tissue death
I would assume that tissue death is like running low on air for your brain. Even if you survive you get really messed up for life. Signs for this would be the ones like discoloration, coldness due to no circulation, shit like that. A dead part of the body is just that, DEAD. I don’t think it is coming back, so they cut it out before it festers and diseases the rest of the organism. So perhaps we are looking at amputation like in a diabetic for his foot that can’t be saved. In general most people cut it close and wander very close but not to tissue death. Just don’t be the unlucky one.
“You see, I don’t want to do good things, I want to do great things.” ~Alexander Joseph Luthor
I know Lewd Ferrigno personally.