The plateau , in other terms the diminishing or completely stopping growth has stayed the biggest question mark on PE. There is no reasonable and conclusive solution available for out coming this.
Some have managed to continue gains in some degree after they have taken extended times off completely from the PE activities. For some even long absence have not offered any help.
Why the growth stops even for great gainers and never recover follows the same laws that regulate natural growth or the bodybuilders reaching the level no longer gaining muscle.
In PE discussion the reason for the diminishing gains have usually been pointed on incomplete collagen remodeling. If it were all about that every penisbuilder would be gaining like big-gainer newbie every time after taking 2 years off from PE.
It is easy to find out, it is not that simple, there is lot more into it.
I try to put it in short term, and I believe not having the ability to even describe all in details.
I have been lately mentioning to an exhaustion about mechanotransduction, mechanosensing and residual stress etc. The newest science has been trying to solve the mechanics of regulation of growth still not having the conclusive answers or accurate formulas.
The consensus is within the scientific field that the evidence is pointing for the cellular pressure having a major role on limiting the growth.
Naturally growing tissue, and more precisely any organ after reaching certain level of ECM pressure and there for the cellular pressure being transferred by the mechanotransduction will stop the growing.
At this pressure the organ then keep its form if there is no major external compounds affecting it.
Tissue extracellular matrix put under the stress, in our case stretching it, forms equal to the external forces internal stresses, which are transferred through the ECM complex to the fibroblasts. These force sensing cells start to signaling the growth responses leading in to easing the internal stresses by profileration and re-organizing the ECM .
The ECM trying to reach the homeostasis in to new stress level environment. To make it more complex the homeostasis is not only reached for the displacement, strained and elongated tissue but for the stressed tissue as well. If we keep exercising without gains the internal pressure still keeps on accumulating despite the gains being absent. The ECM adapting to the stress level.
This works both ways as with the external forces no longer present the ECM tries to find the homeostasis at the no- loaded state.
As a consequence of the abusive external stress or in best case residual strains, in other terms permanent lengthening, the unfortunate side product of the tissue growth is the residual stress on the ECM.
According some literature, despite the profileration and remodeling processes maturing the cellular and the structure settling for the new size, the cellular pressure seem to stay at the elevated level limiting further growth.
I previously presented one mathematical modeling based estimation of the accumulation of the residual stress and the powerlaw basis decay for it. It is a robust presentation of the importance of the decon breaks. If the model were to be realistic the residual cellular stress should take more than a decade to downgrade back to the starting level cellular pressure. Which was the time having 67% smaller unit almost two years ago.
Being accurate or not the model shows the ugly reality the more we gain and the longer periods we
exercise not having extended breaks, the more guaranteed it is that there are no future gains available.
If I were as educated on this subject as I am today I would have taken at least 3 months decon breaks after
every 60 to 70 days gaining periods I had.
Now the focus is on extinguish the on going fires. Something needs to be done for trying to “reset” the
ECM by somehow intervening the residual stress recuperation.
I have been thinking of ways to shake this homeostasis somehow and reboot the cellular stress.
There might be some chemicals available but I don´t want to take that route.
ESWT has been studied for the last two decades from different intruding angles on healing tendons and
ligaments.
LIPUS has been studied on healing soft tissue damages and since I already had two machines capable for
produce such a treatments I will take an advantage of it.
Since both of the methods are used for treating light to mediate erectile dysfunctions as well I don’t
hesitate to ulitize these treatments.
Using even the Light Energy Shock Wave Therapy (Li-ESWT ) it will cause microdamage on
cellular level. What is the cellular damage exactly remains unknown but the studies on ESWT indicate that
the level of damaged cells is proportional to the amount of shocks used per treatment. And there is always cells
destroyed. That we can call as a literal shock to the ECM. On the one hand but also an increased expression of
different growth factors associated with regeneration processes. There remains a balance between teh destructive and rebuilding processes.
So looking for the disorganizing collagen degradation causing tool for ‘rebooting’ the ECM you have it.
“ESWT treatment of healthy equine tendons would lead to adverse effects on tendon matrix in the short
term, indicated by histologically visible disorganisation and increased gene expression levels for the
proteolytic matrix metalloproteinases (MMPs) 3 and 13.”
”Repair promoting effects may take longer to occur and, therefore, it was also hypothesised that the total
collagen content and the expression of genes coding for the major ECM components collagen types 1 and 3
(COL1 and COL3), as well as the gene expression for MMP14, a mediator of collagen remodelling, would be
higher 6 weeks after treatment.”
https://beva.on linelibrary.wil … -weYIC2374FV3Ep
Light Intensity Pulsed ultrasound (LIPUS) has been found to promote cell motility through cell to
ECM adhesion which to me signals for the possible release on cellular pressure.
Though the studies are in -vitro studies and the academic level of these is astronomical, but if there is a
chance and I will take it.
Now completely another thing is the ED aspect both of these treatment forms provide, both are found to
be promoting for example angiogenesis, neo-vascularization, NO-production, Nos -pathways etc.
Interestingly in animal models LIPUS has been found to enhance smooth-muscle to collagen ratio and
elastin content on cavernous tissue as well.
The evidence found from the several studies with ESWT telling me to use the most effective way on treating ED with as less shocks as possible will be the principle. Using less shocks with higher energy pulses at the start and soon after decreasing the shock energy to the ED therapy level .
For using the LIPUS in conjunction I can keep the ESWT use in minimum and using the LIPUS known for minimal adverse effects in greater volume.
For setting the "new standard" for ECM residual stresses fixed length extender is used for keeping the unit near the BPFSL dimension without tension during and after treatments.