I will post results here when my order for Stendra/Spedra arrives from PDD.
It’s strange how much variation there is in men’s reactions to these products. In researching avanafil I ran across a forum of some kind where men discussed their experience with the then just-released Stendra. A lot of them said it worked really well for them, and a few said it worked ok but other drugs worked better. But a significant number said it had abolutely no effect at all (but other drugs worked well for them). I’ve come to the conclusion that the only way to find out which one works best for an individual is to try all of them and see. My own experience so far is that Viagra and Levitra usually, but not always, work reasonably well for me, but I feel awful all day the next day. Cialis doesn’t make me feel bad, but doesn’t work very well either. Stendra supposedly has fewer side effects than V or L, so I think it’s worth a try. But really I’m trying it because I haven’t tried it before, and there’s at least a chance the luck of the draw might end up with it working really well for me with no sides. No expectations though. There are men who get very little or no benefit from any of these drugs.
However, there is a complicating factor. According to the avanafil prescribing information, the two drugs I take for blood pressure are “moderate 3A4 inhibitors”, and as a result I’m supposed to limit the dose of avanafil to 50mg once a day, as opposed to a standard dose of 100mg, or a maximum dose of 200mg. Originally that warning said 100mg every 48 hours, but they’re revised it recently. Anyway, I doubt 50mg is gonna do it, but 100mg might, and every other day wouldn’t be so bad. :-) Avanafil is metabolized (removed from the body) by CYP 3A4, so the effect of the other drugs is to increase the maximum serum level, the AUC (area under the curve), and the half-life of avanafil, and thereby increase the risk of side effects. Grapefruit juice does the same thing. But of course the other effect is to increase avanafil’s effectiveness. So we’ll see. Maybe 50mg will work after all. And that would bring the price down to a little over $3 per dose for the brand name, which wouldn’t be bad at all.
WhiteNoise, where did you buy your Sunrise Avana?