Originally Posted by Kirin
Intereting. Where is stagestop when you need him?
Just like the cops, I was at the dougnut shop enjoying life.
This is kind of an interesting item, but I think that it is premature at the moment. As I look at the ad, it seems that what they are selling is simply a carrier and not a compounded pharmaceutical. The reason for saying this is that they mention that the mix must be prepared by a compounding pharmacy. The compounding pharmacy already has all of the ingredients of a tri mix. The ad mentions that PGE-1 is included in their formulation (?) or at least it could be a component in the transdermal mix.
The good points that I see here are:
1. No injections, and that is a big plus, as there are tons of men that fear injections.
2. A trans dermal would have to penetrate the tunica to get into the CC where it would react. This would seem to be helpful in allowing for remodeling of the tunica much more easily than having to go through the CC and out to the tunica as would be the case for injected items.
The negatives seem to be challenging though. The first item that would be a challenge would be in regulating the dosage. In an injection, the amount of components in the mix is set by the physician. The dosage is accurately measured in the syringe, and all of it is injected into the CC. With experience, the person injecting can determine how long he wants to be erect through experience.
In the case of a transdermal, most of the active ingredients in transdermals to not make it through the skin. In things like adrenal hormones, where the need for precision on the dosage is not all that critical, this is not an issue. As an example, with a testosterone transdermal, some people get 20 mg twice a day in their compound. However, only about 10% or so makes it through the skin, yielding about 4 mg a day.
With PGE-1 the dosage starts at 1 MCG, or 1/4000 of the dosage listed above for testosterone. PGE-1 is VERY powerful, and is given in VERY SMALL Dosages. With the variability of transdermal medications making it through the skin, this has the potential for a lot of trouble (read this as priapism big time).
Comparing this to what Caverject offers may shed some light on the dosage issue. Caveject, which is pure PGE-1 comes in a “kit” which contains a syringe that has a mixing chamber in the syringe. The kits come in 20 and 40 mcg strength. Both kits are adjustable in 5 mcg points by use of the dosing restrictions in the barrel of the syringe. The barrel is rotated until the correct dosage comes up. Depressing the top of the syringe caused the liquid to be ejected. The plunger can only go down so far, as set by the dosing gauge, which then stops the syringe from allowing more solution to be ejected.
The point that is important here is that for men with ED, dosing starts with 5 mcg. For an 18 year old male that does not have ED, ONE mcg may be sufficient to give him quite a long lasting erection.
The next point would be the question of penetration into the CC. PGE-1 that remains in the skin will not do anything. I don’t know what PGE-1 in the tunica would do. I am guessing that it would not do anything, but then as I only have one penis, I think a little reassurance would be in order here. For the PGE-1 to give a person an erection, it has to make it into the CC. With two different layers of the body to get through, titrating a dosage would seem to be a problem.
Next, compounding pharmacies already have base transdermal cremes. If the pharmacy wanted to make up a transdermal mix with PGE-1 in it, they can do that now. Obviously, they don’t do it if for no other reason than no physician is prescribing it. Which brings me to my last comment:
The documentation on the physicians side is about as light as I have ever seen. There is no research to indicate that this method would be appropriate for anyone. Comparing this to the voluminous research on the individual components in the standard ED injectable items, it shows that they manufacturer has done no homework at all.
My conclusion is that I would be hesitant about using this product based upon their current claims, and lack of testing of the product.