The big penis and mens' sexual health source, increasing penis size around the world.
This is really interesting!
When you say fatigued from a 7 hour erection, how ones that feel? Are you constantly stimulating to maintain it or is it purely from the injections and just an irreversible hard on only to be lessened with the other injection ?
I had surgery once on my D and I remember the doctor injecting me with something that resulted in rock hard EQ to ensure his stitching was right. Must have been something similar
Hey, XL,I’m basing my chemical PE course on a program shared by a member called stagestop from many years ago. The basic idea is that the several hour-long intense erection in the corpora caverns (CC) from PGE-1-containing compounds (in my case Trimix) acts like internal clamping or ballooning, while it also may act to loosen collagen cross-linking at the tunica. Along with this, taking some supplements (both oral and topical) that might also create some collagen loosening (in my case PABA and topical DMSO) and doing a minimal amount of some kind of traction on the tunica every day (short duration manual stretches, some pumping and extender when possible) could result in permanent enlargement.
The Trimix (or whatever PGE-1 compound) is injected directly into the CC to create the erection. It is a long-used ED medication. So while injecting into the penis has some mental challenges, if good, clean technique is used and you know what you are doing, it’s not a big deal.
I’m also injecting IGF-1 LR3 into the CC every other day. The idea behind this is that after some stress on the internal erectile tissue of the CC the IGF-1 will bind the CC smooth muscle and prompt smooth muscle enlargement. The thought here being that this will result in bulkier erectile tissue inside the CC and create even more expansion during erection, which will lead to even more growth. Stagestop said that he felt the IGF-1 was primarily good for girth, but it seems to me that 3-dimensional expansion will result, assuming this works at all.
This is still really experimental. I’m not sure how many people have tried and stuck to this program on this board. But there have been reports of success, both in published results from experiments, and anecdotally on this board (and supposedly on others, thought I’m not on them).
I myself seem to have topped out in the results I can get compared to how much effort I’m willing to put in for other modalities. I think I reached my limit on ligamentous lengthening and now am focused on tunica enlargement. I think this is slower, but has much more potential for continuous gains over time, and the chemical approach, while challenging, is essentially passive relative to the duration of the ‘workout.’ I don’t have to sit in a chair with weights hanging between my legs for hours a day, for example.
So for me, this is an approach that makes sense. After years of using different modalities to varying degrees of success but essentially incremental results either because of my physical limitations or limitations in making an ongoing intense effort, this is likely my last attempt at a sustained effort to enlarge significantly. If it works for me, I’ll let everyone know. I’d love to get the results that stagestop did, but even a percentage would be worth it to me.
If you, or anyone else reading this, is interested in this approach, then please do read stagestop’s thorough reporting of his MD-guided experience. It’s super long, but the clarity, warnings about potential dangers, endless answering of questions and clear reporting of benefits, risks and limitations are all there. It is worth reading the whole thing (well, nearly the whole thing. The last couple of pages kind of devolve after he stops responding some years after the first post).
Also, you really, really have to know what you are doing. Honestly, one should have the guidance and support of an MD for the PGE-1 compound use. There are some big risks if you don’t know what you are doing and you can really injure yourself permanently. There are cases of men who have to go to surgery to repair their penis from priapism that went on too long, and this most likely leads to permanent deformity and dysfunction. Infection is another risk. Some guys have tried to mix their own injectables from cheap online sources of the PGE-1 powder and had big problems. There are other risks, like scarring and Peyronie’s disease that can result. The list goes on. Like any medical procedures, there are risks and benefits, and the risks here are extremely small if you know what you are doing, but not so much if you are winging it.
Please consider this a warning label for my thread. I might point back to it to any future reader so there is a clear-eyed understanding that this isn’t just something you try without a LOT of background work and deep thinking, especially if you are new to injections, needles, penile physiology and anatomy, etc.
My plan is to update on my process regularly, both as a document for my own journey, and, hopefully another clear description of this process (I really admire and appreciate stagestop’s thread and hope to contribute one along the same lines in terms of future value).
My approach is one-minded but the reported results have been mixed. So I’m ok with it not working, but if it does, I’ll let everyone know how it goes and then people can make up their own mind as to if it is worth the effort or not for them.
2 more.questions
Are.you in the medical field?
How did you get a doc to go along with this approach to obtain meds and guidance to get a larger dick. Im sure that conversation may be met with skepticism?
Goal 7.5 x 6.5
Start 4/22 6 x 5.25 BG
Current 11/22 6 x 5.5 BG 4-7/8" MG
This is really interesting!
When you say fatigued from a 7 hour erection, how ones that feel? Are you constantly stimulating to maintain it or is it purely from the injections and just an irreversible hard on only to be lessened with the other injection ?
I had surgery once on my D and I remember the doctor injecting me with something that resulted in rock hard EQ to ensure his stitching was right. Must have been something similar
The erection intensity varies a bit, and goes up and down bit at times related to visual or physical stimulation and at other times is just ongoing and self-perpetuating. This might mean the difference of 80% (barely bendable) and 100% (nearly painfully tight). As others have reported, it can be a weird erection. You can have a 100% CC erection with no CS erection. So your CC’s are ballooned out and rigid and your CS and head are soft. It’s weird. This seems to happen when not engaged in sexual stimulation. The CS and head expand as usual with sexual excitement.
This is because the CC essentially a closed space, limited by the tunica. The injection causes the vessels in the tunica to dilate and the dilatation causes increased blood flow into the tunica. This, in turn, clamps down on the draining vessels, so the blood can’t escape. This is a simplified explanation of the physiology of an erection. The difference between a chemical erection and a regular one is that the blood flow dynamics don’t vary when you stopped being turned on. They go until the drug wears off. The CS is not surrounded by a rigid structure so the blood can flow right out whenever stimulation decreases.
This physiology is why dosage is so very important. If you stay erect too long, the blood trapped in the CC gets viscous and start to clot and the tissues start to die from lack of fresh blood. There’s a lot of debate as to how long is safe, but the risk of this is reported to be minimal under 8 hours. I don’t see any reason to push it past 3-6 hours though. Plus, as many have reported, it’s not exactly comfortable.
The tunica fatigue feels like a mild soreness. I’ve had this from clamping. The most intense soreness is where the clamp was compressing the tunica, but I’ve also felt along the rest if the session was intense. I’ve less of this with heavy hanging, but for me the hanging was targeting the ligaments.
You probably had this kind of injection. If there is suturing to do on the inner connective tissue of the penis and not just the skin then expansion helps to both make the suturing easier and more functionally appropriate. Getting the surgical patient to have and maintain an erection during a procedure depends on PGE-1 injection. Unless maybe your surgeon is super hot and talks dirty the whole time ;)
Rock out with your cock out!
2 more.questionsAre.you in the medical field?
How did you get a doc to go along with this approach to obtain meds and guidance to get a larger dick. Im sure that conversation may be met with skepticism?
Disclaimer: In answering your simple questions, XL, I typed out a response that started to get longer and longer, and more and more a general perspective on this approach. I guess I feel a sense of responsibility to make sure that anyone who reads this thread is aware of what injecting medications into the penis can do if you aren’t well-educated or prepared. So please don’t take this response as an answer to you, though you might find it interesting or useful. I’m going on about this in case someone reads this down the line who gets excited and jumps into action on it before knowing what they are doing or getting into. Sorry if I sound like Chicken Little. I don’t mean to sound condescending.
In response:
I am in the medical field. So I definitely have a leg up on doing this stuff. I also have a keen understanding of the risks, which is why I go on a bit about having professional guidance.
I don’t recommend going to a doctor asking for help with chemical PE unless the doctor advertises that as an offering. If you read stagestop’s thread you’ll see that he found a Canadian doctor who offered a chemical PE protocol. (I cannot recommend that thread highly enough if you are interested in this approach. It is a must to read it from beginning to end.) The thread is so old I have no idea if that doc is still practicing, but there might be others.
If you can’t find such a PE-supportive doctor and there is an interest in chemical PE (remembering it is even more experimental than other kinds, and almost certainly has more significant risks) one might consider asking a doctor for a PGE-1/Trimix prescription to help with sexual function. It is a common ED prescription. Some people are totally healthy and yet have psycho-emotional ED and that’s why they can use it. Some may not respond well to oral ED meds, or have issues with side effects from them like severe nasal congestion or pounding headaches, making them unpleasant to use. Each person’s conversation with their doc will be different in terms of discussing why injectables are of interest.
There is no guidance that requires that injectables be the last line of medication intervention, though most people don’t like needles, and some docs might be hesitant to prescribe, either because of inexperience or the idea of the liability of sending someone home to stick a needle into their penis and risk serious problems is hard to justify when most people just want to pop a little blue pill that will definitely wear off before its a problem.
So if your general doctor doesn’t want to prescribe, or isn’t comfortable, then you might seek out a urologist. This is a common urology issue and the urologists are likely to be extremely comfortable with prescribing to most patients.
Typically you have to go into the office for consultation and get test injections to see your response to the dosing. They target a shorter duration that is meant for sexual intercourse, like 30-60 minutes. They also want you in the office to teach you appropriate, clean injection technique and how to handle the vial and syringe.
I’d also recommend getting a prescription for injectable phenylephrine and have a couple of boxes of pseudephedrine pills on hand as an antidote. I’ve already used injectable phenylephrine twice to reverse my Trimix erection, both times at around 7 hours. It’s no joke to be at the 7 hour mark and unsure of how long this might go on. Going to the ER for this seems like an embarassing and expensive nightmare, especially if you can medically reverse it almost instantaneously with another injection. Which is all the ER doc is going to do anyway in the first 24 hours.
So definitely need to get a doc on board for both the prescription and education components. More than worth the time and money if you intend to do this, IMO.
Once again, this stuff is easy if you have pharmacy grade meds and know what you are doing. Hundreds of thousands, if not millions, of men have used injectable ED meds for years and years under a doctor’s supervision and never have a complication.
But it can be catastrophic if you cut corners and inject who-knows-what that you bought off the internet or did home chemistry to mix or if you put needle into a vascular or nervous structure that messes you up or if you get an infection in the deep tissues of your penis or if you have a priapism that isn’t reversed in time.
I get the IGF-1 LR3 from an online peptide supplier. It is not prescription as it is sold for research purposes and not labelled for human use. No doctor can prescribe it but the injection technique is the same so once you know how to do it right from a trained professional you can use the technique to inject that you learned for PGE-1/Trimix. The IGF-1 LR3 does not cause an erection. Think of it as a PED for smooth muscle bodybuilding the CC inner tissues.
Rock out with your cock out!
Tenacious (or anyone else that has had to subdue a chemical erection):
I know phenylephrine shots are the “antidote” to an overly long lasting erection and what you used in your episode, but I’m wondering why even inject another substance? Since you’re already jabbing your CC again to inject the phenylephrine, why not just aspirate some blood out instead?
Am I missing something? I’ve done it once before with success but really want to see what the prevailing wisdom says.
So you aspirated blood to reverse an erection? Just out of curiosity, what kind of needle/syringe set up did you use and how much did you aspirate to have the desired effect?
I don’t have any experience with blood aspiration for this, so I’m just spit-balling. But the Trimix instructions from my compounding pharmacist don’t talk at all about aspiration but medications to reverse it.
Plus the American Urological Association guidelines on the management of acute, non-ischemic priapism as a result of intracavernosal medication injection state that first line therapy is intracavernosal phenylephrine injection. It’s also first line for ischemic priapism, with aspiration (with or without irrigation) as a second or combined therapy.
In terms of why I think phenylephrine injection is probably better than blood aspiration as a first line at home, a few of reasons come to mind:
To aspirate sufficient blood to reduce an erection would likely require a large gauge needle, particularly if the blood is a little viscous from stasis. (Plus a tiny needle is easy to clog with aspirated tissue.) Assuming one could aspirate much at all with a fixed 30G needle, the syringe is only 1cc. So either significantly more tunica trauma (and pain) from a bigger needle with a larger syringe or not much blood evacuation with a smaller, safer needle. Big needles seem like a recipe for fibrosis. Or at least significant tissue trauma. Plus you would probably have to have a syringe preloaded with some sterile water to inject in to clear the needle tip. You kind of have to know what you are doing.
Aspiration itself will cause some local tissue trauma to the CC sinusoidal tissue. Any time you put a vacuum through a needle tip there is local trauma. There is little if any local tissue trauma upon injecting fluid into a potential space through a small gauge needle. I’m not sure if the amount of tissue trauma is meaningful, but why not avoid it altogether?
Finally, even if one evacuates blood, if there is still an ongoing vasodilatory effect from the PGE-1 then the erection will just come back. Perhaps the deinflation/reinflation introduces enough fresh blood to stave off tissue death, but seems to me that if one is going to the effort of putting a big needle in to evacuate blood then its probably time to be done with the session. The benefit of phenylephrine is that it counteracts the effect of PGE-1.
So to me, the safest, simplest method is just to inject a little phenylephrine when it is called for. Large volume blood aspiration would be more for a dire emergency when the phenylephrine fails, not first line treatment. At that point I’m probably headed to the ER.
One can also take a few oral pseudoephedrine, which I have on hand and considered, but that is a systemic dose rather than local. It’s less invasive, to be sure, but it is also less of a guarantee of working. The recommended dose of pseudoephedrine for priapism reversal is pretty high and taking a bunch of Sudafed late in the day is like drinking a bunch of coffee before bed. Since the phenylephrine injection is just as simple as the Trimix injection it seemed the way to go and I had a good result that built my confidence about this process.
To be clear, the plan is not to need phenylephrine again now that I have dialed in the dosage. But it is good to have on hand if, for some reason, there is an unexpected increased response to the dose or an accidental overdose.
Rock out with your cock out!
Speaking of dialing in my dose, tonight I dropped the dose from the other nights and injected 0.4mcg of Trimix. I got about a three hour erection, with the 90+% duration of about 90 minutes. I did have to do more stimulation to maintain it at 90% or above at this dose. And the remainder kind of required me to stimulate to have it fluctuate between 75% and 90%.
So I think my sweet spot is 0.5mcg. But better not quite enough than too much.
I manually stretched for a total of 35 minutes today, 20 just before injection, along with DMSO and 10 minutes of ultrasound heating.(I just received the ultrasound machine I recently ordered and used it for the first time tonight.)
After I was up I spent a total of 30 minutes in a heated pump at 5 inHg. I packed the 2.25 inch diameter tube much more than usual at this duration and vacuum level (somewhere between half and 2/3 of the shaft length) and was up about 0.5 inches in length inside the tube compared to usual. When I came out of the tube after the last set there wasn’t more subcutaneous edema than typical so it does seem to be related to expansion of the inner structures. Not sure if this increased volume in the tube is related to the the ultrasound warming I did for the first time or related to the injections over several days having a cumulative effect on collagen softening. I don’t think it’s indicative of actual permanent growth but it seems a positive sign.
Despite less duration of intense erection level and a shorter total erection duration than on the previous nights, my tunica is again pretty fatigued/sore. If that is an indication of anything (which I can’t actually say it is yet) then it was a good session. So its useful to notice that even a shorter, less intense session has a positive indicator in that way.
Since coming down I’ve spent about an hour in my extender and plan on another hour or two before calling it a day.
Rock out with your cock out!
I did another 1.75 hours in my extender. During the use I used ultrasound warming for 20 minutes. It resulted in a noticeable increase in pliability and length in the extender.
I know there has been a lot of intelligent experimentation with US heating for results and based on my first experience I can see how effective it might be. Again, we’ll see if it translates to permanent results over time, but it definitely feels like it might be beneficial.
Rock out with your cock out!
I did another 1.75 hours in my extender. During the use I used ultrasound warming for 20 minutes. It resulted in a noticeable increase in pliability and length in the extender.I know there has been a lot of intelligent experimentation with US heating for results and based on my first experience I can see how effective it might be. Again, we’ll see if it translates to permanent results over time, but it definitely feels like it might be beneficial.
Dumb question.
If using chemical PE at several hours having an erection, why not with a pump or a clamp for several hours or so?
I clamp about 30 min and could probably pump fpr an hour at -3hg.
I guess the chemical route is like all efforts, set it and forget it (not really).
Im starting to think as.long as ypu have good PI’s, the best routine is the max you can do every day but not so much your dick wont get hard.
For me that thin line of too much vs. Not enough has taken some time to figure out, but the strategy is my question. Thoughts?
Goal 7.5 x 6.5
Start 4/22 6 x 5.25 BG
Current 11/22 6 x 5.5 BG 4-7/8" MG
Dumb question.If using chemical PE at several hours having an erection, why not with a pump or a clamp for several hours or so?
I clamp about 30 min and could probably pump fpr an hour at -3hg.
I guess the chemical route is like all efforts, set it and forget it (not really).
Im starting to think as.long as ypu have good PI’s, the best routine is the max you can do every day but not so much your dick wont get hard.
For me that thin line of too much vs. Not enough has taken some time to figure out, but the strategy is my question. Thoughts?
My theory, for what it’s worth, is that Trimix (or similar) causes expansion internally outward against the tunica, versus pumping (for example) that is all an external "tug". True that clamping must also be an internal to outward pressure, but in my experience the very distinct discomfort that can be induced via Trimix, especially with gentle added pumping (that I think causes even more blood to flood the CC to stress the tunica from within), makes it seem as though the tunica is stressing outward from within. Its a unique feeling, not necessarily pleasant, and care must be exercised. I have also applied a cock ring while using Tri and that can also amp-up the internal pressure. I would caution against any clamping effort though as the erection is (or can be) like stone.
My thoughts are the same as Newyorktexan. I’ve tried many, many techniques over the years, and one of the benefits described about chemical PE is the ratio of intensity to passive effort when compared to hanging clamping or manual exercises. A 2-6 hour intense erection can be had while being otherwise productive, as long as it’s discreet. Its like it combined the benefits of and ADS with intense focused exercise.
Thanks to NyTxn I am also adding in a bit of low pressure pumping to increase tunica expansion, which is pretty passive as well, though not 100% so since one has to monitor the pressure gauge and restart the process every so often, at least if you don’t want to do one long session but several shorter ones.
I enjoyed clamping, a lot, and got some short term results, but in the end I couldn’t make it a regular, ongoing practice since I got so much skin discoloration. I found it weird to have 3/4 of my dick a different color than the base, where the clamp was. No discoloration with the Trimix, even with pumping, since it is pretty low pressure. That’s another plus.
I’ve not yet used a cock ring. I can see where that might keep things intense during the phases of the Trimix erection that wax and wane a bit. I’ll try that tonight. Thanks again NyTxn!
Rock out with your cock out!
In answer to the PI question from XL, I haven’t noticed any decrement from adding the Trimix. In fact, they’re opposite ( but keep in mind I’m on TRT and daily Cialis 6mg, as I’ve previously mentioned.)
Otherwise my routine is pretty minimalist: total of 30 minutes manual stretching and 30 minutes low pressure pumping. Anything additional is based on my circumstances allowing and me feeling like adding it. The hope for the Trimix is that it is the secret sauce that makes a minimalist approach as or more effective than a lot of dedicated effort.
We’ll see if I can add something to the accumulated experience on this topic.
Rock out with your cock out!
adding in a bit of low pressure pumping to increase tunica expansion, which is pretty passive as well, though not 100% so since one has to monitor the pressure gauge and restart the process every so often, at least if you don’t want to do one long session but several shorter ones.
Search the aquarium pump thread. A $25 pump, a screwdriver, an aquarium valve, and some 1/8" hose and tee fittings, and you have a constant vacuum source.
Mine has well over a thousand hours on it without a hiccup; I need to update the hour count sometime.
30 minutes of manual stretching today.
Injected 0.5mcg of Trimix. Resultant 5 hour erection at 90% or above. Essentially detumescent at just under 6 hours. Did three 10 minute pumping sessions during the erection at 5 inHg. This time used a near IR heating pad during the pump. Like last night, packed the 2.25 inch tube more than halfway up the shaft. Tonight I was just under 8 inches in the pump, which has happened in the past but never at such a low pressure. Like others, I’ve noticed I’m usually shorter in the tube than my BPEL. I did get a bit more edema today. Not sure why but the near IR was way hotter than I am used to achieving with a normal heating pad.
The five hour erection was a challenge. It’s pretty uncomfortable after about 2 hours. I saw a case series study in another chemical PE thread where the subjects had significant increases in length and girth by using a 6 hour erection target, so as uncomfortable as it is, I think it makes sense to shoot for 4-5 hours rather than 2 hours on many, if not most sessions when I have the time since the difference is only only 0.1mcg between 2-3 hours and 5-6 hours. Which seems crazy that such a tiny amount could nearly double the response, but now there is enough data to increase my confidence about it.
I also learned during this session that masturbating to get deflation doesn’t work and, in fact, has the opposite effect. I was on the way down at about 3 hours and I thought it would complete the process, but getting fully hard again seemed to restart the clock and I had another two hours of nearly 100%. This is the second time it happened for me like that. So if I want to be done I need to leave myself alone. If I want to go a little longer, then stimulation works really well to make that happen.
I injected 10mcg of IGF-1 LR3 in the same syringe as the Trimix. I wasn’t supposed to inject IGF today, but I made a mistake and didn’t double check my spreadsheet. So I’ll skip it tomorrow.
Added 30 minutes in my extender so far. I have a few more hours to go before bed, so I’ll probably a bit more time, but I’m not going to push the tension too much. My poor guy feels pretty beat up at this point…
Rock out with your cock out!
Session yesterday:
Total of 35 minutes manual stretching with US.
0.5mcg Trimix with resultant 5.25 hour 90+% erection. Pumped four 10 minutes sessions at 5inHg during the erection with NIR.
Once subsided did 105 minutes total in extender.
That is 7 days of Trimix in a row, with a total 90+% erection time of 19.25 hours. Now that I have a reasonable idea of dose response I can titrate a bit between 3 and 6 hours, though the difference in amount is so small I can’t be precise. I’ve been injecting IGF-1 LR3 for almost 3 weeks.
I’m definitely walking around a lot thicker and longer (with no superficial edema) but I can’t yet tell if that is just training effect of daily PE lingering or if there is some actual intracorporal increase.
I’m going to hold off on officially measuring until I reach a month of Trimix. That will be the beginning of August.
Just injected for today, both IGF-1 and 0.5mcg of Trimix with the expectation of 4-6 hour session.
I think I’ll start to post updates a bit less frequently on this thread now that I have the hang of things and there are no significant changes in my program planned for the time being. I’ll update at intervals or if something meaningful to document or share arises.
Rock out with your cock out!