Questions For Those Who Have Used PGE1 (CAVERJECT)

They do have a website

It’s very legit and professional and licensed etc etc

They walked me through it but I had done so much research it was all just stuff I’d already read a million times

One of the cool things is they have the antidote for you which they ship out with it

I was hesitant to go black market at least partially because I couldn’t find the antidote black market

What is the antidote? I’ve heard Sudafed but is there a better one? Also, how has pge1 worked out for you? Do you feel you’ve made any gains from it. I’m thinking about using it on the nights I crank my hgh dose up a little bit.

The antidote is injectable phenylephrine. Works way more consistently than Sudafed and much, much quicker. Reverses the erection in a minute or less.

I got some trimix, haven’t used it yet. Those that have used it, would you describe the erection similar to what you experience while clamping?

Yes and no in terms of clamping. Like clamping, the Trimix erection is super hard and eventually becomes uncomfortable. Like clamping discomfort, I think some of the Trimix discomfort is related to the pressure on the tunica, which can be extreme and unyielding.

I also think some of the discomfort is a degree of intracavernosal hypoxia, as it shows up some time after the 2 hour mark and seems to increase over the session. On the occasions when I’ve had to inject the antidote that particular discomfort resolves as soon as the deflation begins and some degree of normal inflow of blood is returned.

Unlike clamping, the super hard only involves the CC and not the CS unless you are actively sexually aroused or wearing a c-ring. When aroused the CS expands to the degree you are, which varies like a normal erection. So a Trimix erection can be a little weird with super hard CC and a soft, deflated glans and CS if you’re not turned on.

Even when fully aroused I’ve noticed that the distal ends of my CC that are enveloped by the glans are so hard that penetrative sex can feel a little uncomfortable as its almost like there isn’t enough padding by the glans to cushion the impact of the steel hard CC tips on the deep thrusts. But the tradeoff is that the vaginal pressure on the sides of the penis on the strokes is amazing when your CCs are 100% expanded and rock hard. It feels unbelievably great, especially if your partner has some muscular control and can squeeze a bit.

I am mostly using Trimix as a supplemental component of my PE regimen, which is why I target longer duration erections with my dose and notice the difference between aroused and unaroused, but if you are dosing less for a session of sex (say targeting about an hour of erection time) then you might be turned on the whole time you are using it and won’t spend as much time in the unaroused state. So you might not notice this.

Also like clamping, I find I have a lot of fullness on the flaccid hang post session, but the effect is more pronounced. It’s like a semi and it lasts hours. I’m not sure if this is because of the duration of my Trimix sessions (I average 3-4 hours) causing some internal swelling with the CC tissues or a lingering partial effect as the drug wears off, but it is definitely noticeable.

I’m also on a hair trigger for a long time after, up to 12 hours, where I can instantly get erect with almost no mental or physical stimulation. Which is both fun and challenging, depending on the circumstance…

Thanks for the info

What TD said! I know for my experiment I concluded that the Trimix creates tunica strain from within, compared to pumping that exerts pressure from (in large part) the outside. I used the Tri to get that rock hard diamond erection, then added gentle (low pressure) pumping to really stress the tunica. Believe me, you feel it, and pay attention to pain levels.
As TD says, one tail effect is the ease of later erections, including overnight. I have experimented as well with PT-141 at a low dose before bed following a Tri day. Holy crap the nocturnal and morning wood is astounding. I know Igigi experimented with lower dose Tri (or similar) overnight to also induce longer term sleeping expansion. And the morning “benefits” can be fun!

A more technically and safety conscious member observes:

Trimix helps increase pressure inside the penis (tunica to be more precise) until the inside pressure is greater than the outside pressure. The higher internal pressure creates a force acting against the resistance (tunica) pointing outward. The outside penis pressure is fixed and you are increasing the internal pressure with the injection.

A vacuum pump decreases pressure on the outside of the penis until the internal pressure is greater than the external pressure and the force again moves outward. The internal penis pressure is fixed and you are decreasing the external pressure with the vacuum pump.

Same exact mechanical principle in both methods.

The difference in the two would be that the trimix is probably more focused on the corpus/internal to the tunica whereas the vacuum pump impacts the fascia tissue external of the tunica which more easily allows edema buildup.

His explanation is far more precise than mine from a scientific standpoint. What I experienced was the extra strain from within, then furthered by GENTLE added pumping, and not for long periods. The safety issue is real I think by comping the two, my point being you will know it (pain) if you are over doing it. Not for any beginners for certain.

There may be a post that I have missed to explain the details. But please help me with these questions. Many many pumping sessions are needed before you see any kind of lasting or permanent changes, so how many sessions with chemical PE are needed before you see changes? I may be totally off here, but if I understand correctly, you’re basically creating a scenario that a person with sickle cell might have, we’re basically you put up with the pain for as long as physically possible, not to go over four hours is this correct? And do you have any suggestions based on dosage to achieve this?

Can this desired effect be easier achieved with the combination of viagra or Cialis?

Chemical induced priapisms are high flow priapisms

The blood is constantly flowing

It’s chemically induced high blood flow

I don’t think pain comes from hypoxia, but rather, just general fatigue and soreness that the muscles aren’t used to, and there really isn’t any danger to extremely long erections except the extreme pain

Sickle cell causes low flow priapism - its really something completely different, and while it can cause increased penis size, it’s also very dangerous and unhealthy, and can damage the penis

I used a shit ton of trimix to cause erections back when I was addicted to stimulants, because I couldn’t get erect while using them. My experience was that generally speaking my penis actually shrunk a bit in size after the sessions and it would require a week or so of PE to get it to return to regular length

My thoughts were that the injection and other trauma associated with it causes the tissues to atrophy somewhat

Sickle cell anemia causes occlusive ischemic priapism because the abnormal blood cells clog the small vessels. You’re right that it is totally different in terms of mechanism. But the final common pathway is the same for all prolonged priapism, which is ischemia leading to intracavernosal scarring and fibrosis. Eventually the small vessels are clogged by static, sludgy, clotting blood. This requires a prolonged, high-tension erection.

You’re right that PGE-1 induced erections are generally high flow, but they can progress if severe and prolonged. They can progress to ischemic priapism, as described above. Prolonged medication-induced priapism is documented to be dangerous. The urologic literature says greater than 24 hours. Above 36 there is ischemia-related fibrosis which requires surgical intervention. Of course this is severe, and the 4 hour precaution quoted by doctors is conservative based on clinical data, but I get why prescribing docs are conservative. They prescribe the meds for ED and a 4 hour erection is more than pretty much anyone will need for routine use ;) Why risk a complication? But I get your point about the risk being low. I’ve never come close to it, but at 7-8 hours I am begging for mercy and at that point I’m not waiting to see if I can come down by the 24th hour.

While I can’t say with certainty that the discomfort is hypoxia related without doing an IC blood gas test, and I could definitely be wrong, for me it does kind of feel like exercise-induced anaerobic tissue discomfort, at least the cavernosal equivalent. The fact that it resolves almost instantly with phenylephrine-mediated detumescence makes me feel that is a possibility. But I’m not making a definitive claim.

Explain what you mean about muscle soreness? The only muscles involved in the CC are smooth muscle lining the sinusoids. There are the bulbospongiosis and ischiocavernosis muscles related to the penis, but they are external to the CC. I’m no expert, and so I’m interested to think about your perspective on this point.

I haven’t experienced and post session shrinkage. In fact the opposite, but I am using it in conjunction with a PE program designed around it.

Like any PE program, there is no defined amount of sessions or time to guarantee results. This is all based on theory and some small amount of anecdotal evidence. Some guys report gaining really fast on this method. Others not at all. As with all of this stuff, methods and results are self-reported. The pool of people who have reported on it is very small, so we can’t really draw too many conclusions as to whether it works or not, or why it does when it does.

The theory has been described on several threads, but essentially boils down to two considerations:

1. The PGE itself may have some biochemical collagen delinking activity, which potentiates gains from PE exercises above the exercises’ capacity to promote gains alone. (Personally I’m not sure how much this is at work. The doses of PGE-1 on Trimix are really low and some pioneers who claimed to have achieved gains used Trimix rather than straight PGE-1, presumably with really low PGE-1 doses.)

2. The intense pressure on the tunica from repeated 3-6 hour sessions is like an internal ADS, potentiating and cementing gains from a PE exercise program.

So the idea of using PGE-1/ Trimix is to augment the intensity and duration of PE from internal pressure on the tunica. We aren’t trying to create priapism duration to create ischemia that would lead to pathologic expansion, like those unfortunate men who suffer from SS priapism sometimes get. But rather we are trying to create super hard, prolonged erections that push on the tunica from the inside and don’t detumesce for several hours no matter what we are doing. So no or less need to self-stimulate.

So a low pressure pumping or clamping session on top of that high tunica pressure leads to even higher pressure. The hope is the opportunity to stack the clamping or pumping on top of the Trimix erection could make a difference in terms of expanding the tunica. Newyorktexan has had some results. I’m hoping for the same, but my early gains are just that and its too early to say if they will be permanent.

I’ve never come close to this kind of erection on viagra or cialis, though my viagra experience is relatively limited as I get severe headaches and nasal congestion with it. I take daily cialis for a variety of health reasons, along with the EQ benefit, and am also on TRT. So I can get erect really quickly and easily. But as hard as that can be, it’s a different quality than a full Trimix erection. On oral ED drugs the erection will fluctuate a bit, even when fully erect. With Trimix the CC are diamond hard and don’t fluctuate until the drug starts to wear off, the duration of which is dose dependent.

Again this is all hypothesis and my perspective. Maybe someone else has a different view, and I’d be interested to hear it.