I’ve tried a couple of lotions from boots (forget the names) that are supposed to be used for aching muscles. I can’t be sure what they did, but subjectively it felt like a chinese burn rather than actual temperature elevation. I didn’t really think much of them though.
I think vit-E may be useful but not groundbreaking. I went into the collagen idea a couple of years back thinking that the idea would be to increase collagen production (more tissue generation=bigger tool?). Once I started reading though I completely turned about face on this. The best information I’ve ever found was in reading about pregnancy and cervical ripening. There is a complex sequence of events approaching full term which involves a combination of some prostaglandins (PGE-1, PGE-2, PGF-2a etc), hyaluronic acid, collagenase, and a whole host of other components that allow primarily Type I and III collagens (CC is mainly Type I & IV), and some smooth muscle to relax, where the collagen thins out and the bundles can unlink and slip allowing dilation.
Some ripening techniques employ a baloon catheter which can stretch the tissues over many hours. In our case that could equate to clamping or extreme pumping. The trouble is, to do this we have to restrict bloodflow. Restricting blood flow causes a rise in TGF-B1 which promotes collagen and stabalises the whole trauma area. To make matters worse it reduces PGE-1 which is beneficial in relaxing collagen and causing the erection. This has a dual effect of causing smooth muscle to waste away while there is a collagen over production which can cause tissue stiffness, or in the extreme even ED.
PGE-2 is another prostaglandin that may be useful (if in the correct tissue types). Relaxin is another (although human relaxin seems ineffective while porcine relaxin seems very effective - don’t know why).
It would seem to me that a multi-staged approach of collagen degradation/turnover, extension, followed by a long period of recovery (deconditioning if you like) would be quite effective. Depending on tissue types, if may have adverse effects on the skin if topical so it could be important to administer differently, or at least avoid stretching the skin. I don’t know if this is chemically or biologically possible, but suspect that anything very effective would also be very prone to disasterous consequences. If we had a mild cream that would lean gently in that direction ( like the original stretch-mark cream proposal) then there may be a solution out there.
It may be as simple as a combination of DSMO with misoprostol (an ulcer drug used off label) along with PGE-1 would do the trick. As much as I consider myself a risk taker in PE, I don’t feel comfortable in trying something like this because of possible irreversible consequences and general lack of knowledge.
Now that I’ve frightened everyone with the risks, and mentioned a little about the areas explored, I hope that it’s clear that I’m not talking about ‘just another lube with some arginine and horny goat weed’, but a genuine targeted (but mild) smart bomb that targets just the appropriate tissues, and the worst case outcome would be a run to the toilet for a flock of seagulls.
I don’t know if this is a bit hardcore for most, or if it’s just a bit hard to fathom. If there’s enough interested then I’m up for researching it, but done alone it could take several lifetimes.