Inhibiting collagen cross-linking for increased gains

I thought my account was older so I could post in other forums, guess not.

Anyways, I perused across this drug called beta-aminopropilenitrile (BAPN)
https://en.wiki pedia.org/wiki/ … nopropionitrile

It was discovered in peas, as those who were reliant on certain strains acquired developmental issues by a disease called Osteolathyrism
https://en.wiki … /Osteolathyrism

If one were to dose BAPN, or eat these peas, could you increase penile length gains by say, hanging? So I googled it and I came across this abstract:

AB041. Anti-Lysyl oxidase combined with vacuum aspiration induce penile lengthening by tunica albuginea remodeling

Tao Li, Fudong Fu, Changjing Wu, Feng Qin, Qiang Wei, Jiuhong Yuan

Background The penile length is from the pubis to the end of glan of the stretched penis, which is mainly defined by the dimension of cavernous body. Micropenis is generally defined as penile length below two standard deviations of mean value. There is no treatment with solid evidence in clinic. Our previous study found the expression of Lysyl oxidase (LOX) is downregulated with aging. Therefore, we use anti-LOX to moderate the tunica albuginea remodeling and observe penile lengthen. In the meantime, we evaluate it effects on erectile function.

Methods This study was performed on two phases of rats: puberty and adulthood, and intervened for 7 weeks. Puberty protocol included groups of control, anti-LOX (β-aminopropionitrile), −200 mmHg vacuum aspiration (VA), −200 mmHg VA + anti-LOX, −300 mmHg VA, and −300 mmHg VA + anti-LOX; adulthood protocol comprised groups of control, anti-LOX, −300 mmHg VA, and −300mmHg VA + anti-LOX. Penile length was measured by a modified VA device and verified by stretched status. Intracavernous pressure (ICP) and maximum ICP/mean arterial pressure ratio were recorded to assess erectile function. Western bolt and histopathological staining were performed to reveal LOX activity, and transmission electron microscope was performed to reveal the microstructural changes. The concentrations of pyridinoline, desmosine, hydroxyproline and elastin were also analyzed.

Results In puberty groups, anti-LOX significantly increased penile length by 10.79% than control rats; the lengthening effect was more prominent in −300 mmHg VA + anti-LOX group, which is 19.84% longer. In adulthood groups, even less effective, −300 mmHg VA + anti-LOX significantly lengthened penis by 17.35%, no penile retraction observed one week later, while stretched penile length was also significantly longer (14.35%). Anti-LOX inhibited LOX activity to reduce pyridinoline level, which led penile tunica albuginea remolding. Finally, anti-LOX had no impact on erectile function, whether combined with VA or not.

Conclusions Penile length is significantly increased by anti-LOX, which inhibited pyridinoline to induce tunica albuginea remolding in puberty and adulthood rats, and all rats have on erectile dysfunction."

These guys apparently gave rats BAPN and put home-made vacuum devices on their dicks and got a significan’t increase in penile length compared to controls.

Thoughts? I feel if you keep the does moderate you can stay in a "safe" level. You can really dive deep with the toxic effects relating to collagen biochemistry, but there are companies out there developing LOX inhibitors for cancer and fibrotic diseases, specifically targeted inhibitors against LOXL2.

I would sign up as a Guinea pig.

Well, I have NO idea how one would dose BAPN, but there are pea’s that contain it, so perhaps including those in your diet once or twice a week might give some effect. Maybe try contacting the authors of that abstract or do a little digging on pubmed, I haven’t done too much but there’s a few studies where they gave mice and rats the compound. In a few years there will be LOXL2 inhibitors on the market for the treatment of fibrotic diseases, see Simtuzimab that failed stage 2 clinical trials, not because of safety but lack of efficacy.

Wouldn’t this also make you more prone to injury? Cross-linking strengthens the collagen fibers. So while it would make it much easier to increase the size of a penis, it would also make it much more vulnerable to injury and damage. Even simply having an erection could conceivably cause problems.

This strikes me as a complete waste of time. You don’t need this to increase the size of your penis. Healthy diet and do the exercise routine. You’ll get your gains.

Though interesting, it looks like the unprocessed peas are toxic to humans and have been banned for consumption in countries that grow them. https://en.wiki pedia.org/wiki/ … athyrus_sativus

The part you missed about bapn is its irreversible.

It was given internally and it knocks out LOX permanently. Like draculas_son said. It weakens all collagen and ends up causing more harm than good. Also, studies have shown that topical application does zero for men with Peyronie’s disease. A sub *might* be GHK. It also does remodeling and can be applied topically and it seems to have few if any side effects.

But if you’re gung ho on bapn it is widely available online, orally active and cheap. GHK-Cu is cheap, active via subq injection and with dmso can be applied directly to the penis.

I just read that otc minoxidil or rogaine has antilox effects. Google it. Apply that topically and it’s a vasodilator so good for erections. Win-win

Wouldn’t that lead to unwanted hair growth on the shaft? I assume minoxidil only works on existing follicles, but still—some guys have more hair follicles on the shaft already as it is and presumably would not want to stimulate them.