Incorporating a Lox Inhibitor Into PE

Hello everyone: so this will be my first post on Thunder’s place.

I am curious to know if anyone has incorporated a Lox inhibitor into their PE routine? I have been reading a lot into the subject of PE in general, trying to get myself educated. Here is the paper where the information came from:

https://doi.org … /aja.aja_120_19

This is the quote that caught my eye:
“However, a study on rats released later did suggest that combining an enzyme called anti-lysyl oxidase (anti-LOX) with a vacuum device did increase penis length by almost 11%, and the combination of anti-LOX with the device was more successful than anti-LOX alone.”

I would love to hear if anyone has tried to use lox inhibitors in their PE routine.

I think I might try while doing the newbie routine, plus occasional pumping.

Thanks, and glad to be here.

I would stay away from any MAO inhibitors

This isn’t an MAOI. It’s function is to inhibit inflammatory leukotrienes.

Nope.

My mistake. However, I still wouldn’t bother taking such thing, despite its proven effect on rats.

It’s hard to determine how the compound was administered? The anti-LOX that is. I have read up a bit on this, and it is interesting, but how would one proposed it be used in PE?

Welcome to Thundersplace, Eormensyll. How would you go about incorporating this into your routine?

I’m thinking of using it on days that I pump and on recovery days. I would do it like I do with any other new supplement, try it exclusively for 30 days minimum (unless it causes me problems) and then evaluate my results.

I know gains need much more time than 30 days, that’s just the window I use for trying a new supplement.

I was really hoping that someone else might have used this supplement, or a similar inflammatory leukotriene inhibitor. I’m still learning, and looking for guidance.

There doesn’t seem to be a methods section in the study. I’m assuming this is injected?

I assume as a daily supplement or for recovery days or phases.

It is available (for humans) in capsule form. That’s the route I’m planning to take.

Here it is

Anti-LOX was performed by intragastric administration of a specific LOX inhibitor, β-aminopropionitrile (BAPN) fumarate (Shanghai Aladdin Biochemical Technology Co., Ltd., Shanghai, China), using a dose of 100 mg kg−1 day.

Yikes! -300 mmhg vaccum! “VD aspiration was stopped for 1 or 2 days when serious prepuce bleeding”. Yeah no shit.

I’ll pass on the risk of aortic dissection.
https://www.nature.com › articles › srep28149

From the discussion section of the referred study .
“Most importantly, anti-LOX with BAPN has been employed to induce thoracic aortic dissection in rodent models, and systemic effects after intragastric administration of BAPN could not be ruled out in the current study.”
Please, read more about the hazardous potential of the pills you are going to swallow like there is no tomorrow.
Also, make sure no one in your family, close or distant has not died on an aortic aneurysm. If you have the potential familial disease possibility, you can start betting how you are leaving too with this substance.

Remus EW, O’Donnell RE Jr, Rafferty K, Weiss D, Joseph G, et al. The role of lysyl oxidase family members in the stabilization of abdominal aortic aneurysms. Am J Physiol Heart Circ Physiol 2012; 303: H1067–75.

Bruel A, Ortoft G, Oxlund H. Inhibition of cross-links in collagen is associated with reduced stiffness of the aorta in young rats. Atherosclerosis 1998; 140: 135–45.

Maki JM. Inactivation of the lysyl oxidase gene lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice. Circulation 2002; 106: 2503–9

These are for a start.

Not seeing anything of the sort in that link. 5 lox inhibitor seems to be a safe and effective anti inflammatory.
Can you elaborate? Because I don’t want aortic dissection either.