As a long time biker I can tell you that you do need to be careful, especially if you ride long distances (40 miles+), but there are a bunch of seats on the market now that are split down the center to be more accommodating to the equipment. One I rode for years is made by Specialized (see specialized.com, you can also look at performancebike.com and bikenashbar.com).
I agree with dansan about rising from the saddle often to allow circulation.
However, if you want to avoid the issue entirely, get a recumbent bike as I have. You sit on a comfy seat looking straight ahead instead of at the road. I’ll never go back to an upright bike. (see bacchettabikes.com).
But however you ride, it’s certainly worth it. I’ve ridden somewhere in the neighborhood of 20,000 miles since I started.
Just do it!