Great stuff mravg. This thread is turning into a 400 level PE course. Thanks for this. You’re pointing directly towards what I was stumbling around, and with more biological knowledge I might add.
Your comparison to priapism is not valid because priapism results in ischemic tissue damage, again leading to the immune response and fibrosis.
Interstitial fluid, as we see after clamping or pumping, comes from capillary leakage. This fluid is non-cellular, as white cells or fibroblasts can not pass through the capillary wall. Without fibroblasts, there is no fibrosis. I do not think that the presence of this fluid by itself, for the time periods typical in PE, lead to an immune response.
This next part is an especially good bit which bears directly on vaseline_knights theory and whether not it could be true
If you theorize that this collagen formation occurs quickly, then I think you should be clear that this is only your theory. There may be data out there about the typical response times between the onset of edema, and subsequent bodily responses like Fibroblast proliferation, which is what you would need to help substantiate this theory.
However, regarding this-
I tend to agree with Wantsmore, that the lack of fibrosis problems reported by pumpers and clampers, is evidence to the contrary of your theory, albeit only anecdotal.
I think that the wild card here might be that the fibrosis could be a kind of low level, cumulative thing that eventually creates what we’ve come to see over time as a kind of PE “ceiling”- i.e. an outer limit for gains which might (if this long term fibroidal buildup were true) be caused by fibrotic, inflexible tissues which build up in the trans dermal area over prolonged periods of PE’ing. However, as you’ve said, this is all dependant on whether or not these fibrotic changes (however slight) are even happening at all so long as the PE that is being done is being done in the proper way.
Hmmmm….vaseline_knight? I hope we stick with this. Now the topic really appeals to me as a “ceiling for gains” is something that has always vexed me. Are gains beyond 2-2.5” commonly possible or is there really a limiting factor? Are people quitting because they are happy with their new dicks or because their gains have reached a point of limiting returns? Is this point of limited returns due to the fact that gains are REALLY hard to get for them now? And if so, what is causing the difficulty in achieving any new gains?
Hmmmm….