Originally Posted by carrotsrorange
London, you can confidently walk on the street knowing that you are larger than most men you see including those on this forum. Although I am all for PE research, (search for my thread called ‘an academic’s perspective’) the reasons you are doing it for are baseless and the experimental methodology you described not sensible. Is he going to give his dog and erection? If you want to fund a study involving PE, figure out a way to design an experiment that figures out why people have such diverse results with PE.(excluding a bias of bad technique).
This thread is simply crazy.
The researcher would give the dog an erection by injecting it with pge-1 and measure size changes using callipers. I assumed that the anatomy of a dog’s penis was pretty much the same as that of a human. I have just discovered that dogs have bones in their penises. That would probably make the experiment inapplicable to humans. I never claimed to be the brightest bulb in the tanning bed, but at least I am open-minded and willing to learn.
The theory behind this is not baseless. I have just sent an email to a penis enlargement clinic in India asking for advice (I paid $300). The email that I sent sums up what I think about the wonderful world of CPE:
………………………………………….. …………
Dear Sir,
I am a student from the UK. I am extremely insecure about the size of my penis. This is more of a psychological condition than a physical one. My penis size is above average.
A Canadian doctor named Kenneth Adams took out a patent on a new form of penis enlargement.[1] He began treating clients with this technique, which was based principally on megadoses of erectile dysfunction meds such as Alprostadil. He continues to offer this service, but is taking on no new clients. There is also anecdotal evidence to be found on the internet of people using megadoses of filtered research grade PGE-1 and achieving substantial enlargement. The aim of this treatment is to simulate high-flow priapism: a condition that is very occasionally associated with massive enlargement without loss of potency.[2] There is evidence that megadoses of Papaverine can induce smooth muscle hypertrophy in primates.[3] I contacted a researcher who performed one of these studies and asked him if an increase in penis size took place. To my surprise, the researcher, who is a professor of urology, informed me that a visible enlargement took place. Do you think that megadoses of ED drugs could induce enlargement? What is your professional opinion on the safety and efficacy of this form of treatment? Have you tried this treatment at your clinic?
An American doctor named Charles Runels offers a service called the ‘priapus shot’.[4] This involves the injection of platelet-rich plasma (PRP). The doctor charges $1,900 for a single shot. I am reliably informed that this treatment is totally ineffective. The concentration of VEGF and other important growth factors in PRP is roughly three times higher than in normal blood. VEGF has been shown to radically increase smooth muscle content in animals.[5] A single shot can increase smooth muscle content by around 10 percent. (The results are not always statistically significant because of the high standard deviations.) VEGF has been touted as a potential cure for various forms of ED, but human trials have not yet been attempted. The penis is roughly 50 percent smooth muscle. Is it reasonable to presume that a 20 percent rise in smooth muscle content would result in a 10 percent rise in penile volume? Would it be theoretically viable to inject VEGF at three times blood concentration over the course of several months in the hope of enlargement?
Regards,
xxx
[1] http://patft.us pto.gov/netacgi … 22&s2=adams&OS=
[2] An unusual case of priapism. - PMC
[3] Chronic papaverine treatment: the effect of repeated injections on the simian erectile response and penile tissue - PubMed
[4] Priapus Shot (R) | Grow larger penis with Platelet Rich Fibrin Matrix
[5] Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats - PubMed
