It would be easy to turn look otherway but I can´t. I feel the need to shoot down bad science when ever I see one. DMSO and PE marriage is one of the issues.
The concentration needed for DMSO to weaken the collagen in normal healthy connectve tissue can´t be produced on living tissue.
“The amount of the other types of collagen, especially the insoluble fibrous collagen, was unchanged. As the firmness of collagen treated with DMSO decreased, we concluded that the intermolecular bonds had been changed. Therefore, we examined the tensile strength of rat-tail tendons before and after 24 hr treatment with DMSO in increasing concentrations in Ringer solution adjusted to a pH of 7.2 (FIGURE 1). It is not until a concentration of 95% DMSO is used that the tensile strength suddenly decreases. The circles show the expansion of the tendons by the pull of a weight of 100 gm, while the crowes indicate the expansion when 10 gm are applied. This sudden increase in extensibility is coupled with a shortening, a swelling, and an increase in translucency and elasticity. Collagen, being a linear polymer, can only react this way when its intermolecular bonds are broken.2 Such effects are also seen after application of other chemicals and higher temperature. As interesting as this question regarding the mode of action of DMSO may be, in living tissue, we can not obtain high enough concentrations of DMSO to alter the tensile strength of collagen in the fashion just outlined. In vivo, other modes of action must apply. Therefore, the question was of interest whether or not other physical changes of collagen exist that can be demonstrated after treatment of animals in vivo; or whether the decrease of collagen under the influence of DMSO, as seen in postirradiation subcutaneous fibrosis is caused, not by a direct effect on collagen, but, rather, by a change in the equilibrium between synthesis and degradation of collagen.”
So because there is no weakening of the collagen, could it possibly alter the metabolism of the normal healthy collagen tissue.
“The investigations using various test methods have shown that treatment of animals with DMSO causes alteration of the collagen fibres. After treatment, they swell in weak acids more rapidly by splitting of the intermolecular cross linkages of collagen fibres. Synthesis and catabolism of collagen decrease simultaneously during DMSO treatment. Therefore, there will be no significant change in the amount of insoluble collagen of skin. In contrast, as we could prove in our earlier investigations, DMSO excerts a significant effect on pathologically increased collagen in human postirradiation subcutaneous plaques,' but does not appear to change the equilibrium of the metabolism of collagen of normal tissue. Under the influence of DMSO, synthesis of mucopolysaccharides is decreased as well. Nevertheless, their amount in skin grows, following a more retarded breakdown. The effect of DMSO on the synthesis of collagen and mucopolysaccharides is comparable to the action of antiphlgistics. Total degradation of collagen is decreased during treatment with DMSO in humans. This is an effect similar to the one seen during application of cortisol.”
Apparently not.
https://nyaspub s.onlinelibrary … .1967.tb34932.x
START 18/13.15 cm Jul 24th 18 (7.09/5.18") NOW 22.5/15.2 cm Fer 12th 20 (8.86/5.98") GOAL 8.5"/ 6"
When connective tissue is stretched within therapeutic temperatures ranging 102 to 110 F (38.9- 43.3 C), the amount of structural weakening produced by a given amount of tissue elongation varies inversely with the temperature. This is apparently related to the progressive increase in the viscous flow properties of the collagenous tissue when it is heated. (Warren et al (1971,1976)