Giving chemical PE a try

Hey, all.

Been on and off the board for years. One break was so long I lost all my login info and had to create a new account with a ‘2’ on the end.

Still doing some finalizing research but here is the plan:

Trimix 3-4 days a week with 2 hour erection as the target.
IC IGF-1 LR3 10mcg 3-4 days a week.

30 minutes manual stretching 5+ days a week. Considering supplementing with topical DMSO for stretching.
Two 10 minute pumping sessions at 5 inHg 5+ days a week.

I won’t get started until sometime next month, once all the supplements and meds arrive.

I’ll begin a diary once I get started.

A bit about my journey:
I’m in a happy second marriage with a super supportive wife. We have a great sex life. My interest in PE has been around for years, and one of the obstacles for long-term consistency is that I’m not exactly small (though I’m not huge, either) which makes the grind sometimes hard to maintain. Also the typical issues with other life priorities getting in the way.

This time I am going to make a plan to continue through a predetermined set duration for my efforts. Now that I’m a bit older, life is more stable in every way and I have more time on my hands I can add a PE routine to my other healthspan/bodybuilding routines that have heretofore taken precedence.

I don’t have a goal. My wife is extremely tall and has a beautifully tight but accommodating vagina. There are only a couple of angles where I can drive too deep and usually only when I’m about to orgasm and am at my most erect. Otherwise I can pound away at a reasonably thick 7.75-8 inches BP, depending on the day. Also my mid-shaft girth is >0.5 inches smaller in circumference than the base, and she can take me easily in terms of girth all the way in.

I don’t know what an upper limit might be in terms of what pleases her, but its mostly for me, and out of curiosity of how much a larger penis might please her. I suspect I could gain an 1-2 inches in length and 1-1.5 inches in girth without limiting our current sexual enjoyment. I plan on keeping an eye on how she responds and will back off if things get tricky.

Based on Stagestop’s results over a year with his trial of chemical PE I plan on giving it 3-6 months as a start and will see if the gains come and if they are enduring. After that, if there is progress, the wife is enjoying and I can handle it, I’ll keep going.

Otherwise I’ll just go back to occasionally partaking in some PE for the fun and health of it, as it seems to bolster my libido and fun with sex, even if I’m not consistent enough to make big gains.

Hello Tenacious, and good luck. You may find some helpful experiences in my progress reports. I undertook a multi month course of PRP and self injected Trimix. I found, among other things, that pumping (gently) while turgid from the Trimix seemed to impact the tunica, or at least that’s what I ascribed to the discomfort. It was an interesting experiment.

Thanks for reaching out. I’ll check out your report.

My meds and supplements are on the way. I’ll be doing intracavernosal injection with Trimix (with 10mcg/mL concentration of PGE-1) every other day (EOD), and intracavernosal injection of IGF-1 LR3 10mcg EOD on alternating days.

Thanks to some postings by others (including longtimer) I’ll be adding oral PABA 1000mg three times a day (not POTABA, which is the potassium version of the same active ingredient and requires prescription). I’m adding this because it is used to both prevent the possibility of tunica scarring/possible Pyeronie’s and because there are case reports of significant growth along with PGE-1 injections from what must be some collagen softening.

POTABA/PABA is used as a first line therapy for Peyronie’s and has been used to soften collagenous hardening of the skin in some other diseases, like scleroderma. Plus, anecdotally, some people say it helps with thicker hair and prevents hair from graying, so, why not?

I also got some DMSO for topical application, as it might also help soften collagen. I’ve never used it but if the reports of causing transient bad breath happen to me and I can’t tolerate it, I might discontinue it.

My initial measurements on uploaded and I’ll report back on how it goes once everything arrives in the mail.

Here we go!

Before you proceed much further I recommend you to take a blood sample few hours after the first shot confirming you actually got IGF-1.

Thanks for the tip, Kyrpa.

I feel pretty confident about the Trimix, as I’m receiving it from a legitimate compounding pharmacy from a physician’s prescription.

Just to document for myself and others, unrelated to this journey, but possibly having some effect on it, I’m on:

Longstanding weekly injections of testosterone cypionate for TRT. My levels are high normal to just above. I inject twice a week rather than once to smooth out the levels.

Finasteride 1.25mg per day to defend against hair loss. I realize this might be counterproductive but I’ve been taking it for years, starting when I first noticed some thinning at the crown. I’ve been fortunate to keep my hair. Also no experience of evident prostate enlargement based on normal urination. Normal PSA. I’m not going to think about topical DHT until or unless I don’t get results. Then I might consider it short term while on this regimen.

I’m also taking the growth hormone secretagogue peptides CPC-1295 300mcg and ipamorelin 300mcg subcutaneously Monday-Friday.

Received 10mL of Trimix with 10mcg PGE-1 per mL in the mail today.

Just so happened also to receive three 1mg vials of IGF-1 LR3 in the mail today from a separate provider.

Trimix went into the freezer, per the compounding pharmacist’s direction. He said to freeze it between uses to make it last longer than I’ll need to, as it degrades in the refrigerator. Because of an upcoming trip I’m going to wait until July to start my incremental titration of dose. I plan to start with 1mcg (0.1mL) and titrate up to 2.5-3 hour duration.

Also going to wait a bit to get started on oral PABA, which arrives tomorrow, so that will be on board when I start PGE-1 injections.

I reconstituted the IGF-1 LR3 with sterile 0.6% acetic acid solution. I will inject this along with 4x volume of bacteriostatic water to dilute the acetic acid and increase injectable volume for better intracavernosal distribution.

I think I’ll start the IGF-1 LR3 this afternoon after my weight training. I’m going to start with 20mcg rather than 10 for the first couple of weeks and then back off. I’m thinking this will give me a running start on increasing intracavernous smooth muscle volume before starting PGE-1 since there are reports of about a month’s delay between initiation of IGF-1 LR3 and noticeable results.

I’ll update accordingly.

I did that, but after a year I moved to subcutaneous using 1/2" insulin syringes, every other day.

It takes a while to fill the stringes through the tiny needles. Warming the testosterone cypionate up first helps. My prescription is two vials per month; I load two weeks’ worth of syringes at a time and put them in a sandwich bag, ready to use.

Injecting more often is supposed to give you more bang per milliliter. I can’t tell any difference, but it’s a lot easier to do a small skin pop than it is to jam a 1-1/2" needle into my leg.

Gosh, I’ve been injecting my glutes and shoulders for so long I’ve not considered subcutaneous delivery. Thanks for the tip, AndyJ. I’ll do some research.

After doing some research, and before full embarking on chemical PE, I’ve decided to stop my oral finasteride and replace it with topical finasteride (along with minoxidil) to combat any potential for hair loss.

I’ve been on finasteride for 15 years, and TRT almost that long, so I’ve probably never had the full experience of the systemic DHT effects of the TRT. My sex drive is already sky high, and I’m relatively muscular, so it will be interesting to see if there is any noticeable difference.

Along with the potential improvement in my chemical PE efforts (though this is still not definitive with DHT), I’ve had some waxing and waning, intermittent , mild gynecomastia with TRT. I’ve never been able to figure out why this would happen, since my dosages have been stable for so long. I’ve used arimidex and tamoxifen to treat, but now I wonder if it has been because my DHT has been suppressed.

So that’s why I’m switching from oral finasteride to topical. Although there is some data that there could be DHT suppression with topical finasteride use, several studies seem to indicate that, depending on dosage, it might be minimal compared to oral use.

Official exercise regimen for the first 3 months of this endeavor:

50% topical DMSO application
2-5 minute rice sock warm up
30 minutes manual stretches split into as many sessions as required (this is minimum and I’ll do more when possible and am moved to do so).

50% topical DMSO application
2-5 minute rice sock warm up
Two 10 minute pumping sessions at 5-6 inHg. Can increase session length or duration when I can and want to do so. Evening session will often be in the sauna, so no need for rice sock in that case.

That’s it for exercises. In the past I’ve gotten to obsesses and things became unwieldy and unbalanced. So I want to see if I can have a positive result with a minimalist approach.

I described the chemical approach in prior posts, but for my own future reference in one post:

Trimix EOD with dose titrated to achieve 2-3 hour erection
IFG-LR3 10-20mcg EOD
DMSO topical with each session of PE exercise
PABA 100mg TID

Incidental but possibly meaningful:
Testosterone cypionate for TRT ongoing
CJC1295 and ipamorelin 5 days a week for HGH elevation.
Switching to topical finasteride. Oral finasteride ended today.

I forgot to mention that I also take Cialis 6mg every day.

Interesting note: after DMSO usage for 4 days along with my minimalist routine I’ve increased 1/8" BPFSL, now at 8 1/8". No extra pull effort and no tip swelling from training to account for it. It seems apples to apples comparison. Further, I typically only reach 7 1/4" length in the pump, and this evening I made it to 7 3/4" at the same pressure as usual. I’m also noticing extra flaccid length and girth just walking around.

Routine erection after a little stimulation (as opposed to rock hard super turned on) is no change, still at 7 7/8".

I’m not sure if it’s meaningful yet, as it could just be a little post-layoff bump after getting back to a routine, but I’m wondering if it might indicate that I’m more pliable from the DMSO. It’s way too early to relate to the PABA or IGF-LR3.

Excited to get started with Trimix in about a week and see what happens.

Hopefully a good indicator :)

Can you share where you get your dmso and what brand?