Topical Chemical PE

Try lemon juice instead than DMSO. At least if it doesn’t work your gf will like more giving you blow-jobs.

I don’t know. Lemon can be pretty sour :)

Uhmm….than try it if your woman feels loose down there.

yes. But the systemic effect will no doubt be less, if the area of application is temporarily occluded (clamping/tight-cockring/etc), no?

Out of curiosity, what is the active life of DMSO in either tissue or the bloodstream, when it is systemic?

Yes, the neuro degenerative effects of large DMSo doses, is the #1 reason why i would be much more enthusiastic with using another, albeit slower, transdermal solvent, perhaps a less toxic one with maybe less efficiency. To your knowledge, what other, safer transdermal delivery methods exist fbesides DMSO, for molecules with a molecular weight between 300-400 ?

:rolling:

Which ‘neruo degenerative effects of large does DMSO’ are you thinking of?

It has been shown, even in low doses…..brain degenerative effects in rats subject to testing it’s safety.
And while i am interested in it’s abilities, and their applications for PE, i do not want to risk any cognitive damage, no matter how miniscule.
Perhaps if DMSO’s life in tissue and the bloodstream is of short duration, a simple occlusive measure, such as clamping/cockring, around the base of the cock might suffice to keep the DMSo from going systemic? In addition to the occlusion maximizing the localized effects of the accompanying solute, i.e. tadalafil/igf/pge dose? is this correct?

also, reiterating the pertinent questions hoping someone can answer:

DMSO exposure to developing mouse brains can produce brain degeneration.[13] This neurotoxicity could be detected at doses as low as 0.3 mL/kg, a level exceeded in children exposed to DMSO during certain medical treatments.

Glove selection is important when working with DMSO. Thick rubber gloves are recommended. Nitrile gloves, which are very commonly used in chemical laboratories, have been found to dissolve rapidly with exposure to DMSO.[14] Because DMSO easily penetrates the skin, substances dissolved in DMSO may be quickly absorbed. For instance, a solution of sodium cyanide in DMSO can cause cyanide poisoning through skin contact.[citation needed] DMSO by itself has low toxicity.[15] Dimethyl sulfoxide can produce an explosive reaction when exposed to acid chlorides; at a low temperature, this reaction produces the oxidant for Swern oxidation.

Recently, DMSO disposed into sewers caused odor problems in cities: waste water bacteria transform DMSO under hypoxic (anoxic) conditions into dimethyl sulfide (DMS) that has a strong disagreeable odor, similar to rotten cabbage.[16]

Dimethyl sulfoxide - Wikipedia

LOL exactly.
I’m very health conscious as it is, and thoroughly paranoid, doing excessive reading when it came to putting together a regimend of Herbal supplements, so I’m double noid when it comes to man-made synthetics of some level of toxicity.
But yet I’m still very interested :) lol

DMSO may have great efficiency and lightning quick action, but God be blessed if there is something slightly safer that can work 1/2 as well with molecules w/ molecular weight up to 400. please someone come thru with another reputed transdermal carrier *crosses fingers*

Probably not a good idea. Citrus juice is used to cook raw meat. Ever hear of ceviche?

Ceviche - Wikipedia

"Ceviche is marinated in a citrus-based mixture, with lemons and limes being the most commonly used. In addition to adding flavor, the citric acid causes the proteins in the seafood to become denatured , which pickles or "cooks" the fish without heat"

Marinera, are you saying that if you apply DMSO mixed with crushed potaba topically it will burn through your dick? Members here have applied DMSO to their dick and I’ve never heard of them reporting these side effects you claim DMSO has.

Where I said that? :confused:

Wow! If it has such a bad effect on proteins I wonder why they use citric acid in some body building (cutting) supplements? Sure, it might help burn fat but what about it’s effect on proteins?

I use to drink lemon juice quite often, and it has never cooked my tongue.

And by the way, I was just joking in the post you quoted, I don’t think lemon juice can make the penis bigger. :)
Guess everybody got it.

The article cited by Marinera focuses on developing, eg, young, rat brains and is in relation to possible adverse effects on children.

"Further work is needed to determine whether even older animals are sensitive to DMSO’s pro-apoptotic effects…. Given that we observed apoptosis even at the lowest dose tested, 0.3 ml/kg, exposure to DMSO during transplantation could be producing similar damage in children…. Two published studies (Authier et al., 2002; Fossom et al., 1985) report behavioral effects of DMSO but these studies were done in adult rats when it is unclear whether DMSO-induced apoptosis occurs."

I may be misinterpreting the discussion or just plain wrong, but it seems that this study is basically focussed on how DMSO induces apoptosis of developing neurons, eg those found in baby rats or by extension, children. The study says that the damage caused by ethanol in developing brains is the same type as caused by DMSO:

"Ethanol is the most extensively studied of all the agents that have been found to produce this type of damage in the in vivo rodent…

Given that a brief exposure to ethanol produces apoptosis in non-human primate brain (Farber et al., 2005), the infant human brain might be at risk of developing apoptosis with similar exposure. Studies to further clarify the risk to human infants are needed."

Dimethyl Sulfoxide (DMSO) Produces Widespread Apoptosis in the Developing Central Nervous System - PMC

What I got from reading the discussion, basically, was that the study was concerned with damaging developing brains by a mechanism similar to how ethanol damages children’s neurological development, which is well known and studied. What I draw from that, then, is that DMSO, like alcohol, shouldn’t be given to children, but if you drink alcohol, as an adult, then DMSO isn’t likely to do any more harm than that alcohol does, if any. In fact, if you compare the amount of ethanol you’re likely to imbibe on any given bender you’d probably find it comparable to the total amount of DMSO you’d absorb transdermally over the course of your whole PE career.

Futhermore, it seems these possible neurological effects on children have nothing to do with why the FDA has thus far refused to admit DMSO, as discussed here: DMSO: Many Uses, Much Controversy