Urethral/topical tadalafil (liquid/powder cialis) application?

greetings.
if anyone knows of the tadalafil(liquid cialis / powdered cialis) molecule, given it’s size, readily absorbing from a topical application inside the urethra, using no carrier, is:
1. possible
2. effective
3. if localized absorption is strong, how much to reduce dose by?
4. any side effects of this application?

I would prefer to administer either the Liquid Tadalafil or the powderd tadalafil by this direct urethral/topical method, but if this will not suffice, perhaps a transderaml method would be best:

Apparently, several known transdermal carriers exist:

Transdermal Delivery of Tadalafil. I. Effect of Vehicles on Skin Permeation; Drug Development and Industrial Pharmacy - 35(3):Pages 329-336 - Informa Healthcare

apparently, propolene glycol is a good method, but i do not have a prescription to this site, and would like to see a full text version for details.
If anyone can help with this, please let me know. thanks.

And also of course DMSo can transport it transdermally, but i wish to avoid DMSo entirely, as I am very cautious of any bad neuro side effects.
If anyone is familiar with other, safer/gentler carriers for a transdermal application, please let everyone know :)

1. To keep the effects as localized as possible.
in addition to being a PDE5 blocker, tadalafil is a quasi-PDE11 blocker, and while there are no known side effects for this, PDE11 is involved in the kidneys, skeletal muscle, and other organs.
i’d rather keep my research as localized as possible.

Other unintended benefits might possibly be:
2. Faster action by the tadalafil on the glans and corpus (5 minutes instead of 45min)
3. Lower mg dose needed to achieve what 10-15mg can achieve thru an oral dose ($ savings)

I currently am researching the liquid Tadalafil from ChemOne. After some time with that, I am considering ordering the powdered Tadalafil for researching this urethral/topical application style. After having found ChemOne’s Liquid tadalafil to have good quality, will I be satisfied with the Powdered tadalafil from Elitenet pharm? Or does someone have a better source for the purest powdered tadalafil ?

I have found something which is interesting regarding urethral/transdermal tadalafil application:

When I took Tadalafil orally, I noticed I got mild heartburn. Apparenty this is a symptom that occurs in some users, and I looked into why this is, and found some user-claims that Tadalafil caused esophageal erosion, so that immediately caused me to assume that it has a corrosive effect on mucous membranes, making the urethral application a big no-no, as I’ve already had a UTI, and don’t want the burning urine again.

But after further research, the user’s assumption was incorrect, the reason Tadalafil causes heartburn is not due to it having a corrosive force on the esophogus at all, it is due to it relaxing the lower esophogeal sphincter, which is the thing that opens when food enters the stomach, then closes as to not allow any food or stomach acid to come back up.

So, taking a urethral dose, will likely make the effects less systemic, and tending to be more localized, which would likely significantly lessen the heartburn inducing esophogeal-sphincter-relaxation.

Fascinating concept I’ve been curious about for the longest time. I too would be interested if anyone finds an effective delivery method.

I tried doing these urethral appllications several times, with raw tadalafil powder, and I’m fairly certain it doesn’t have the same effectiveness when administered thru this pathway, as it does orally. I am exited to find another less-systemic pathway of administration, due to tadalafil’s relaxation of the esophageal sphincter, which can cause slight heartburn (stomach acid gets into the esophagus easier when on tadalafil) Perhaps I will next try DMSO or another topical penetration enhancer.