

My ED is caused by porn addiction. When the addiction is controlled, low dosage is enough. If I’m masturbating 5 times a day, I can get to a place where any dosage isn’t enough. If I stop completely, I also can get to a place where I don’t need medication at all.

Many guys are using erection drugs for psychological ED. If anxiety (or any psychological problem) is getting worse, medication will start to fail.

In case of physical problems, such as Diabetes, you will find a dosage that works and it will work forever, IF your physical problem does not increase. If your physical problem increases, the dosage must increase as well.

Diabetes must be well controlled. Excessive sugar creates permanent injury to nerves and blood vessels. Diabetes ED is the result of nerve injury and/or destruction of capillary blood vessels of penis. If you are already suffering from Diabetes ED, you may need Viagra forever, but, if you control your sugar levels, you will be fine with Viagra or even daily Cialis (5mg). But, if you do not control it well, it’s possible that you need higher dosage of drugs till the point it stops working. It can be so severe that only penile implants to get erections back

Human body doesn’t get used to ED medication such as Viagra, Cialis and Levitra. But the things that are causing ED can get worse if not treated right, giving the impression that remedies are losing effect.