Generic Cialis vs Generic Viagra

I’ve gotten headaches from both liquid C & V— apparenlty a not uncommon side effect— did you not get wood?

For me cialis is unpredictable - may work in 45 mins, or may work in 4 hrs. Actually seems to work best 10hrs later.

My urologist told me he does not like to prescribe it because of that. As opposed to Viagra or Levitra. Take it, 45 mins later BOOM!

Is Levitra also longer acting?

Do they all function in the exact same way?

I concur in re C peaking later rather than earlier— fortunately since I’ve past the age of just happening on a sexual situation instead of planning on one, I simply dose in anticipation— once I invest the C, I now have a reason not to surrender to my dysthmia and hide out from the world.

I can see why they are marketing the concept of “Cialis Daily”.

I can’t remember enough about the Levitra it was a long time ago. I think it was similar to the viagra, good for 4-ish hours?

Science guy what source are you using for your generic cialis? I agree with you that cialis gives me less side effects and seems to work for several days. It is weird but it does seem to work best about 8 to 36 hours after taking it so you have to time it right but its great for an awesome weekend.

I only buy actual cialis but its like 25 a pill! I’ve tried generic viagra from one of the reputable sources in the webslave thread. Also the actual viagra (but from some Pacific island) seemed to work but the generic silagra or whatever seemed to work great for giving me a stuffy nose and weird head rush like I drank 5 redbulls. I couldn’t even concentrate to have sex.

Maybe I should compare actual viagra to actual cialis before I judge though.

I posted this on a different thread where we got to talking about the $$$ involved in PE, including C and V.

Viagra:
How it works: It is a phosphodiesterase-5 enzyme inhibitor that results in release of nitric oxide and as a result, leads to smooth muscle dilation and inflow of blood into the corpus cavernosum during sexual stimulation. It has no effect in the absence of sexual stimulation and does not directly cause penile erections.
Onset of action: 30-60mins
Duration: 2-4hrs
No generic in US

Cialis (AKA “the weekend pill”):
How it works: Same as viagra
Onset of action: 1hr
Duration: 36hrs
No generic in US

Notes:
-Common side effects with both: headache and flushing
-Serious (rare) side effects: vision loss/vision changes and erection lasting more than 4 hrs (seek medical attention ASAP)
-SHOULD NOT BE USED with nitrates (for chest pain) —> lead to severe drop in blood pressure
-Cialis has a long duration of action but may not always be good because you may experience unwanted erection at unwanted time..
-Viagra is faster acting vs. Cialis but has short duration
-Should always take them about 1 hr before activity

Yes. Although the active drug is slightly different in each product, they all target phosphodiesterase enzymes as provided by archcore above. The trick is that there are different kinds of phosphodiesterase enzymes that work in different parts of the body. For example, there’s a slightly different phosphodiesterase in our noses that causes our nasal passages to constrict (leads to congestion, but the constriction is useful physiologically). There are others with various functions as well. Each member of this family of phosphodiesterase enzymes is indeed unique, but they look very similar to each other structurally. So a drug that binds to one to block it will bind to the others and block them as well. Thus, in brief, is the explanation for most side effects of most drugs.

The phosphodiesterase-5 that controls erections normally functions to inhibit the erection. When it is naturally blocked and the right combination of physiological signals are present (ie you are horny), the blood vessels change shape to allow blood to fill the penis without letting it leave, causing an erection. Targeting this enzyme with a drug takes the place of the natural targeting that causes an erection.

Tadalafil, the active drug in Cialis, happens to have a structure that binds more specifically to the phosphodiesterase-5 that controls erections than do the other ED drugs. It also binds more tightly. Higher specificity PLUS higher affinity. This means it targets the other forms of phosphodiesterase less, and sticks to the erection phosphodiesterase more. Nothing is perfect, and it still also can target the other enzymes, which is why many men here are being honest when they say Cialis has side effects for them.

So in terms of the ability of each drug to specifically target the enzyme controlling erections:

Viagra is least specific - lasts only a few hours
Levitra is more specific - lasts something like 10 hours
Cialis is most specific - lasts something like 36 hours

I speculate that the amount of time it takes to see effects of the drugs has to do with the dosage. Viagra pills contain something like 10x the dosage that cialis or levitra pills do.

Yeah that doesn’t explain why Levitra would be faster. But I read and write enough science all day at work so I don’t feel like figuring that out right now.

I don’t believe it has to do with dose with regards to the amount of time it takes to see effects. Viagra has a large dose compare to the others because it’s the property of the medication. For ED, viagra is given 50mg daily 1 hr before activity while levitra and cialis is given 10mg daily because that is the amount it takes to provide the desire effects. I would believe they are equivalent doses.

Onset of action depends on several factors such as the amount absorbed into the bloodstream from the GI tract, the metabolism of the drugs and how quick it occurs, how quickly the therapeutic drug concentration is obtained in the bloodstream, how fast the drug is being excreted from the body. Studies have shown that levitra and viagra both have an onset of about 30mins-1 hr. However, all three medications are recommended to be given 1 hr before sexual activities.

I have used both recreationally and although Viagra has given me one of those diamond cutting erections that was once off.
However on the other hand Cialis just seems to work better for me, I hang low and the fact that I have to take it only once
for the weekend is a plus.

I have had headaches from both and thus adjust my dosage.

I have toyed around with Cialis before and taken a super dose by mistake and let me tell you about having a near enough permanent
erection for 3days. Shit it was something else. Perhaps if I was a carnival orgy which was bound to last for days then sure enough I
would have been on it. One thing I noted was trouble sleeping and an increase in body temperature. I do remember some muscle fatigue
and lower back pain. However I do not recall it being a pleasant experience all I wanted to do was flush that shit out my system. Cialis
works very well at normal dosage and I actually think super doses are not effective.

Cialis for me gave awful body aches to the point I had to live on Motrin just to be able to sleep and the aches lasted for two days, it worked OK for me though but the sides were too much. Viagra is the best the sides are manageable and it’s out of your system faster and works the best for me, the jelly works the fastest. Levitra sucked but in all fairness the ones I got online might have been weak so I’m still undecided on these.

Viagra gel?

Do tell.

It’s by Kamagra and it hits hard and fast and then seems to get out of your system fast. Since it’s a jelly it seems to start working in 20 minutes. It’s my favorite because it works well and less sides.