Topical Chemical PE

Did my best to skim through the chem PE reports, all sounds well and good but I don’t want to keep the world of penis completely separate from the world of sharp, pointy injecting needles.

I’ve seen a few posts in other threads about the idea of a topical chemical PE type method. Goonbaby did quite a bit of research in
Collagen Considered, but then that thread seemed to trail off and nothing became of it.

What I am basically interested in is trying to use DMSO (a powerful solvent that can easily transport other molecules transdermally (hopefully into the tunica and beyond) with potaba and/or pentoxifylline. My research seems to tell me that potaba will relax collagen cross-linking but I’m not sure about pentoxifylline, does anybody know?

Also I’d like to what what volumes we’d be talking about for a topical application of potaba/pentoxifylline with DMSO, like, concentrations and total amount that hould be applied, etc.

Potaba can be bought in relative bulk here - but it’s in a salt form, is that okay for my purposes? Otherwise I’d just be buying it elsewhere and crushing it up into a powder before adding it to the DMSO.

The site I’ll probably use to get DMSO is but again, I’m not sure about which one to get.

I’d appreaciate some advice, if anyone can help :)

Take Care! ;)

I will of course be taking the utmost care while experimenting. It’s just a shame I don’t have any pets otherwise I could take even more care, from a human perspective at least.

It seems I can’t get potaba without a prescription, even shadily online.

I am also interested in Verapamil, which as claims of being able to reverse peyronie’s disease and affects how new collagen forms including its attachment to ECM and such (http://www.natu re.com/ijir/jou … l/3900917a.html ).

This study says topically administered verapamil does not penetrate the tuncia.

Transdermal application of verapamil gel to the penile shaft fails to infiltrate the tunica albuginea - PubMed

But I wonder if combining it with DMSO might be more successful? Verapamil’s molecular mass is also a bit more (~550) than potaba but I think it would still carry it. I saw somewhere that even 70% DMSO can penetrate through to the bladder from (I assume) topical application. If that’s the case then it shouldn’t have any problems penetrating the tunica, I think.

More on pentoxyffilin, which seems to be able to alter collagen expression and structure, particularly of type I collagen (which I believe the tunica is largely made up of) and active fibroblasts of concern:

http://www.burn sjournal.com/ar … 0367-7/abstract

Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis | Gut

finally: "Pentoxifylline attenuates TGF-beta1-stimulated elastogenesis in human tunica albuginea-derived fibroblasts Part 2: interference in a TGF-beta1/Smad-dependent mechanism and downregulation of aat1"
- Pentoxifylline attenuates transforming growth factor-beta1-stimulated elastogenesis in human tunica albuginea-derived fibroblasts part 2: Interference in a TGF-beta1/Smad-dependent mechanism and downregulation of AAT1 - PubMed

I’m not 100% on what that means, but reduced elastogenesis could be useful for my purposes. I mean I feel a bit stupid, having worked in microbiology and cellular vascularity labs before, this type of PE is kind of like hitting myself with a sledge hammer and trying to record the objective results, based on already somewhat shakey hypothesises. But then again, I’m not looking to get published, I just want to prove to myself that it works or does not work, which I believe I have a half decent shot of doing.

Regarding Pentoxifylline, there seems to be the oral pills you can take just the oral pills for potaba but is that what you’re looking for or is there also a topical solution for Pentoxifylline?

Lol, good thing you don’t have pets. Who knows what the RSPCA would say. :)

What could the consequences be if it doesn’t work? Like I mean, worst case scenario.

It was only a joke I would never subject a pet to my own twisted world of penis experimentation!

Regarding pentoxifylline, the pills are available and there is also a topical version available but I lost the link for it.

Regarding verapamil, I haven’t actually seen any articles on the topical application of it. While I’m confident DMSO would carry it, since no one’s done it before I’m probably not willing to be the first.

The more I read, actually, the more discouraged I’m getting. Verapamil and pentoxifylline are both quite expenisve and in pill form, so I’d have to crush them to a powder then add them to DMSO.

Worst case scenario is penis falls off, before trying any of these chemicals on my penis I’d try them on another area of flesh such as finger or arm or ear lobe :p

So I think for now I’m just going to get some 70% DMSO gel and experiment with it with some PE exercises. I actually saw a few threads of MoS and PEgym about guys who’ve been using it with PE for ages and love it. I would be interested in applying it and then doing an extended pump session (1h +) at very low pressure. But since I’m not an experienced pumper, that experiment will have to wait.

I’m interested in your experiment. I don’t have much to say about this , as I didn’t research much on those, but I would like to know about the (positive) outcome. Hope you achieve what you want.

How would you add potaba to the mix of DMSO topically, would have to crush the tablets into powder? So for example, you apply the DMSO gel and then spread the powder of potaba pills over your penis as well?

The only negative side effect I can find about the DMSO gel would be the smell. But if DMSO is just used to better transmit other substances beneath the skin then what benefit does it have on it’s own regarding penis enlargement?

I myself use the penis pump and wondering if it would be wise to use the gel after or before a pump session.

Pumping may be a good combination with this approach since it’s expanding the penis in a state where the potaba might make it even more expandable.

Don’t know for sure though, check out this guy’s blog http://www.chem … 01dfc4258cf8550 He charges 50 dollars for a consultation on a program that worked for him but I got a free consultation from him. I used pay pal and said that he took too long to get in touch with me so he ended up giving me the consult for free.

He is pretty vague in his post because he wants to give out the information in the consult but if you already have an idea of what he’s talking about on his blog you probably won’t even need the consult. Anyways when I spoke to him on the phone, he seemed very honest and real about the gains but admitting the only draw back was the price he spends monthly.

Information is out there I guess we just have to keep looking. I wish everyone the best and safest

I would crush potaba/pentoxifylline/verapamil very finely and dissolve it in pre-aliquotted amount of liquid DMSO, then apply a measured amount of that solution evenly to my penis. Instinctively I would apply it 10 or so minutes before PE. I believe stretching/hanging or pumping/clamping would have then have a more pronounced (and hopefully) positive effect on growth.

Ah that’s the ‘gay male escort’ service guy lol. I came across his page before. He injects with methods described in these threads
Chemical PE Links). If you want to inject all the info is already on Thunders, that thread links to most of it. But then you’re talking about injecting suttf like PGE-1, IGF-1/IGF1-LR3, and other stabalising and activator chemicals, and it becomes much, much more complex as well as much, much more expensive. On the plus side it’s been done before with amazing results for some individuals, though personally I believe it’s even more dangerous than topical chemical PE even though it hasn’t been done before.

This thread is about topical chemical PE, that is, applied to the skin of the penis.

Have you looked up the thread on EVO oil?

Keep reading. :D

I’m sure there are ways out there that may speed up gains by 10% or so, but I think it far safer to spend 10% longer to get gains without chemical means.

Remember that anything that penetrates through the dermis ends up in your bloodstream and is carried all over the body (I’m not teaching you to suck eggs Tweak, it’s for everyone’s benefit). Connective tissue has so many roles to play in the body, including the 3 layers around the brain, in the heart and lungs, etc. and things that mess with the structure of connective tissue usually do it by messing with the immune system. With your background you know the problems with that Tweak. Is it worth the risk, just to save a couple of months of work?

If you want the safest and most effective way to soften connective tissue, read my sig line.

Yes I was surprised to learn DMSO can actually permeate even the BBB, gave me a shock for a moment there, but everything I read about it seemed to be positive anyway.

I’ve also been reconsidering my motivation for exploring this avenue, and, yes, ultimately, the first explanation that comes to mind is ‘impatience’, which I’m very good at preaching to other people about avoiding! After all I’m still young in my PE career. Nevertheless, I am going to purchase some DMSO and see how it feels on my skin. At the very least, it seems to have a huge number of other non-FDA approved medicinal applications that naturopaths have been touting for ages.

Per your advice I looked up the threads on EVO oil. Don’t see particularly how it applies here. There’s too many constituents in EVO oil for me to want to combine it with DMSO, no idea how transporting some of those things across some cell membranes would have repercussions.

I am very interested in learning about transderaml application for many things, for one tadalafil, as I wish to keep PDE5 and PDE11 inhibitors out of my non-sexual organs, even though there are currently no dangers associated with this, I still wish to learn more to use transdermals to localize effects more, and stay way from systemic effect.

If it ain’t broke, don’t fuck with it :)