Clomiphene (Clomid) For Low Testosterone Levels

BJU Int. 2012 Nov;110(10):1524-8. doi: 10.1111/j.1464-410X.2012.10968.x. Epub 2012 Mar 28.
Clomiphene citrate is safe and effective for long-term management of hypogonadism.
Moskovic DJ1, Katz DJ, Akhavan A, Park K, Mulhall JP.
Author information
Abstract
OBJECTIVE:
To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG).
PATIENTS AND METHODS:
Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) results were collected for all patients. Demographic, comorbidity, treatment and Androgen Deficiency in Aging Men (ADAM) score data were also recorded. Comparison was made between baseline and post-treatment variables, and multivariable analysis was conducted to define predictors of successful response to CC. The main outcome measures were predictors of response and long-term results with long-term CC therapy in hypogonadal patients.
RESULTS:
The 46 patients (mean age 44 years) had baseline serum testosterone (T) levels of 228 ng/dL. Follow-up T levels were 612 ng/dL at 1 year, 562 ng/dL at 2 years, and 582 ng/dL at 3 years (P < 0.001). Mean femoral neck and lumbar spine BD scores improved significantly. ADAM scores (and responses) fell from a baseline of 7 to a nadir of 3 after 1 year. No adverse events were reported by any patients.
CONCLUSIONS:
Clomiphene citrate is an effective long-term therapy for HG in appropriate patients. The drug raises T levels substantially in addition to improving other manifestations of HG such as osteopenia/osteoporosis and ADAM symptoms.
© 2012 BJU INTERNATIONAL.

Clomiphene citrate is safe and effective for long-term management of hypogonadism - PubMed

J Urol. 2014 Sep;192(3):875-9. doi: 10.1016/j.juro.2014.03.089. Epub 2014 Mar 21.
Testosterone supplementation versus clomiphene citrate for hypogonadism: an age matched comparison of satisfaction and efficacy.
Ramasamy R1, Scovell JM1, Kovac JR1, Lipshultz LI2.
Author information
Abstract
PURPOSE:
We compared satisfaction and treatment efficacy in men with symptomatic hypogonadism who received clomiphene citrate or testosterone supplementation therapy.
MATERIALS AND METHODS:
Men treated with clomiphene citrate, or testosterone injections or gels for symptomatic hypogonadism (total testosterone less than 300 ng/dl) reported satisfaction with the current treatment regimen using the qADAM questionnaire.
RESULTS:
A total of 93 men on testosterone injections (31) or gels (31), or clomiphene citrate (31) were age matched from a retrospective cohort of 1,150 on testosterone supplementation therapy. We compared men who received testosterone supplementation therapy to 31 not on such therapy, who served as controls. Median serum testosterone increased from pretreatment levels in all men regardless of therapy with clomiphene citrate, and testosterone injections and gels (from 247 to 504, 224 to 1,104 and 230 to 412 ng/dl, respectively, p <0.05). Final median serum total testosterone in men on clomiphene citrate (504 ng/dl) was lower than in men receiving testosterone injections (1,014 ng/dl, p <0.01) but similar to that in men on testosterone gels (412 ng/dl, p = 0.31). Despite different serum testosterone levels men on all 3 therapies reported similar satisfaction on qADAM, including a score of 35 for clomiphene citrate, 39 for testosterone injections, 36 for testosterone gels and 34 for control treatment (p >0.05). Men receiving testosterone injections reported greater libido than men on clomiphene citrate (4 vs 3, p = 0.04) or testosterone gels (4 vs 3, p = 0.04), or controls (4 vs 3, p <0.01).

CONCLUSIONS:
Testosterone supplementation regimens and clomiphene citrate are efficacious for improving serum total testosterone. No difference in overall hypogonadal symptoms was noted among men on any testosterone supplementation therapy. Despite lower serum total testosterone, men on clomiphene citrate and testosterone gels reported satisfaction similar to that of men treated with testosterone injections.

Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Testosterone supplementation versus clomiphene citrate for hypogonadism: an age matched comparison of satisfaction and efficacy - PubMed

Very good research. Thanks marinera. I have thought about asking my Doctor about this so i could get off the injections and maybe my testicles will reboot.

I did the Clomid and it does definitely boost testosterone production if you’re truly hypogonad. It boosted my test levels and then I had to take an anti-estrogen because my estrogen levels were a little elevated. I’d still be on it except it didn’t help at all with the primary symptoms I had, which were constant lethargy and some mild ED.

Instead I dropped 40 lbs of body fat and feel so much better and have been off the Clomid for almost 2 years now. The funny thing is that I just had my testosterone levels checked again and I’m still low even after dropping all the fat. But, I still feel a ton better.

I want to drop another 20 lbs (that’ll put me at about 10% body fat) and then get my levels checked again. If they’re still low, then I might look into the Clomid route again to get my test levels back where they need to be for overall health including heart health and bone density.

The problem with Clomid is that, many guys report, can have crazy effects on the mood.

I’d have to say that Clomid itself isn’t the problem with crazy moods. Generally, the mood swings are seen in guys that are using heavy doses of anabolic steroids and then using Clomid to kickstart their system to create their own testosterone when coming off a cycle. Then, it’s the crazy swings in testosterone levels that are causing the mood issues.

It’s my opinion that if you’re using Clomid properly and for the right reasons, you shouldn’t see crazy swings. I know I never experienced any sort of mood swings, and I was not trying to get a super high testosterone level and I wasn’t trying to combat any post-cycle drop like steroid abusers are.

Again, if you are truly hypogonadic, I believe that Clomid might be a good option. I was under supervision of a Urologist who specialized in male fertility and was very well versed in Clomid therapy for testosterone and fertility issues in men. I didn’t have any fertility issues, but wanted to maintain my fertility while also increasing my testosterone levels. That’s one of the benefits of Clomid therapy. Usual TRT using testosterone derivatives will cause a decrease in fertility. Clomid does not have this effect.

Doesn’t happens only to bodybuilders, Midtigh

Clomid makes me crazy! — The Bump
Clomid is making me crazy!!! | BabyCenter

“Mood swings is perhaps the most notorious Clomid side effect.”

Taking it before going to sleep greatly lower that risk, anecdotically.

Could anybody recommend a cheap and effective brand?

The generic should work fine Buulet. But are you sure you need clomiphene? No drug is free of side effects.

I freaked out 1st time I used it.

I just wanted to try something different to give me an edge in the gym. I have already tweaked my diet and routine here and there, experimenting with this and that, but it seems I have hit a plateau.

Change something in your training. Go to higher or lower reps for a while, change some exercises. Taking a drug to perform better in the Gym is worth only if you make money from sport, IMO.

Could you extend please?

I altered my routine and diet. I am going to play college football soon and am currently training for it.

I agree with Marinera. You can use some pre-workout. It done an incredible focus and don’t have side effects.

There seems to be some other health side effects from taking clomid. I read this article last night and thought it might be worth while posting.