Originally Posted by Bruna
I’m not sure if you guys are saying PRP is baseless but it is actually legit. I’m not sure how it would apply to PE but for other things like knee/elbow/ankle injuries it is the next best thing to surgery. And when used as a preventative or for joint strengthening it is as good as it gets.Sometimes a mixture of the blood platelets and colostrum is used. Others use just a saline solution to somehow cause a reaction that leads to tissue repair.
Baseless, not. As already showed, basic research on animals lead to think that could be useful in some cases. But at the next level, promises have been betrayed. Sham solution or saline solution showed as effective than PRP - sometimes better, actually. At the present, PRP therapy is like any other quack therapy you can find out there (magnets, ipnosis, drinking urine, meditation….), for which some people swear it is effective because, simply said, people can believe anything will work and if they believe, at some degreee it will work.
References were given earlier in this very same thread; some more:
"Expert Opin Biol Ther. 2011 Apr;11(4):509-18. Epub 2011 Feb 1.
Platelet rich plasma therapies for sports muscle injuries: any evidence behind clinical practice?
Andia I, Sánchez M, Maffulli N.
….
No PRP formulation has yet displayed proven solid evidence for the stimulation of healing and recovery after sports muscle injuries"
Platelet rich plasma therapies for sports muscle injuries: any evidence behind clinical practice?
"Clin J Sport Med. 2011 Jan;21(1):37-45.
Platelet-rich plasma treatment for ligament and tendon injuries.
Paoloni J, De Vos RJ, Hamilton B, Murrell GA, Orchard J.
….few randomized controlled clinical trials have assessed the efficacy of PRP injections and none have demonstrated scientific evidence of efficacy. "
Platelet-rich plasma treatment for ligament and tendon injuries
"Br Med Bull. 2010;95:63-77. Epub 2010 Mar 2.
Autologous growth factor injections in chronic tendinopathy: a systematic review.
de Vos RJ, van Veldhoven PL, Moen MH, Weir A, Tol JL, Maffulli N.
…….
only three studies using autologous whole blood had a high methodological quality assessment, and none of them showed any benefit of an autologous growth factor injection when compared with a control group. At present, there is strong evidence that the use of injections with autologous whole blood should not be recommended.
…"
Autologous growth factor injections in chronic tendinopathy: a systematic review
"Rev Med Suisse. 2011 Aug 10;7(304):1533-7.
[Treatment of tendinopathies: role for autologous platelet-rich plasma injections].
[Article in French]
Ziltener JL, Allet L, Grosclaude M.
Source
Unité de médecine physique et rééducation orthopédique, Service d’orthopédie et traumatologie de I’appareil moteur, Geneve 14. jean-luc.ziltener@hcuge.ch
Abstract
……..
The use of autologous blood injections for the management of chronic human tendinopathies can currently not be recommended."
[Treatment of tendinopathies: role for autologous platelet-rich plasma injections]
"Am J Sports Med. 2011 Aug;39(8):1623-9. Epub 2011 May 21.
One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trial.
de Jonge S, de Vos RJ, Weir A, van Schie HT, Bierma-Zeinstra SM, Verhaar JA, Weinans H, Tol JL.
Source
….
This randomized controlled trial showed no clinical and ultrasonographic superiority of platelet-rich plasma injection over a placebo injection in chronic Achilles tendinopathy at 1 year combined with an eccentric training program."
One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: a double-blind randomized placebo-controlled trial
"Br J Sports Med. 2011 Sep;45(12):966-71. Epub 2011 Mar 15.
Growth factor-based therapies ………
Elbow tendinopathy patients who had failed conservative physical therapy were divided into two patient groups: PRP injection (N=80) and autologous blood injection (ABI) (N=70). Each patient received two injections at 0 and 1 month. Patient-related tennis elbow evaluation (PRTEE) was recorded by a blinded investigator at 0, 1, 3 and 6 months. The main outcome measure was PRTEE, a validated composite outcome for pain, activities of daily living and physical function, utilising a 0-100 scale.
RESULTS:
At 6 months the authors observed a 66% success rate in the PRP group versus 72% in the ABI group, p=NS. There was a higher rate of conversion to surgery in the ABI group (20%) versus the PRP group (10%).
…."
Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections
"Br J Sports Med. 2011 Apr;45(5):387-92. Epub 2010 Nov 3.
No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy.
de Vos RJ, Weir A, Tol JL, Verhaar JA, Weinans H, van Schie HT.
No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy
Use of a ‘preventative or for joint strenghtening’ that is really baseless, by what I know.