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NKISK pentapeptide, the HOLY GRAIL of PE?

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Originally Posted by Kyrpa

But the question is still relevant. How is the excessive NKISK eliminated. By which mechanism?

When it gets to in to bloodstream, and involved with your collagenous aortic tissues and valves, what would happen then?

I am not sure by what mechanism. I am no scientist. Just a guy with an interest in finding something more efficient. But from what I’ve read, and understand from other things, like let’s say you drink too much electrolytes, the body will use what it needs and discard the rest through the kidneys.

So I imagine it discards stuff through the kidneys into your urine, or your fecal matter exit. That is the most common ways.

For some drug like Aminopropionitrile, also known as β-aminopropionitrile (BAPN), which also show some weakening of the collagen, and only need to apply topically to have an effect, there is trace found in the urine as it is absorbed by the skin and later excess discarded through urine. This Aminopropionitrile I think IIRC is quite toxic I think I can’t remember why it would not be a good thing to rub on your dick, but it showed some interesting results with creep.

For the last question, we can’t know, but having a panel on the hemolitic and cytotoxic activity would be somewhat comforting. That way we can know if the NKISK kills the red blood cells, and if the death follows a normal or accelerated death via apoptosis, or if the death is more unnatural like necrosis caused by external toxins.

The experiment they did on the rats there was no side effects for the rats over 4 weeks. But who knows maybe 6 months down the line what can happen.

For the collagen in other parts of your body, I don’t think it would be that affected as for 8.8mm they use 1/10th of usual 1ml solution, with the highest concentration tested of NKISK of 200mM and the effect on length was not significant. I guess because the volume was only 10% of usual 1ml. So if it has no effect on the target, probably not that significant elsewhere.


Genesis 2006 = 5.8" x 4.7" /// Round 3 2019: Hanging again = 7.99" x 5.5" /// ST Goal 2019 = 8" x 6" /// End Game 2020 = 9" x 6.5"

What does anyone think of just trying this once for 4 weeks? Would anyone do it if money wasn’t the issue?


Genesis 2006 = 5.8" x 4.7" /// Round 3 2019: Hanging again = 7.99" x 5.5" /// ST Goal 2019 = 8" x 6" /// End Game 2020 = 9" x 6.5"

Nope!

Wow it’s as if someone proposed everyone sting their dongs with hornets or something in here 😂. I don’t really see what the big deal is. Seems interesting at least to discuss. Thank you Manko for bringing it to the forum’s attention. I’m focused on other things right now but will be interested in looking at this some time in the future. I recall that many years ago there was wide spread interest in relaxin but the cost was prohibitive so no one ever got to use it.

Originally Posted by sentii
Wow it’s as if someone proposed everyone sting their dongs with hornets or something in here 😂. I don’t really see what the big deal is. Seems interesting at least to discuss. Thank you Manko for bringing it to the forum’s attention. I’m focused on other things right now but will be interested in looking at this some time in the future. I recall that many years ago there was wide spread interest in relaxin but the cost was prohibitive so no one ever got to use it.

Well there are reasons for the reaction. Anyone posting anything claiming it to be a holygrail of PE should prepare to have shitload of loaded shit on them.

Secondly comes the unknowns. I can pick up few of them.

- we don´t know the half life of the peptide
- pentapeptides easily passing the blood brain barrier

That said we don´t want to take the risk peptide get carried in the bloodstream not knowing how long it stays active and what are the consequences getting in your brains. Another aspect which worries me the most is the concerns of effects on the collagenous valves and aortic tissues of heart. Are we risking to have aortic aneurysms , exponentially enlargening left venticular chambers etc. Keeping in mind rats in the study elongated their patella tendons by swimming alone. How about pumping the heart then.

As we don´t like to have peptide loaded with serious unknowns in the plasma we would need to pick the injection spots very carefully.
CC´s are out of the question because the risk of getting the substance in to bloodstream with a strong concentration.
Next to evaluate is the tunica. If we were trying to inject it to between thin layers in multiple spots along the shaft I think we are doomed already.

We would need thick collagenous tendon like formation or another more meatier spot to place the injection.
There are four of them both ventral and dorsal triangular formation of the septum and both ventral thickenings of the tunica place.
Dorsal formation being too risky because of the multiple veins and arteries laying in the top of it.
Ventral thickenings being the safest option but the effect being not so effective lengthwise.

What I could think of a more of a challenging place to inject and effective place also both length and girth wise is the triangular formation of the septum at the ventral junction of the CC´s .
Injecting through CC from the ventral site in the angle avoiding the CS aiming the tip of needle in the middle of the shaft.
There we can possibly find carefully palpating injection sites along the shaft avoiding both venous and nervous obstacles.

This is not even commercially available bulk substance at the moment I recall , if we like to purchase NKISK it would be specially synthesized for us by the laboratory.
No studies carried about the safety at all or that we can´t find them. Very risky business all in all and understandably rejected with the information available.
I would consider myself taken a lot of serious health risks during my former bodybuilding life and finding this to be at the highest level.

Really interesting though.

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START 18/13.15 cm Jul 24th 18 (7.09/5.18") NOW 22.5/15.2 cm Fer 12th 20 (8.86/5.98") GOAL 8.5"/ 6"

When connective tissue is stretched within therapeutic temperatures ranging 102 to 110 F (38.9- 43.3 C), the amount of structural weakening produced by a given amount of tissue elongation varies inversely with the temperature. This is apparently related to the progressive increase in the viscous flow properties of the collagenous tissue when it is heated. (Warren et al (1971,1976)

I got $10.


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