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Incorporating a Lox Inhibitor Into PE


START 18/13.15 cm Jul 24th 18 (7.09/5.18") NOW 22.5/15.2 cm Fer 12th 20 (8.86/5.98") GOAL 8.5"/ 6"

When connective tissue is stretched within therapeutic temperatures ranging 102 to 110 F (38.9- 43.3 C), the amount of structural weakening produced by a given amount of tissue elongation varies inversely with the temperature. This is apparently related to the progressive increase in the viscous flow properties of the collagenous tissue when it is heated. (Warren et al (1971,1976)

Huh. Link doesn’t work for me either. Just Google β-aminopropionitrile (BAPN) fumarate. Title of the article is “β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice”


Starting: (3/1/20) BPFSL 6.75" NBPEL 6.5" MSEG 4.9"

Now: BPFSL 7.5" NBPEL 7.0" MSEG 5.0"

Goal 8" NBPEL 6" MSEG

Originally Posted by ronjon
Huh. Link doesn’t work for me either. Just Google β-aminopropionitrile (BAPN) fumarate. Title of the article is "β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice"

Interesting. That does not appear to be the same substance on the supplement market. I would use this
5-LOX Inhibitor with AprèsFlex®, 100 mg, 60 vegetarian capsules - Life Extension

Thanks for pointing that out, though.

Originally Posted by Kyrpa
From the discussion section of the referred study .
"Most importantly, anti-LOX with BAPN has been employed to induce thoracic aortic dissection in rodent models, and systemic effects after intragastric administration of BAPN could not be ruled out in the current study."
Please, read more about the hazardous potential of the pills you are going to swallow like there is no tomorrow.
Also, make sure no one in your family, close or distant has not died on an aortic aneurysm. If you have the potential familial disease possibility, you can start betting how you are leaving too with this substance.

Remus EW, O’Donnell RE Jr, Rafferty K, Weiss D, Joseph G, et al. The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms. Am J Physiol Heart Circ Physiol 2012; 303: H1067–75.

Bruel A, Ortoft G, Oxlund H. Inhibition of cross-links in collagen is associated with reduced stiffness of the aorta in young rats. Atherosclerosis 1998; 140: 135–45.

Maki JM. Inactivation of the lysyl oxidase gene lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation 2002; 106: 2503–9

These are for a start.

That’s definitely not the lox inhibitor I was considering.

Here is what I am looking at. I appreciate the words of caution.

5-LOX Inhibitor with AprèsFlex®, 100 mg, 60 vegetarian capsules - Life Extension

Originally Posted by Eormensyll
That’s definitely not the lox inhibitor I was considering.

Here is what I am looking at. I appreciate the words of caution.

5-LOX Inhibitor with AprèsFlex®, 100 mg, 60 vegetarian capsules - Life Extension

This is definitely not the Lox inhibitor either you referred to in your initial post, with the rat’s penises elongating.

Therefore don´t wait much for a penis enlargement while on the substance.


START 18/13.15 cm Jul 24th 18 (7.09/5.18") NOW 22.5/15.2 cm Fer 12th 20 (8.86/5.98") GOAL 8.5"/ 6"

When connective tissue is stretched within therapeutic temperatures ranging 102 to 110 F (38.9- 43.3 C), the amount of structural weakening produced by a given amount of tissue elongation varies inversely with the temperature. This is apparently related to the progressive increase in the viscous flow properties of the collagenous tissue when it is heated. (Warren et al (1971,1976)

Originally Posted by Kyrpa
This is definitely not the Lox inhibitor either you referred to in your initial post, with the rat’s penises elongating.

Therefore don´t wait much for a penis enlargement while on the substance.

I mentioned the study because it got me thinking whether or not the mechanisms at work with regards to Lox inhibitors would be in any way beneficial to PE. It seems it’s action as a potent anti inflammatory, as well as its purported benefits to arterial health, would prove useful to PE.

The linked supplement is what I found available for safe human consumption.

Originally Posted by Eormensyll
I mentioned the study because it got me thinking whether or not the mechanisms at work with regards to Lox inhibitors would be in any way beneficial to PE. It seems it’s action as a potent anti inflammatory, as well as its purported benefits to arterial health, would prove useful to PE.

The linked supplement is what I found available for safe human consumption.

That should be safe. But surely is not anything like the substance used in the study linked. Even the claimed mechanism of action is very different.


START 18/13.15 cm Jul 24th 18 (7.09/5.18") NOW 22.5/15.2 cm Fer 12th 20 (8.86/5.98") GOAL 8.5"/ 6"

When connective tissue is stretched within therapeutic temperatures ranging 102 to 110 F (38.9- 43.3 C), the amount of structural weakening produced by a given amount of tissue elongation varies inversely with the temperature. This is apparently related to the progressive increase in the viscous flow properties of the collagenous tissue when it is heated. (Warren et al (1971,1976)

The real anti-LOX of the study is available at around 50 dollars per 1 microgram, a few labs produce and sell it, and I believe all of it is hypoxia induced anti-lox. There is no dosage mentioned for rats though, so you might be fine with 50 micrograms, or you might need like half a kilo. So there’s that too.


inicial 1996: BPEL 15cm (Margin of error +/- 0.5cm) MSEG: 14.1 cm

inicio extender (sept2012): 15,5cm BPEL /14,1cm MSEG --- Hanging: inicio: Ago 21 2022 21.0cm --- Ultima medicion: Sept 1 2022: 21.6cm BPEL x 15,1cm MSEG

Meta: 28cm BPEL x 21cm MSEG -- si, quiero tenerla mas gorda que tu vieja. jaja

Originally Posted by redmorsilla
The real anti-LOX of the study is available at around 50 dollars per 1 microgram, a few labs produce and sell it, and I believe all of it is hypoxia induced anti-lox. There is no dosage mentioned for rats though, so you might be fine with 50 micrograms, or you might need like half a kilo. So there’s that too.

They were using 100 mg/ kg indeed. For seven weeks on a daily basis. The human equivalent for rat dose can be calculated by multiplying the dose by 0.162


START 18/13.15 cm Jul 24th 18 (7.09/5.18") NOW 22.5/15.2 cm Fer 12th 20 (8.86/5.98") GOAL 8.5"/ 6"

When connective tissue is stretched within therapeutic temperatures ranging 102 to 110 F (38.9- 43.3 C), the amount of structural weakening produced by a given amount of tissue elongation varies inversely with the temperature. This is apparently related to the progressive increase in the viscous flow properties of the collagenous tissue when it is heated. (Warren et al (1971,1976)

Ok the Anti Lysyl Oxidase, as I stated before but missed one zero on the price, is at an affordable 500 dollars per milligram. I just now realized I wrote 50. Well, it’s 500 dollars. Sorry for the mistake. That is the compound used in the experiment. It was given everyday and they say it was given orally. Though they never mention what amount.
Anyways, Even though it promises great growth, there are a few things you must consider: they didn’t give a darn shit about side effects and they killed the rats as soon as the experiment ended so we don’t know the long term effects either. Just 1 week decon is not enough to “lose it all” the gains. If it were 3 months or more, then we might get a totally different outcome. And might not be permanent.

However:
There is valuable information on the experiment files. Notice they do mention better growth at -300mmHG than at -200mmHG (that’s somewhere around 10,5hg and 7-8Hg respectively), and that they used twice a day 2 sets of 5 minutes of high vacuum exposure. So that’s a total of 20 pumping minutes per day, very achievable, although at high pressure which will cause discomfort (rats were anesthetized, remember that) and there are mentions of bleeding. But the results for just VD were at 8% tunica growth in just 8 weeks.
I have started a thread in the spanish forum with my experience from this routine. Although I do not have a manometer yet so I’m not certain of the pressures used, I am using sensory memory to find the sweet spot, considering the amount of pull force created by such a vacuum in the tube. Anyways, in the first 15 days, I am going around 1 to 1,3 cm further in the tube. Last week had too many issues of privacy so I only could do 1 set per day and there is almost no difference between last week and today, but hopefully next week I’ll be more quiet and be able to do those 2 daily sessions. So again, from the gains seen on first 2 weeks (probably not permanent nor cemented yet) I think these guys from China might be on to something, even without the anti-lox.


inicial 1996: BPEL 15cm (Margin of error +/- 0.5cm) MSEG: 14.1 cm

inicio extender (sept2012): 15,5cm BPEL /14,1cm MSEG --- Hanging: inicio: Ago 21 2022 21.0cm --- Ultima medicion: Sept 1 2022: 21.6cm BPEL x 15,1cm MSEG

Meta: 28cm BPEL x 21cm MSEG -- si, quiero tenerla mas gorda que tu vieja. jaja

Originally Posted by redmorsilla
Although I do not have a manometer yet so I’m not certain of the pressures used, I am using sensory memory to find the sweet spot,

Try your local auto parts or farm supply store and tell them you want a vacuum gauge. Pick up a 1/4”/6mm tee fitting while you’re there. If your gauge has a 2 or 3mm hose you’ll need a stepped adapter up to 6mm.

Originally Posted by AndyJ
Try your local auto parts or farm supply store and tell them you want a vacuum gauge. Pick up a 1/4”/6mm tee fitting while you’re there. If your gauge has a 2 or 3mm hose you’ll need a stepped adapter up to 6mm.

I know, but I got only cash and bank account is on the red, and I’m pretty darn far from the closest “ferreteria” so I cannot order it online and cannot reach physically. But I will eventually (or get to the ATM to deposit).
The hardships of living in the middle of nowhere and working in another middle of nowhere hahaha

But thanks anyways man.


inicial 1996: BPEL 15cm (Margin of error +/- 0.5cm) MSEG: 14.1 cm

inicio extender (sept2012): 15,5cm BPEL /14,1cm MSEG --- Hanging: inicio: Ago 21 2022 21.0cm --- Ultima medicion: Sept 1 2022: 21.6cm BPEL x 15,1cm MSEG

Meta: 28cm BPEL x 21cm MSEG -- si, quiero tenerla mas gorda que tu vieja. jaja

Originally Posted by Kyrpa
They were using 100 mg/ kg indeed. For seven weeks on a daily basis. The human equivalent for rat dose can be calculated by multiplying the dose by 0.162

So whats the equivalent dosage for humans, I’m confused.

100mg/kg X 0.162 = 16.2 mg/ kg

So a 70 kg human would need (16mgX70kg) 106 mg per day for same effects? Can you please correct me if this is wrong?

Originally Posted by GoodGoneBad
So whats the equivalent dosage for humans, I’m confused.

100mg/kg X 0.162 = 16.2 mg/ kg

So a 70 kg human would need (16mgX70kg) 106 mg per day for same effects? Can you please correct me if this is wrong?

So it’s like 1000 dollars per dose, everyday, for 8 weeks. Assuming producers do sell to general public, which is far-fetched.


inicial 1996: BPEL 15cm (Margin of error +/- 0.5cm) MSEG: 14.1 cm

inicio extender (sept2012): 15,5cm BPEL /14,1cm MSEG --- Hanging: inicio: Ago 21 2022 21.0cm --- Ultima medicion: Sept 1 2022: 21.6cm BPEL x 15,1cm MSEG

Meta: 28cm BPEL x 21cm MSEG -- si, quiero tenerla mas gorda que tu vieja. jaja

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