Again, 4AD converts to 3alpha(a DHT derivative) in the penis. Androstanediol(3alpha), may be active. Or 3HSD may change it to DHT. I speculate that the slow diffusion through the skin causes the appearance of elevated androgens in the penis.
I never said I was using that product. I dissolved 4AD powder in alcohol, then added IPM. It is widely considered to be a very effective trans-dermal delivery system.
nearlythere: “Or it might just irritate the crap out of them.” I contend that my explanation is much more plausible. In fact, it is widely thought that when Androgel is directly applied to the scrotum that it has an enhanced suppressive effect.
Testosterone synthesis is suppressed, the extent is not discussed. The fact that it is temporarily suppressed, is stated. If trans-dermal androgens is not effective, why has this published medical study explicitly stated that it is effective? Yes, I know they are younger. It still proves the efficacy of a topical trans-dermal method.
Transdermal dihydrotestosterone therapy and its effects on patients with microphallus.
Choi SK, Han SW, Kim DH, de Lignieres B.
Department of Urology, Yonsei University College of Medicine, Seoul, Korea.
To investigate the efficacy of transdermal dihydrotestosterone therapy on 22 patients with microphallus, we applied dihydrotestosterone gel for 8 weeks to the external genitalia at daily doses of 12.5 mg. and 25 mg. for ages less than and older than 10 years, respectively. All patients were evaluated for penile and prostatic growth, pituitary-gonadal axis function, serum sex hormone binding globulin, lipid metabolism, hepatotoxicity, bone age and height velocity. All patients demonstrated growth of the penis during treatment. The mean increase rate (153%) in the first 4 weeks of treatment was higher than that (118%) of the second 4 weeks. Of importance is that responses were noted in 4 patients who had failed testosterone therapy for microphallus. The pituitary-gonadal axis was transiently suppressed during treatment, and serum sex hormone binding globulin and lipid metabolism were transiently affected during treatment. Serum alkaline phosphatase increased, mainly due to change of bone isoenzyme but bone ages and mean height velocity were not significantly affected. In conclusion, transdermal dihydrotestosterone therapy is an effective and relatively safe modality in the treatment of microphallus.