prions and PE

I read somewhere that the statistical risk of getting either Creutzfeldt-Jakob or Alzheimer’s tends to go up after a fever. However I did a quick google search for this but could not find any links. I did find a link describing how e.g. aspirin (which lowers a fever) can prevent the onset of Alzheimer’s:
From
How are NSAIDs related to Alzheimer's disease?
Researchers are still investigating the exact cause(s) of Alzheimer's disease. One avenue of research has shown that inflammation in the brain may play a role in the development of Alzheimer's. Because NSAIDs help decrease inflammation in the body, researchers believe that NSAIDs may aid in preventing or delaying the onset of Alzheimer's disease by decreasing inflammation in the brain.
(here the emphasis of the narrative is on inflammation however)

CJ and Alzheimer’s are related to proteins misfolding, and the chance of that happening goes up when the temperature is raised, as well as when pressure is added.

If we accept that temperature and pressure can unfold proteins, should we be worrying about the possibilities of CJ, Alzheimer’s, or another prion-like variant, through the long term use of PE? It may be that the temperature differences and pressure differences are not large enough to be significant. I hope so. But I wonder if years of almost daily exposure could make those factors significant.

There are only a couple posts on these forums on prions and mad cow- none related to the enhanced risk through PE.

I’m beginning to worry a bit more seriously about this. Heat unfolds proteins, pressure unfolds proteins. We apply both heat and pressure in doing PE. What could be the long term effects of repeatedly applying heat and pressure to a part of your body? On the other hand, many people take hot showers daily..

I would have to do a little more web searching and thinking about this to say anything more meaningful. But I thought I would throw this out there and see if anyone bites.

http://en.wikip … wiki/Alzheimers

http://en.wikip edia.org/wiki/C … eutzfeldt-Jakob

On the basis of mortality surveillance from 1979 to 1994, the annual incidence of CJD remained stable at approximately 1 case per million persons in the United States.

In the United States, CJD deaths among persons younger than 30 years of age are extremely rare (fewer than 5 deaths per billion per year).
Many Americans first learned about the disease when the famed choreographer George Balanchine died of it in 1983.

That has to be the best PE myth I’ve ever heard. Congratulations!

You are being unbelievably paranoid. I guess Swedes and Norwegiens that spend most of there lives (slight exageration) in saunas, should have a plague of Alzheimers going on.

Gprent, bam,
Are you sure? What grounds do you base your belief on- that Suedes spend their lives in saunas? (they dont)

I suppose in a way you are reiterating my comment, “We apply both heat and pressure in doing PE. What could be the long term effects of repeatedly applying heat and pressure to a part of your body? On the other hand, many people take hot showers daily..
so in that sense I agree with you.

To quote myself again, “It may be that the temperature differences and pressure differences are not large enough to be significant. I hope so. But I wonder if years of almost daily exposure could make those factors significant.”

Now and again we hear someone bring up the issue that “we have no idea about the long-term effects of PE” (5, 10 years or more), and basically we don’t.

The question is, could daily application of high temperature and pressure over the course of years increase the risk of forming amyloids or plaques in your penis? Moreover could such amyloids have more serious health consequences other than local scarring?

If you read the link that twat had provided, you would see that Alzheimers (and CJ) is an aggregation related disease caused by plaques which deposit in the brain. Prions induced plaques dont have to be formed in the brain but they can get stuck there. Beta amyloids and fibrils are both caused by misfolded protein that aggregated, so this distinction is academic in some sense. Do you know how often proteins unfold during their lifetime? 10’s to even 100’s of times.

I for one will continue to apply heat myself, and to jelq, etc. I hope that this is not something to worry about. On the other hand, its interesting that your comments are reminiscent of those comments Prusiner endured during the early days when he proposed Prions. I saw him give a lecture once where he mentioned this and the phases that a scientific theory (in his case prions) goes through. I can’t remember it verbatim (I might be missing a phase) but it went something like this,
1. The theory is wrong (e.g. a myth)
2. The theory is right, but its irrelevant/trivial
3. The theory is right, but I thought of it first.

In any event I hope it remains a myth. If you want to argue against it please put up some concrete data. In any event, bam, its a good myth, you can use it to keep people away from PE and preserve our secret society if you like. So thanks, congrats accepted. ;)

I can’t remember what we are talking about. It’s hot out here in Arizona and I have been under a lot of pressure lately.

Well, if you are young, worry about this in a few decades. Medical science will find some prevention/restoration/cure. If not, soon you won’t remember to be worried about this stuff.

Two friends of mine died from Kreufeld-Jacobs. One coaught it through a brain surgery in 1980, in a hospital in Boston. The other through birdfood (he was canary collector/breeder).

Prions are about the scariest thing I can think of. (Other than Hillary Clinton.)

:rolling:

True, I’m paranoid about them.

1 in 4 people will get cancer in their lifetime. And there is a barrage of other illnesses that could do you in before your time. Mad cow, crazy fish, nutty pigs or whatever the fuck you want to call it, is the most preposterous thing in the world to worry about. I was concerned about the problem myself when it first hit Britain in the 90s, but the sheer weight of logic eventually overrode my anxieties. The odds are just too low.

Nobody knows for certain where prions come from or how they work. They know they’re proteins. But not much else. Some have even postulated the prion came from outerspace(I don’t make this shit up). Some don’t even think the prion is responsible for triggering the aforementioned condition; they believe it might actually be a virus. It’s also very difficult to diagnose, and you’ll only know for sure once you’re dead and the doctors perform a post mortem on your brain.

It’s a statement of fear not fact, and it’s how things like this usually develop. Seriously, if you drive a car be afraid, but if you think PE is going to cause the unwrapping of proteins from connective tissue into darstardly hardcore prions…

DISCLAIMER: IF YOU PE AND GET A PRION BASED DISEASE DON’T BLAME ME, AS YOU’RE ALREADY DEAD.

That should keep the new member rate down for a bit.

I keep seeing this thread title and thinking “huh, prisons and PE. That’s an interesting concept.”

I wonder if it would be a good rehabiliation method. Get a bunch of convicts on a dick enlargement program. See if it results in lower recidivism.

However, there’s probably about as much a chance of that as prescribing Viagra to sex offenders.

Okay, so…now back to your regularly scheduled scary-ass thread.

Yeah, I thought it said “prisons and PE” too. But all I could think of was an even BIGGER cell-mate doing me up the ass!! Might be even worse than prions.

Actually they do, there was in the news in the past twn days to 2 weeks.