“This is not a game, Jones. Your suggestion in a post at another site you frequent that guys who try this are “rats” demeans us all. “
avocet8
Stop playing games. I am a lab rat. I seem to recall a post in the main member forum titled, “lab rats”. I don’t remember anyone else saying they were demeaned, probably because I stated this was an experiment on day 1.
Southpaw
I am not surprised. Many doctors hold this antiquated notion that testosterone is the most important androgen. Androgen science has changed rapidly very recently. The truth is, testosterone is a pro-hormone. Its slight activity compares nothing to DHT.
“You pontificate as if there is no material difference between free base testosterone and DHT” I believe anyone who has read my posts would not understand your statement.
Southpaw, you claim to be a doctor, so I have a medical question for you. Let us say, the normal number of T molecules is 25, and the normal number of DHT molecules is 5. Let us prescribe scores to each molecule, so that we sum the body’s total amount of receptor activity. Knowing that DHT binds six times better then T, we give it a score of 6. T gets a score of 1. So our total androgen power ((25*1) + (5 *6 )) is 55.
Ok. Now lets use androgel and add 10 molecules of T. Leaving a 35:7 ratio of T to DHT (as you said before, southpaw, some T gets converted). So how many times do our androgen receptors get activated? ((35*1) + (7*6)) The answer is 77. Ok, so T replacement activates 77 receptors.
Ok, instead of using androgel, let us use a DHT cream. Let us use 1 DHT molecules. It represents 20 percent in our model. We are not applying anything nearly this concentrated to our penises though. Ok, the change in DHT is simply addition, because 5AR is a one way street. Intially, 25:5, now ((25*1)+((5+1)*6)) or 61.
What have we learned? Using testosterone gave us a score of 77, while a small amount of DHT gave us a score of 61. While my numbers are not exactly in direct ratio with the human body, this proves that small amounts of DHT act on the body in the same manner high doses of T can. DHT simply has a stigma, that is all. We know now that it is not the enemy. In Europe, DHT creams are used as ED treatments. Why? Because as I have illustrated, since T and DHT simply do the same thing at different rates, if you adjust the dose, similar results can be achieved.
But doesn’t DHT have a receptor somewhere in you body that triggers something bad? No. DHT does everything testosterone can do-except turn into estrogen.