Dedicated PE gel

From their website enlargel just seems to be a gel with 12 herb extracts ( gingo, horny goat weed, macca etc.). At $120 for 6 fl oz. I think it would be damn sight cheaper to crush a few herbal tablets, make a paste and slap that on your dick.

There’s quite a debate about Enlargel on another thread. Suffice to say it’s not the kind of thing I had in mind.

Pardon an ignoramus, Shiver, but some of what you’re talking about does seem scary to me. Any drug powerful enough to cause real changes is something I, personally, would steer of. Imagine if some drugs made your dick shrivel up and die! I know it might be a small advance in finding something that did work but it would be a f***ing disaster for the guy who found out!

I agree entirely, which is why you don’t have me reporting whether it worked or not :D

Then again, generations previous must have walked around the forest eating sniffing and smoking everything in order to learn what doesn’t work!

It’s certainly an interesting notion, this “PE Gel” thing, I suspect it may indeed be the latest product boom on the horizon. Hell, it’s actually been out there for a while, I seem to remember something at the old PEforums in an add.

Really, if you dig the supps and feel they are actually working to any degree, probably best to eat them! Dick skin is not exactly the best place to get transdermal absorption. Back and shoulder blades, legs, and chest are actually pretty tough in the arena of transdermal (OTC) when it comes to effectiveness. Then you’ve got the potential irritation issue to deal with, that could get rather nasty.
Finally and most surprisingly not mentioned is the contradiction in purpose…it’s kinda hard to envision a transdermal that would make a decent lube or vice versa. It either soaks in effectively or it doesn’t. If it does, it’s a sucky lube! Can’t comment on the potential for transport in an oily matrix, but I’d bet anything it’s considerably less than optimal. A quandary, if you will.

I don’t mean to be so negative on this issue, it’s just that when one looks at it rather simply and from a practical standpoint, one needn’t rummage through a great deal of science or anecdote on the matter. A “transdermal lube” is really the marriage of two opposites in a way, makes me think they can cancel each other out pretty easily.

Astute observation! Also true that we haven’t stopped yet:) Not just PE stuff and wild carrots either, every year someone ends up in the ER out here in the midwest due to ingesting that funky version of Datura that grows roadside…then there’s the “wrong mushroom” incident every spring, too. Brave experimentalists we are!

Although a gel has its limitations (absorbtion limits, cost inefficiency, molecular weight limits, systemic absorbtion etc), it shouldn’t be ruled out, as many or even most supps have different properties depending on what part of the body we’re talking about. Oral route has its limitations also, and stomach acids often render medication/supps inactive. If it were any different then syringes would be very scarce.

The only reason I opened the discussion with the gel proposal is if I’d said “penis injections” it would make most peoples brown star wink. I’d like not to rule out any delivery methods at all, at least not before there is a viable proposal on the table. Judging from the limited response so far though, it doesn’t look like anythings going to happen.

Am I right in thinking that any effective drug has to enter the blood stream? So rubbing a potion on your dick is never going to be an effective way of getting the stuff (whatever it is) into your bloodstream? So even if an effective drug for making your dick grow was found, applying it topically would not make sense. Again I don’t understand the science but am interested in the possibilities.

Well, the penis CAN absorb topical gels, at least in (actual) clinical settings with certain drugs and substances. Some vaginal estrogen creams used in HRT have been reportedly absorbed by the penis in measurable levels. IIRC, the E used was Estradiol (sp?) and I think that’s one powerful humdinger of an estrogen. Verapamil Gel has been tested in Peyronies treatment and it does get into the bloodstream enough to be measured, no penetration or traces found in the tunica samples taken, however. Don’t ask me why they tried that, I don’t have more than very scant understanding of Verapamil uses in medicine.

Jist of it is, the dick CAN absorb stuff which enters the bloodstream. The actual utility of application there is subject to question, doesn’t seem to be a local effect pertaining to PE. Do remember, the above reports of topical gels and the dick are actual medical studies on typical folk, not PEers. I’ll go out on a limb here and say that transdermal potential for active PEers is somewhat different, even effective prescription gels with optimal drug/hormone formulations would likely be less effective on the PEed penis skin. It’s tough, it’s sometimes swollen, not a good skin area for transdermal absorption. Look at the longevity of some cases of PE induced discoloration, I doubt that a similar bruise on a non PEer would take so long to disappear…we’re different there.

Anyone ever try Androgel? It’s a prescription T therapy gel. Just curious.

The tunica is a tough SOB to penetrate but there are ways off affecting tissue permiability that could be explored. It might need a multi faceted approach (topical, oral and intraurethral concurrently), I don’t know. The big claim from PD Labs and their verapamil gel was their delivery method which they won’t disclose.

This issue of topical getting into the bloodstream is probably more of an issue of whether the stuff does anything undesirable in other parts of the body. For example, an effective collagenase would probably damage the penile and other skin at the same time. A successful regimen would have to sucessfully target, or at least tag something unique about the desired tissue only.

I never tried brand name androgel, but I did try a compunded testosterone gel with a slightly more agressive carrier. I also made my own with straight testosterone in a ‘local’ gel. It didn’t do anything for me. I’ve heard great stories about it from a select few though, which leads me to believe that their condition left them predisposed to the benefits. Out of 100 men I’d bet on there being at most 1 that would see a positive effect. I couldn’t begin to explain why that would be.

More than likely. You can do a search on it here and probably get some threads or posts on it, I’m not certain though. The transdermal ideas have been thrown around in the past, but for some reason there isn’t much follow up on the results of the idea. Whether it be arnica, aminos, transdermal vehicles, whatever…folks don’t seem to get the results they were looking for or perhaps they just didn’t give it enough time.

It’s actually rather interesting to see this sort of thing over time, some of what is in this thread will likely serve as advertising fodder for a product “review” site. I almost hesitated to mention discoloration issues and toughness of the penile skin mainly for the reason that it will, sooner or later, be used as an advertised effect on some PE product. Haven’t seen it yet in an add, but one can be sure…

Shiver, I think the “1 in 100” seeing a positive result may simply be just a case of deficiency in some individuals. Also, it appears the effect tends to wear off after while with alot of these rare cases, perhaps the body normalizes and rebalances afterwhile?

I’m convinced you’re right there. Further, Dr Pezzi documented the use of Finasteride and DHT (3months F, followed by 1 month DHT I think). He claimed some great gains in that one month (3/4”), but said most but not all of it just as rapidly diminished. He believes this is due to andro-receptor sensitivity. If you think about it, it’s not much different to cycling regular roids. The 1 in 100 may probably have just lucked out in being at the right place at the right time.

Transdermal Nitric Oxide products would be worth a try:

Transdermal NO would be good in the sense that apart from vasodilation it influences tissue relaxation positively and collagen excess negatively. That said, for tunica purposes it would be tough to reach from a topical since it is naturally impermiable.

I’m not saying it can’t be done, and I’m sure there are at least a couple of ways of doing it. It’s just that to automatically assume that an off the shelf product would be right for the job is wide open to confrontational precedent.

I’ve been ordering a boat load of different substances lately and will begin some experimentation in the new year. To be honest I’m not very optimistic about any of them, but the curiosity factor is enough to override the sensible pessimist in me.