Caffeine A Potential Vasodilator?
Check this out guys, this was simply copy and pasted from a Facebook chat.. what do y’all think?
“Hi Kalin, coffee is only a vasoconstrictor in some aspects and only when you do not drink it regularly. “Caffeine is the most widely consumed stimulating substance in the world. It is found in coffee, tea, soft drinks, chocolate, and many medications. Caffeine is a xanthine with various effects and mechanisms of action in vascular tissue. In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation. In vascular smooth muscle cells, its effect is predominantly a competitive inhibition of phosphodiesterase, producing an accumulation of cAMP and vasodilation. In addition, it blocks the adenosine receptors present in the vascular tissue to produce vasoconstriction. In this paper, the main mechanisms of action of caffeine on the vascular tissue are described, in which it is shown that caffeine has some cardiovascular properties and effects which could be considered beneficial.”https://www.hindawi.com/journals/ijvm/2010/834060/ Also it is clear that coffee is beneficial for erectile dysfunction, which would seem pretty contradictory if it was indeed a vasoconstrictor don’t you think? “Caffeine intake reduced the odds of prevalent ED, especially an intake equivalent to approximately 2-3 daily cups of coffee (170-375 mg/day). This reduction was also observed among overweight/obese and hypertensive, but not among diabetic men. Yet, these associations are warranted to be investigated in prospective studies.”https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123547
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