Originally posted by Jones8315
DHT does everything testosterone can do-except turn into estrogen.
Sorry, I’ve been busy without the proper time to really look at this thread, but some of the mis-information on here is unreal.
DHT and Testosterone are almost completely different in action.
Dihydrotestosterone (DHT) is considered androgenic relative to testosterone since it is essential for the virilization of the external genital organs. On the other hand, DHT is not considered anabolic because it is not active in skeletal muscle (it is enzymatically deactivated); testosterone is anabolic in this regard, being responsible (along with other hormones and growth factors) for the development and maintenance of skeletal muscle.
Dihydrotestosterone binds the androgen receptor much more strongly than does testosterone at the same concentration, yielding a higher degree of ligand-receptor stability. When the concentration of testosterone is increased however, the receptor stability increases to a level similar to that seen with dihydrotestosterone (1). This has led to the proposal that the weaker androgenic potency of testosterone compared to that of dihydrotestosterone in target tissues such as the prostate resides in testosterone’s weaker interaction with the androgen receptor. Yet it is well known that some steroids which are very potent anabolic agents, such as stanozolol or oxymetholone, bind the AR only very weakly (2).
(1) Grino PB, Griffin JE, Wilson JD Endocrinology 1990 Feb;126(2):1165-72
(2) Saartok T, Dahlberg E, Gustafsson JA Endocrinology 1984 Jun;114(6):2100-6