VEGF for chem pe, for angiogenesis new blodvessels

Hi,

I just stumbled upon an interesting thing, that could be good for growth. I just quote ronielle on this:

“In any case, since my research has lead me to the fact that the penis is a vascular organ, and is mainly made of smooth muscle cells, (by transitive property) angiogenesis occurs with penis enlargement. This may seem obvious now, but I actually did not link penis enlargement with the term angiogenesis. Going deeper is to study exactly what triggers blood vessel growth at the capillary level, and preliminary research suggests that it has mainly to do with a vascular endothelial growth factor (VEGF).

Getting back to the subject, angiogenesis creates more blood vessels (by definition), and more blood vessels mean more smooth muscle cells (SMC), which in turn means each new SMC has PGE-1 receptors. The total amount of PGE-1 receptors in the penis increases, which indicates that, to maintain the same intensity of erection as before the new growth, more PGE-1 must be injected to ensure adequate erectile response. Basically, drug tolerance is due to insufficient amounts of PGE-1 to activate the growing number of receptor sites in the penis, resulting in a continual increased dose of alprostadil (PGE-1) over time. The drug is not getting less effective, it just becomes not enough due to penile growth over time.”

That could be the pefect potentiator for penis enlargement. Theres a chemical site, that sells vegf for research purposes only

Here’s a study on rats with the substitution of vegf, which was at least successful in restoring erectile function..
Who knows maybe science will find some new solutions in a decade for generating new tissue..

But unfortunately breast enlargement for females is taken much more seriously than penis enlargement for men, which seems not to get quarter of that attention from medical professionals :(

http://www.natu re.com/ijir/jou … l/3900943a.html

Even if it could help there’s a big risk regarding accelerating atherosclerosis by VEGF, so do you want a dick that can’t reach it’s max because of the plaques in your arteries ?

http://www.atherosclerosis-journal.com/article/S0021-9150(06)00447-3/abstract

Sorry, but this scientific article is a bit difficult to read for me.

As far as I know, alprostadil also leads to an increased level of vegf and it is not known to cause plaques in the arteries, more of the opposite. If you have arterial problems, it can solve them

Wouldn’t doing edging and PE increase these factors internally and naturally?

Another protein of interest is FGF-1 or fibroblast growth factor 1

http://www.asia andro.com/archi … -682X/8/543.htm

How come it is difficult ?

The study examined serum levels of VEGF and made a positive association between that and progression of atherosclerosis.

Also , the study noted : “Male smokers’ serum VEGF concentrations were higher than non-smokers’. “
We all know , smoking must be the “best” thing for Erectile Function.

I know it would be some interesting thing if it would help in the way we would like, I once made a little research on VEGF and also on it’s association between it and VIP, but I remember that even if it theoretically could help, there are still many drawbacks.

But if you would still want to try it keep us updated, maybe we can come with a handy idea.

Subscribe this question.

Well edging is hard for me personally, because if you cum, than it makes no sense. But if you can and your eq is good, I am sure edging increases these factors naturally as you said. There is an Asian urologist and healer, who used this on patients successfully. He told them not to masturbate at all and stay abstinent for more frequent erections, and in his study, which unfortunately I dunno what link it was, he had in most patients better erectile function and some enlargement aswell. I personally have to have some discipline for myself, not to jack off for weeks and maybe months. I really believe this can help and at least heavy masturbating is bad for the penile tissue, because you have your penis than almost always in a flaccid state

That’s also an amazing substance, thanks for these good links mate. The science is all around right now on genetics & tissue engineering etc. But it just seems that no scientist is able or willing to put those concepts together to a succesfull manner for ed and maybe also enlargement treatments.
I think we have to re-emancipate ourselves as men, before we can expect to get enough scientific attention to that subject, but I’m sure the whole multi-billion $ penis enlargement industry who’s profiting from poor desperate men, who fall for their bullshit products, would also stand in the way of such an important progress aswell. I think we need to change the system, before we can get a scientific method for that case. It’s time for a phallic revolution ;)

@Alin: English isn’t my first language, that’s why it’s difficult for me. About trying it out: it’s all theoretical now and I won’t try injecting vegf in my cc. Even if I would want to try it out, I wouldn’t know where to get VEGF or even how to use it.

@Dw: I found a FGF-1 Creme, which supposedly leads to collagen growth of new cells, but I don’t know if it’s bunk though and it’s pretty expensive.
E’shee Clinical Esthetic - Serum Cellular Repair Gene Therapy, stem cell serum for wrinkle reduction and skin repair

Here’s a cheaper one of pure human recombinant fgf-1 from china, but as usual with Chinese stuff you never know what’s actually inside..
http://www.made -in-china.com/s … th-Factor-.html

I also stumbled upon EGF which seems to be at least as interesting as FGF-1:

[Usage]
EGF is a highly efficient cell division factor with many biological effects, which mainly includes:
Stimulating the growth and proliferation of skin, cornea and racheal epithelium tissue in vivo.
Accelerating the healing process of epidermis damage on skin, cornea, etc.
Accelerating the proliferation of epithelial cells in human and animals.
Facilitating the bio synthesis of protein, RNA, DNA as well as metabolic activity in epidermal cells.
Reduce and prevent lines and wrinkles by actively generating new skin cells.
Whiten skin tones with full of vitality and energy.
Eliminate scars on skin by forming new skin cells.

http://www.made -in-china.com/s … th-Factor-.html

The science is spread all-over, we just need some scientific effort from professionals, but I don’t think that’s gonna happen too soon.

Edit: my question to you is, do you think that FGF-1 is effective transdermally?

PS: A scientific article on "angiogenesis promoters": Angiogenesis promoters - Welfide Corporation
Too difficult to read for me, but maybe someone will get something out of it

@ Amar7
(1) I totally agree on your idea of edging - I’m pretty sure it contributes to building up a solid level of beneficial hormones (especially testosterone and DHT), whereas ejaculation takes it down, together with a good chunk of protein precursors and cell energy (ATP) otherwise used to maintain, repair and grow the tissue. That’s at least my understanding of it.

(2) About no "scientist" combining all those chemical goodies - the idea (even if rather vague) is there and even in the process of being patented. Check out the other threads on chemical PE, especially this one:
Chemical Penis Enlargement

(3) Topical application of beneficial chemicals - I personally strongly doubt that any creme, ointment or massage oil whatever with a percentage of let’s say 5% of the active agent, be it FGF-1 or whatever, will get enough of it through the cell pores of the skin and further through the tunica tissue, unless the molecule structure is both resistant and small enough and/or trans-dermal carrier is used. Even then the effects of topical application on skin are rather systematic than punctual. I see not much difference in a subcutaneous injection of substance x and the trans-dermal application of substance x at about a 10 times higher dose. Chemically penetrating the tough tunica tissue however is a whole different story. There wouldn’t be any use of auto-injections if topical or subcutaneous application of a higher dose of the same agent had the same (or even nearly the same) effect. Even intra-urethral applications are not sophisticated enough to actually get an exact dose of a chemical agent into the corpus spongiosum.

Ok. Now, no one has ever posted ever the smallest evidence of gains achieved only by edging. There you go with all this ‘science’.

And I think the supposed scientist that claimed that abstinence can make your penis bigger is the notorious Dr. Lin - should I add more?

That’s not exactly the meaning of my words.

Marinera, yes dr. Lin is his name. He might be fraud I didn’t do research on him, he just seemed to be legit on first sight to me. Maybe the enlargement thing is not possible with abstinence, but I am convinced, that the erectile function and penile health gets elevated, if you don’t masturbate or only rarely. It worked for me personally, when I had low erections, they came back after abstinence from ejaculating

@DW: 1) You got the point, and that’s how I see it aswell. It’s useful to see this aspect for overall penile health to say the least..
2) Dr. Adams has that patent for a long time already doesn’t he? And AFAIK his patent doesn’t contain vegf, EGF and FGF1 for that matter. There are also many other genetic growth factors out there, who he doesn’t state in the patent. The only thing he mentions, is IGF-1. I also bet there are some other ingriediences, which he found to be successful and not stated in the patent aswell as there are ingriediences which he knows to be useless, which he has written in the patent to distract anyone who wants to use this method aswell. His main thing is comercial interest unfortunately and not really serving the patients as it looks to me.
Just about the vasolidator he states to get an errection about 4hours and most people can’t even stand the pain for one hour only. I’ve read that he mixes some painkiller to the vasolidator, to get that prolonged erection without the pain

3) I know about molecule size and transdermal carrier like DMSO has to fit and that a transdermal absorption is never the same as injection, even if the molecule is small enough to penetrate the skin. But I wouldn’t dare to be the lab rat and inject some FGF-1 in my CC to be honest