Why gains slow!

Damn, I can’t tell an ovary from a penis. That’s what I get for a rapid search and post.

Here’s an article that nicely summarizes a lot of the studies we’ve mentioned in this thread and perhaps suggests some treatments for combatting over conditioning:

http://www.curr ent-reports.com … ticle&KeyWords=

Here’s more on our friend the armadillo:

http://www3.int erscience.wiley … /50603/ABSTRACT

The full text is not free. It may contain more detail on the tunica’s actual structure than I (we) have seen before. But I’ll wait to see what I can learn from the previous article I ordered before I think about paying for this one.

In my search for collagen inhibitors I have found this. Fasting can inhibit collagen synthesis. Maybe we can figure out how to mimic this in our dicks.

http://www.ncbi .nlm.nih.gov/en … t_uids=12670795

Comp Biochem Physiol B Biochem Mol Biol. 2003 Apr;134(4):703-11. Related Articles, Links

Expression of IGF-binding protein-1 phosphoisoforms in fasted rat skin and its role in regulation of collagen biosynthesis.

Cechowska-Pasko M, Palka J.

Department of Biochemistry, Medical Academy of Bialystok, 15-230, Bialystok, Poland. m.pasko@poczta.fm

Insulin-like growth factor-I (IGF-I) is an important stimulator of collagen and glycosaminoglycan (GAG) biosynthesis in tissues. IGF-I activity is modulated by a family of IGF-binding proteins (IGFBPs) with different IGF-I binding affinities. At least IGFBP-1 and IGFBP-2 are known as inhibitors of IGF functions. Some IGFBPs (IGFBP-1, IGFBP-3 and IGFBP-5) may undergo phosphorylation that dramatically increase their affinity for IGF. During fasting of animals there is a significant decrease of the collagen and GAG content of the skin, accompanied by a reduction of plasma IGF-I levels. However, in previous studies we showed that in the skin of fasted rats IGF-I as well as IGFBP-1 and IGFBP-2 expressions were not different, compared to control rat skin, although collagen content was significantly decreased. In the present study we show that fasted rat skin contains similar amounts of IGF-I, IGFBP-3 and IGFBP-1, although extract from fasted rat skin induced inhibition of collagen biosynthesis in cultured fibroblasts, compared to control rat skin extract. Western immunoblot analysis of control and fasted rat skin extracts, using anti-phosphoserine antibodies for immunoprecipitated IGFBP-1 and IGFBP-3, revealed that both proteins are present in phosphorylated form. Although no differences were found in the expression of phosphorylated IGFBP-3 between control and fasted rat skins, that of phosphorylated IGFBP-1 in fasted rat skin extract was higher than in control one. We suggest that there is an increased level of IGFBP-1 phosphoisoform in fasted rat skin, associated with increased affinity for IGF-I. The increase of phosphorylated IGFBP-1 in fasted rat skin tissue may augment IGF-I binding affinity for IGF and decrease its bioavailability for receptor interaction. This mechanism may prevent IGF-I dependent stimulation of fibroblasts to produce extracellular matrix components. The specific expression of IGFBPs and their phosphoisoforms in tissues may play an important role in regulation of IGF-I action during physiologic and pathologic responses.

PMID: 12670795 [PubMed - indexed for MEDLINE]

Here is a list of articles on the subject:
http://www.ncbi .nlm.nih.gov/en … om_uid=12670795

If you don’t post very soon, there will be no breakthrough. I sent you a PM awhile back concerning this. I would send you another but they seem to be disabled on you account. I will start a stretching routine with penile DMSO soaks in a few weeks at the most. If you want, I will wait a reasonable amount of time for you to start a thread.

Let me know.

DMSO may be very dangerous to use while doing PE. It may digest the collagen that is the structural support of veins and arteries.

Example of injury possibly due to DMSO usage:

Encouraging/Frightening DMSO experience

Kids know better, my little cousin told me the penis is made up of loosely connected bone cells that have compartments like sponges. Hence spongy bone. Lolz

Any more developments Gentlemen?

My interest is still on this topic and I will try and get the ball rolling again as soon as I have the time.

Are you still deconditioning and taking stuff to clear up collagen, penismith?

I am.

Well, I hate to admit it but I have not been great about my deconditioning routine. I am still taking the alpha lipoic acid and the acetyl L Carnitine and doing some infrequent deep tissue massages. Some of the bumps are still there.

I am sad to admit that my penile skin fading seems to have halted. I am sure it is still fading, it is just at such a slow rate that I can’t tell the difference. I tried DMSO saturated with vit C one day and will probably try with ALA at some point.

I have not resumed my exercises during this break. I have lost a little erect length, maybe 1/8 inch, but I lost that in the beginning of this break so I think the rest of my length gains are solidified.

My girth has stayed the same. I am happy to see that my previous girth gains seem to be very well solidified. If anything, I think I gained a 1/8 inch which is not unheard of during a break.

When I resume (I don’t know when) PE. I will probably work with a IR pad. Hobby has a brilliant thread that backs up Bib’s “cool in the extended state” concept. I plan on, like Shiver, getting my penis very warm with the IR pad, stretching it to its maximum and then cooling in the extended state to break bonds. IOW, I am retiring the rice sock for bigger guns.

Wish me luck!

The worst thing about the IR pad routine is that you feel guilty that it takes so little effort compared to what you read everyone else is doing :D

Please elaborate. I want to learn all I can before I spend money I don’t have on the pad.

I am also considering trying to develop a routine around the tenderizing effect that Hobby and Piet have been talking about.

I have read a little on collagen crosslinking and so far it seems to me that vitamin B1(Thiamin) is a crosslink breaker / Inhibitor, as is L-carosine a Crosslink breaker / inhibitor, and L-cartanine is an inhibitor, I don’t know if this is any good but Lethacin helps with the creation of collagenese in the liver and that supposedly helps to remove fibrosis. Also (Magnesium + vitamin d3) I’ve read increase smooth muscle and elastin cell regeneration / proliferation.