I’ve recently been thinking about how, from what I’ve seen based on various postings, it can be complicated getting the proper amount of erect time. That led me to researching whether any popular vasodialators work in combination with the compounds at hand to provide any particular benefit, while also increasing erect time. I’m not too deep into said research, but I’m just trying to connect any dots I can. Most of this I’ve seen posted before in various spots, but figured I’d post my findings.
DHT and NO/Viagra-like compounds:
Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat
"These results show that DHT is the active androgen in the prevention of erectile failure seen in castrated rats, and suggest that this effect may be mediated, at least partially, by changes in nitric oxide synthase levels in the penis."
Papaverine increases cyclic AMP, synergises with PGE2.
Papaverine combined with prostaglandin E2 synergistically induces neuron-like morphological changes and decrease of malignancy in human prostatic cancer LNCaP cells
-"Papaverine combined with prostaglandin E2 synergistically induces neuron-like morphological changes and decrease of malignancy in human prostatic cancer LNCaP cells."
L-Arginine and Relaxin:
Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture
-"This study suggests that RLX is an endogenous agent capable of regulating vascular tone by activation of the L-arginine-NO pathway in vascular smooth muscle cells."
L-Arginine and IGF:
[Effects of L-arginine on the expression of insulin-like growth factors and insulin-like growth factor binding protein 3 in rats with intrauterine growth retardation]
-"L-arginine can increase the levels of IGF-I and IGF-II and the IGF-I mRNA expression in the brain of rats with IUGR"
L-Arginine, Vardenafil, VEGF:
Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3’,5’-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells
-"CCSMCs express eNOS and synthesize NO. NO synthesis leads to enhancement of VEGF synthesis via the NO/cGMP pathway. Combined L-arg and vardenafil treatment, which can enhance VEGF production."
L-Arginine, NO, VEGF:
Nitric oxide induces vascular endothelial growth factor expression in the rat placenta in vivo and in vitro
"Our data indicate that NO induce VEGF expression in vivo and in vitro in the rat placenta, suggesting that peaked NO production was maintained by a reciprocal relationship between NO and VEGF via HIF-1α."
L-Arginine and VEGF, Angiogenesis after exercise:
L-arginine supplementation causes additional effects on exercise-induced angiogenesis and VEGF expression in the heart and hind-leg muscles of middle-aged rats
"The present results suggest that in middle-aged rats, L-arginine administration caused additional effects on exercise-induced angiogenesis by presumably promoting VEGF expression"
Vardenafil, Angiogenesis/ischemia, VEGF, etc:
A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway
"Vardenafil .. Augmented capillary collateral formation in ischemic muscle. Vardenafil upregulated protein expression of vascular endothelial growth factor and hypoxia-inducible factor (HIF)-1 alpha in ischemic muscle and enhanced mobilization of Sca-1/Flk-1-positive endothelial progenitor cells (EPCs) in peripheral blood and bone marrow, contributing to neovascularization. Vardenafil also promoted capillary-like tube formation of human umbilical vein endothelial cells" .. "PDE5 inhibition enhances ischemia-induced angiogenesis .. Through a protein kinase G-dependent HIF-1/vascular endothelial growth factor pathway"
