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Scientific evidence for PE!

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Scientific evidence for PE!

This study was mentioned before but I think some of the implications were ignored.

https://www.ncbi.nlm.nih.gov/pubmed/31736474

First, the study shows that simply using a pump can grow your penis at least 8% (study on rats).
Second, taking something called anti-lox can grow it by 10%. This happens because the anti-lox is softening/remodeling the tunica albuginea.
Combine the pumping and the anti-lox and you get 17.4%!
People are always looking for scientific evidence of PE and many experts say you can’t grow your penis.
I’m going to take a closer look at all the threads around softening the tunica.
I did some initial research into exactly what anti-lox is and it seems like something you want to be really careful with, messing with your collagen systemically with drugs can cause aneurisms and stuff.

Where could you purchase anti-lox?

Pumping rats dicks??????????????????????? LoooooooooooooooooooooooooooooooL

Can you imagine taking a Rat and pump his dick? And the pump will be so tiny! The picture kills me ! hahaha

What a terrible study. It doesn’t answer the most important questions: do the rats with big dicks get all of the female rats? What about girth? Are the male rats happy with their new size or do they keep going back for more antilox and a pump? Inquiring minds want to know.


Initial: 7” BPEL; 6” NBPEL; 5.25” - 5.5” MEG

Current: 7.5” BPEL; 7” NBPEL; 8.25” BPFSL; 6.25” - 6.5” MEG w/ c-ring.

Goal: Improved/consistent EQ while managing ED. Secondary: maintain current stats.

Originally Posted by 32quarters
What a terrible study. It doesn’t answer the most important questions: do the rats with big dicks get all of the female rats? What about girth? Are the male rats happy with their new size or do they keep going back for more antilox and a pump? Inquiring minds want to know.

I think rats suffer from body dysmorphia like us and still view themselves as small despite their gains. So i am sure that they keep going back for more and more pump.

Originally Posted by Gentlepsychopath

I think rats suffer from body dysmorphia like us and still view themselves as small despite their gains. So i am sure that they keep going back for more and more pump.

You’re likely right. They been watching too much big-dick rat porno, and now they don’t think they can really satisfy a she-rat.

I don’t believe LAPump offers a pump cylinder that small. At least their chart doesn’t go down that far. Also, Is there a brake bleeder that’ll work on such a cylinder. Perhaps a Mini Cooper os Smart Car brake bleeder.


Start 11/09 BPEL: 5.5", EG: 4.4"

Current. BPEL: 6:4", EG: 5.5"

Originally Posted by 32quarters
What a terrible study. It doesn’t answer the most important questions: do the rats with big dicks get all of the female rats? What about girth? Are the male rats happy with their new size or do they keep going back for more antilox and a pump? Inquiring minds want to know.


I actually read the whole study for the lols after seeing this post, and the poor rats didn’t get to enjoy their very impressive gains at all.

Sadly they all had their junk cut off at the end of the experiment. For science.

Originally Posted by raybbaby
You’re likely right. They been watching too much big-dick rat porno, and now they don’t think they can really satisfy a she-rat.

Well after doing PE they realize if they’re big now, then their girls all had even huger exes…and the experiment doesn’t cover how 100% of the rats got addicted to PE after.


Now: 9" BPEL x 6.25" MSEG as of 11/10/2019 This is my story, a few progress pics of me here, and all my methods.

Then: 6.25" x 4.37" in 8/2009 Are you new to PE? Here's some advice I wish someone had given me when I first started.

My Extender and forward to 10" and balls enhancement project. There is no "Holy Grail" of Penis Enlargement. Only time and effort works. I'm *10* years in and counting. All you have to do is put the work in and keep the faith.

Originally Posted by teodeles2
Pumping rats dicks?? LoooooooooooooooooooooooooooooooL
Can you imagine taking a Rat and pump his dick? And the pump will be so tiny! The picture kills me ! Hahaha

Hahahahahahah

I was thinking the same think, there must be a mr big ratty who got a big penis as long as his whiskers!


21/09/2019. 6.2 inches bone pressed erect length.

Short-term goal 24/12/2019

7inches bone pressed erect length

How Can We Use This Info

Like it says in the study, “These results suggest that anti-LOX elongates the penis by reducing pyridinoline, which induces tunica albuginea remodeling.”

So what does it mean. The Pyridinoline (cross-linking compound of collagen) cannot be synthesized because lysyl-oxidase (LOX), which is the catalyst of the process, is being destroyed by the antibody, anti-LOX. So..

Originally Posted by Lookinforgirth
Where could you purchase anti-lox?

Wherever antibodies are sold.. I found a price for $50 per 100 milligrams. If we use the same dose as the study, a 90 kg man would need 9 grams per day so $4,500 per day, maybe cheaper in bulk.

Also taking experimental antibodies can be very dangerous.

So if the drug is out of the question, how can we use this information to our advantage?

Originally Posted by Alex2.0
Like it says in the study, “These results suggest that anti-LOX elongates the penis by reducing pyridinoline, which induces tunica albuginea remodeling.”

So what does it mean. The Pyridinoline (cross-linking compound of collagen) cannot be synthesized because lysyl-oxidase (LOX), which is the catalyst of the process, is being destroyed by the antibody, anti-LOX. So..

Wherever antibodies are sold.. I found a price for $50 per 100 milligrams. If we use the same dose as the study, a 90 kg man would need 9 grams per day so $4,500 per day, maybe cheaper in bulk.

Also taking experimental antibodies can be very dangerous.

So if the drug is out of the question, how can we use this information to our advantage?

There is a rate conversion, rats to Humans, we cannot just convert body weight, sorry about my bad english..

Human Equivalent Dose

Originally Posted by ironmaiden_666
There is a rate conversion, rats to Humans, we cannot just convert body weight, sorry about my bad english..

This is from a scientific journal article titled, “A simple practice guide for dose conversion between animals and humans.” One way to calculate Human Equivalent Dose (HED) is:

HED (mg/kg)= [Animal NOAEL (mg/kg)] × [Weight animal (kg) / Weight human (kg)] ^ 0.33

NOAEL is the no observed adverse effects level.
The reference weights are in Table 1 in the study, here is a link:

https://www.ncbi.nlm.nih.gov/pmc/ar…port=objectonly

So if we assume that the 100 mg/kg is the NOAEL, the HED is then 13.8 mg/kg per day. The article says to add a factor of safety of 10, so its 1.38 mg/kg for the first human trials.

And the cost is $50 per 100 mg; then the price for a 90 kg man is $62.30 per day.

Is the antibody out of the question now? I’m still curious how to use this information.


Last edited by Alex2.0 : 12-04-2019 at .

Is there any reason to believe this drug targets the tunica? I would be concerned that effected ALL ligaments/tendons in the body, and I’m not excited to have all of those made more pliant. I pull enough muscles in the gym already. And I’ve had enough friends with Ehlers-Danlos syndrome who were always on the verge of pulling a muscle. The ones who have it more severely are aging particularly painfully. One needs to be fed through a tube because the disintegration of her collagen is hitting her digestive tract first. Another suffers pain literally every moment she talks or chews, because the smooth plate where her jawbone meets her skull wore away.

Apologies for pissing on the party here, but a drug that softens your body’s connective tissue and makes it more pliant sounds like it’s getting deliberately close to a controlled dose of “I should have Ehlers-Danlos syndrome for a few weeks so my dick can grow faster.” I don’t imagine that stepping into that state for a few weeks would have the same effect as living with the disease for 30+ years. You probably wouldn’t notice these effects. If I had to guess. But perhaps a bit of caution than our community normally shows is warranted towards this particular intervention. Most of the approaches we discuss are targeted. I don’t see any reason to believe this one is.

Originally Posted by deSol
Is there any reason to believe this drug targets the tunica? I would be concerned that effected ALL ligaments/tendons in the body, and I’m not excited to have all of those made more pliant. I pull enough muscles in the gym already. And I’ve had enough friends with Ehlers-Danlos syndrome who were always on the verge of pulling a muscle. The ones who have it more severely are aging particularly painfully. One needs to be fed through a tube because the disintegration of her collagen is hitting her digestive tract first. Another suffers pain literally every moment she talks or chews, because the smooth plate where her jawbone meets her skull wore away.

Apologies for pissing on the party here, but a drug that softens your body’s connective tissue and makes it more pliant sounds like it’s getting deliberately close to a controlled dose of “I should have Ehlers-Danlos syndrome for a few weeks so my dick can grow faster.” I don’t imagine that stepping into that state for a few weeks would have the same effect as living with the disease for 30+ years. You probably wouldn’t notice these effects. If I had to guess. But perhaps a bit of caution than our community normally shows is warranted towards this particular intervention. Most of the approaches we discuss are targeted. I don’t see any reason to believe this one is.

I am leery of chemicals. Tried them. Still leery.

I support the conclusions that pumping works. This experiment does validate the use of negative pressure on a penis. However, chemicals that have a global effect on the body need to be very carefully considered. And unless a localized injection were used I wouldn’t want to utilize the chemical.


Now: 9" BPEL x 6.25" MSEG as of 11/10/2019 This is my story, a few progress pics of me here, and all my methods.

Then: 6.25" x 4.37" in 8/2009 Are you new to PE? Here's some advice I wish someone had given me when I first started.

My Extender and forward to 10" and balls enhancement project. There is no "Holy Grail" of Penis Enlargement. Only time and effort works. I'm *10* years in and counting. All you have to do is put the work in and keep the faith.

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