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Is the plateau caused by fibrin and factor XIII?

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https://pubmed.ncbi.nlm.nih.gov/262335/

Factor XIII itself might play a role in the hypothetical changes to the collagen of the plateaued penis via its cross-linking abilities.
How do you suggest the cross-linking happens in the factor XIII direction?
I can’t find something I can understant about this factor and it’s activation. “It is activated by thrombin to factor XIIIa. XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and increases bleeding tendency.” this is the only google def I understand a bit.

Originally Posted by Sigmoid
In Peyronie’s disease, which may or may not be similar to the the plateau, aberrant fibrin deposition is detected most of the time in histological samples.

Fibrin is a blood clotting factor, it is normally dissolved by pre-embedded plasminogen (when activated it is called plasmin), however it can be prolonged in the presence of plasminogen activator inhibitor and it can bind to collagen via factor XIII. You can think of fibrin as temporary collagen.

Factor XIII is a crosslinker, it connects two pieces of connective tissue, like fibrin and fibrin to each other in a new way not part of the self assembly mechanism or fibrin to collagen.

https://pubmed.ncbi.nlm.nih.gov/262335/

Factor XIII itself might play a role in the hypothetical changes to the collagen of the plateaued penis via its cross-linking abilities.

What if in the case of the plateau, chronic PE causes fibrin to bind to collagen, reinforcing it in a shortened state negating gains, and an upregulation of plasminogen activator inhibitor makes the normally temporary clotting structure semi permanent?

What do you guys think?

There’s a whole range of ideas thundersplace hasn’t explored yet, real nitty gritty aspects of connective tissue. I’m trying to gradually roll out these new subjects, past experience tells me unloading too much information at once causes aversion since people feel overwhelmed. I figure the more people know about the ins and outs of the tissues of the penis, the faster we can sort out a safe way to defeat the plateau phenomenon.

Correct me if I’m wrong but are you saying having factor eight deficiency can promote plastic deformation? If so, how can we support this idea with science and test it?


Life goal: 9x7 inches of pure raging steel, with a small patch of decorative grey hairs.

my thought on all of this for the last 17 years is that the amount of blood in our bodies limits the size of penis. If we grow our penises too large, do we have enough blood to adequately fill it for an erection AND still be conscious and not pass out? I haven’t looked this up or looked into it at all, but its always been my thought on plateaus in PE


Starting length, Spring 2003: bpel 6 3/8", bpfsl ~6 1/2", flaccid ~3-4" (never measured flaccid stretched or hanging flaccid; starting girth was probably ~5"-5 1/4")

Summer 2004: bpel 7 7/8", bpfsl 8 1/8", flaccid ~4", erect girth 5.3"

Spring 2018: bpel 7 1/4", bpfsl 7 5/8", erect girth 5 1/8"; Spring 2020: bpel 7 3/4", bpfsl 8", erect girth 5 3/8". Current - August 2021: bpel 7 3/4", bpfsl 8", erect girth 5 1/4"

Originally Posted by pumpedmember
my thought on all of this for the last 17 years is that the amount of blood in our bodies limits the size of penis. If we grow our penises too large, do we have enough blood to adequately fill it for an erection AND still be conscious and not pass out? I haven’t looked this up or looked into it at all, but its always been my thought on plateaus in PE


We covered this in another thread recently, but I’ll repost the high points.

A 180lb body has about 1.5 gal (5.7L) of blood. The volume goes up or down depending on height, weight, etc. A pregnant woman will have 50% more blood than when not pregnant. The body makes enough blood to ensure proper functionality of all its parts.

You will exhibit mild side effects like nausea when you lose from 15-30% of blood volume. You will lose consciousness when the body has lost 30-40% of blood volume. Death occurs around 50% of blood volume loss.

There is absolutely enough blood in the body for whatever size dick you have to get erect and you won’t become unconscious. If you see a huge dick in porn having trouble getting hard, it is not a blood volume issue.


Initial: 7” BPEL; 6” NBPEL; 5.25” - 5.5” MEG

Current: 7.5” BPEL; 7” NBPEL; 8.25” BPFSL; 6.25” - 6.5” MEG w/ c-ring.

Goal: Improved/consistent EQ while managing ED. Secondary: maintain current stats.


Last edited by 32quarters : 07-08-2020 at .
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