The Chemical PE Thread

I have never used Caverject, but I remember some other chemical PE practitioners in the old days ("first wave of chemical PE") doing just that.
Decay within a matter of a few days (let’s say up to 3) should be minimal.

A short research didn’t yield any decay curves for stabilized PGE-1 in aqueous solution.

I have however found the official guide of Caverject, which is worth the read:
http://dailymed .nlm.nih.gov/da … 2d-a552bf594c98

It says:

I did find that quote from caverject guide, but they specified "not refrigerated or frozen". Do you think they mentioned this because refrigerating could damage the reconstituted form ?

Answering my own question(maybe others are interested too , so I will post it) :

http://www.topi x.com/forum/hea … OAL5E5S4V1LEL4G

""The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly.

Reconstitution and storage:

Only the supplied diluent should be used to prepare solutions.

Reconstituted solutions are physically and chemically stable for a period of 24 hours at room temperature and for 7 days in the fridge if stored in the original container. Do not store the unused pack or reconstituted solution in a freezer.""

Frequency of injection is a matter of side-effects. That’s at least what I get from the official recommendation. Prostaglandin can build up in your body - I write “Prostaglandin” because PGE-1 decomposes to other forms of prostaglandin.

Storage is another issue: Caverject is lypholized PGE-1 which behaves differently to untreated PGE-1. What I write when I refer to PGE-1 / Alpostradil (in particular when it comes to storage) is deduced from the producer’s data sheet.

Those patent patients are quite hard core as they swallow ointments (lol)

Penis enlargement - Adams, Kenneth W.

"The potentiator dihydrotestosterone 5% ointment was administered orally starting two weeks "

As far as I know, DHT is not orally active. I have no idea what they’re trying to say.

Has anyone tried adding PDE 4 inhibitors to their injections?

Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4)

I’m sure they meant to:use dht gel topically .

I thought about adding a pde 5 inhibitor like cialis to the mix (I think stagestop was doing it) to keep the penis in a pumped state even on non PGE 1 days. On other forums there are some guys who use viagra/levitra before injecting so they can use lower dose of pge 1.

Great thread doubleweener, and I dig the guide. I saw this thread posted on OMG’s PGE1 thread in professional muscle and really excited to see that there is more research going into this. There are a bunch of us over there that have gained a lot from chempe.

I just wanted to throw some of what I’ve found and my opinions into the mix to further the thread.

When I first started injecting I had a lot of trouble even reaching an erection with pge1. Since others have had it easier I assumed it was my hormonal makeup, and started tweaking it to get better errections and be more sensitive to pge1. I also had a small injury to my dick due to over eager/excited jelqing, and pge1 and prolonged erections has actually helped heal that.

I’ve tried:
Adding herbs/chemicals that decrease the breakdown of PDE5 (Horny Goat weed, pomegranate, Sildenafil, vardenafil) - Helps some but not enough to be worth it.
Herbs and chemicals that increase dht (creatine, eucommia bark) - Somewhat helpful
Topical DHT - Does help and seems to support growth in cycles
Increasing dosage - I don’t think it’s necessary
Different schedules (1 day one, 1 day off; 2 days on 1 day off; etc)

My findings and opinions:
The method I’ve settled on is 5-6 days of injection, 1 day off. I seem to get the most growth when I do longer stints of injecting without a day to rest.
I also inject 30 mcg right before bed and take 1 paba and usually have a 4-7 hour erection. I have been at this dose for the past 4 months, injecting for 5-6 days straight.

Herbs that increase sensitivity to pge1:
Forskolin - Makes cells more sensitive to pge1 - and based on this, anything that increases cAMP may increase sensitivity to pge1.
Paba - Slows the breakdown of pge1

I think that the fear of priapisms is what halts many guys progress. But the priapisms along with pge1 is what seems to cause the growth. That pge1 causes high flow priapisms, which if controlled I think are completely fine. It’s low flow priapisms that are problems, where you have necrosis.
If you need to kill your erection you can down some sudafed and jump in cold shower and you’ll be good.

I also suspect that regardless of whether you get an erection or not pge1 causes growth in girth.

In 4 months my growth has been .5 inch in length and a 1 inch in girth.
I’m going to be manually stretching more, and agree that chempe seems to hit girth gains easily, but you have to stretch for length. And going to be looking into this other research.

Best of luck to everybody in their growth.

Also wanted to add, I did some reloxifene to get rid of some gyno, and found that I responded better to pge1 and grew more. I think due to the increase in gonadotropins.

Same with pramipexole, which I think is because of the increase in -1.

Hey Icedcool, congratulations on your gains and thanks for the suggestions .

You said
“But the priapisms along with pge1 is what seems to cause the growth” after which you said “regardless of whether you get an erection or not pge1 causes growth in girth.” . So what’s it gonna be? :)

I used andractim gel along with some irregular schedule of hanging. After about 30 days I stopped using it as it caused a loss of libido(I think that by lowering the estrogen levels too much) so I didn’t measure to see if there were some gains as I was eager to restore my libido back and stop using dht.

What do you think about using clomid instead of reloxifene ? Every time I use it(rarely) in short cycles(3-5 days) it increases my libido/ejaculate volume

Thanks for your input, Icedcool!

I am very surprised about your experiments with Reloxifene , which is prescribed to women mainly for breast cancer, and Pramipexole , also used for the treatment of Parkinson’s disease. Here’s a quick summary:

Selective Estrogen Receptor Modulators (SERMs)

From: (emphasised the bits I found interesting for PE)
I recommend reading the full text in original to see all the hyperlinks for further information.

Apart from that, I am fully with you about injecting PGE-1 several days in a row. If soreness takes over, VEGF can alleviate some of it and at the same time spur smooth muscle angiogenesis. I also inject late in the evening after a heavy clamping session for erections that can last the entire night.

I think they both do. I know priapism does as shown by cases of megalophalus. I’ve experienced girth growth and aching with pge1 without a long term erection as well.. I suspect that the sorness is the growth happening.
I think there is some research that backs up the delinking of the tunica with pge1?
All this is opinion and under discovery though.

I was using raloxifene to help me get rid of some puberty gyno, and it also supports the hypothalamic pituitary gonadal axis getting back to normal.. Aka balancing out your hormones. Supposedly not as much as tamoxifen though.
Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia

Pramipexole I was using more for fun as it decreases prolactin and is a dopamine agonist. Side effect for me was it helped decrease gyno further, increases igf1 and I had more and fuller erections and it seemed to support growth. Which lends more support to that igf1 can help with penis growth with pge1. I think there is more to this around how dopamine increases erections as well.

Clomid could be used the same as how raloxifene was supporting my growth. So yea more gonadotropins.. Just without the gyno reduction :) .

I was surprised as well that they supported. But I think it points to that having more testosterone and dht support growth while we are injecting pge1, and how igf1 can support growth.

Slow injection of prostaglandin E1 decreases associated penile pain

Slow injection of prostaglandin E1 decreases associated penile pain.

Found a thread on another board with a very recent account of someone using the Dr. Adams protocol with gains. Confirms the use of a Verapamil 20%, DMSO 10% cream, as well as an unlabeled, multiple vasodialator injectable. The poster is also using some growth factors, independent of the Dr, of course. Just figured it was worth mentioning. Always encouraging to see more reports of what we’re trying to do working. Thread can be viewed here: HONZEE’s CHEM PE and PMMA Log/journal/archive - PhalloBoards (Version 2.0)

Just would like to remember that high flow priapism does not cause growth for most of people. There are thousands if not million of men who suffered of prolonged priapism, only a handful of them get an enlarged dick from it. An enlarged but no always working dick actually, since priapism can cause fibrosis in smooth muscle.