Originally Posted by kingme
Hmmm. I am not convinced by anything you said so far, I’m sorry.
No need to apologize.
Originally Posted by kingme
First of all, histamine is present in almost all cells of the body and is released only when needed. Elevation of histamine in the blood is only a temporary condition, triggered among others by allergies, parasites.
Histamine is in every cell, it doesn’t mean it is at an optimal or normal level. Your elevation example is only for NORMAL people who have the right levels.
Originally Posted by kingme
5HPT is a precursor of serotonin but it can be found in a lot of normal food people eat, in the form of tryptophane. Severe lack of triptophane is very very rare and is associated with malnutrition. Increasing the uptake will have limited effect.
People eat so healthy now? You are what you eat. I agree diet plays a role in mood, but how many people eat the right foods, especially in an Industrialized Western society? Is this going turn into a vitamin debate?
Mood-Food Relationships - effects, nutrition, body, diet, absorption, carbohydrate, protein, fat, eating
Why Am I Craving Sweets?: The Link Between Sugar and Depression
Originally Posted by kingme
SSRI do not work by emulating serotonin. They prevent it from being reused in the synapses of the nervous system.
I should have explained it better. I attempted to be more generalized to combat any translation issues. So that is my fault.
Drugs emulate or rework a common substance into Patentable & protected product that re-engineers and results in a treatment. Supplements can be sold by anyone really. An SSRI just removes the fuel return line to the tank, so more floats around, if we look at it from an automobile analogy. Tryptophan, SAM-e, and 5htp cause a blanket rise in the serotonin level. Lots of Drugs attempt to work on specific subtypes of neurotransmitters these days. An SSRI will not make a single ounce of extra serotonin anywhere. It tricks the backend to make it feel like it has. SSRIs are just a greasy monkey trick pharamcologically. So like you said, it doesn’t get sucked back up and can float free.
Selective serotonin reuptake inhibitor - Wikipedia
Escitalopram - Wikipedia
Tianeptine - Wikipedia is a special drug http://en.wikip … a.org/wiki/SSRE
Serotonin–norepinephrine reuptake inhibitor - Wikipedia
5-Hydroxytryptophan - Wikipedia Pretty much the highest end product OTC, that has less steps to go through to reach Serotonin.
S-Adenosyl methionine - Wikipedia
Serotonin - Wikipedia
Tryptophan - Wikipedia is the lowest on the link to finally be cracked down like oil into the end product of Serotonin.
Originally Posted by kingme
I would advise anyone to be cautious with exceeding the dosage of vitamin B3 (niacin) because in high dosage it will have secondary effects and that does not mean you have any kind of high histamine levels. The only way to know how high your histamine blood level is is by a proper blood test at a proper lab, and I doubt anyone does it frequently.
250mgs of Niacin Deadly? 50mg if you are extreme in high histamine? That is all you need to do the testing at home. I guess it must be a weapon of mass destruction? I guess the armored cavalry is going surround every drug store in the USA. They are like on every corner now, so we need lots of tanks and men.
"Some people can find it confusing to figure out which one they are. A simple test you may try is to buy some niacin 50 mg. (nicotinic acid niacin which causes the flushing). If you flush from only 50 mg. of niacin then you are a high histamine type. You can try some aspirin or some amylase or calcium to counter the flushing which you may find uncomfortable. (You will probably never use that 50 mg. nicotinic acid supplement again since you sound like a histadelic, so you might consider the blood test option.)"
So I agree, that a blood test would be the best option, but you have to have a doctor write you a script to be tested in the majority of cases. Most General practitioners have a limited scope of knowledge, specialists in theory should be better, but not always.
Originally Posted by kingme
If you want to advise people to try herbal or homeopathic treatments, please specify so. Don’t lead people into thinking it is common allopathic medicine.
I explained that it wasn’t a mainstream application. Did you miss that a few posts above and in every thread I discussed about it? Did you bother to read the orthomolecular links, which explains that in the criticism? Thanks for taking the time there, my friend, I appreciate it.
Mainstream Medical and psychiatric don’t care for any type of Orthomolecular explanations. Even funnier is histamine is a fringe element in most orthomolecular circles as well.
Technically, my friend, we are on a fringe site after all. Are you going to ask for scientific proof before you start yanking your crank here too?