The Holy Grail of PE is found!!!

WHat’s a guy got to do to acquire some of your tomatoes xeno?

Be my neighbor :D

ModestoMan & others — A couple studies that may have been posted here in the past and are both interesting:

Study 1

INTRODUCTION: Recent evidence suggests that blocking inducible nitric oxide (NO) synthase in the penis may exacerbate fibrotic processes and that application of medications known to increase NO in tissues may prevent fibrosis. AIM: To report the use of an antifibrotic regimen consisting of medications known to upregulate NO production in two patients with refractory priapism. METHODS: Two patients presented with priapism of greater than 48-hour duration. After corporal aspiration/irrigation and shunting procedures failed, both were prescribed a daily antifibrotic regimen comprising the phosphodiesterase inhibitors pentoxifylline and sildenafil, and the NO precursor, L-arginine. RESULTS: At 1 year, both patients were found to have supple corpora without evidence of corporal fibrosis. CONCLUSIONS: An antifibrotic regimen consisting of upregulators of NO production may ameliorate the corporal fibrosis associated with recalcitrant priapism.

Study 2

Sildenafil citrate (Viagra) is widely used for the treatment of erectile dysfunction with various etiologies. The aim of the present study was the investigation of histopathological effects of sildenafil citrate on rat corpus cavernosum using tight and electron microscopical techniques. Twenty male rats were divided into two groups. The first group (n = 10) was used as a control and the second group (n = 10) was treated with sildenafil citrate. Penile tissue was collected, fixed with formalin and embedded in paraffin for light microscopy, or fixed with gluteraldehyde and osmium tetroxide and embedded in Epon for electron microscopy. Light microscopical analysis showed that the corpus cavernosum was elongated and the number of blood vessels was increased. The amount of connective tissue in the penis was increased and dense collagen and smooth muscle fibers were observed in treated rats. Electron microscopical analysis showed that stromal structures of the corpus cavernosum (collagen fibers and number of cellular elements) were increased in treated rats. Fibroblasts showed signs of activation and the number of other stromal cells was increased. Immature newly synthesized collagen fibers were observed and penetrated endothelial basement membranes. In addition, endothelial cells also showed signs of activation such as cytoplasmic granules in treated rats, whereas the surface area of blood vessels was increased and basement membranes were thickened. These histopathological changes due to treatment with sildenafil citrate indicate that prolonged use of sildenafil citrate may increase the risk of fibrosis in the penis.

I read in a Norwegian newspaper that having erections for a longer period of time can cause Gangrene (tissue death) in the penis, witch leads to amputation.

I also found this “article” about the dangers with Penis enlargers and erection maintaining rings;

Quote:
“Prolonged use of the rings may cause gangrene of the penis”

Man…I leave you guys alone for a few days…and look what happens!

Glad to see its settled down and gone back to discussions on how to grow us some “beefsteak dicks”…now thats some TOMATO!

With regards to the 2 studies posted by Para-Goomba , does it basically mean L-Arginine is good .. Keeps the tissue supple , & Viagra is bad as it may toughen the penile tissues ?

Too many big words for me to understand lol .

Some opinions?

Oh, and, 340, 360 are just relative numbers, they dont have to be taken as they are.

I have this weird “Been there, done that” feeling.

heh

Regarding study 2, Maybe this really is the holy grail of PE?

Correct me if I am wrong here, Their dicks grew from using Viagra?

The conclusion from the study seems to be that there is an increased risk of fibrosis, If that is the case then there could also be an increased risk of fibrosis from doing PE exercises and gaining from them? Because of the new tissue we are building? Or maybe PE would decrease the risk of fibrosis?

Elongated corpus cavernosum, Increased number of blood vessels, Increased amount of connective tissue, Increased number of cellular elements and collagen fibers… = Bigger dick?= Increased risk of fibrosis?

Reminds me of a friend of mine, He has been using Viagra a lot (for a few years) and we were talking about the effects of using Viagra when he suddenly says that he believes his dick is getting bigger because of the Viagra.
I actually tried to bring it up with him again a while ago but he didn’t`t answer, He just smiled.

Could be worth a try, 30-40 mg of Viagra 3-4 times a week?

I lot of big words for sure. The two studies contradict each other. The first concludes that increased NO2 from Sildenafil as positive effects. This study only looked at two patients. Both Sildenafil and arginine were used to increase NO2 in the tissue, so I don’t think you can differentiate the benefits of sildenafil from arginine from these studies.
The second study said Sildenafil MAY have negative effects. This study was on rats, not humans. Both are interesting but I would not hang my hat on either as being definitive.
The study I posted a while back, that Modesto referenced, looked at 34 men with ED who took a Viagra every night whether they needed it or not (compared with 2 other groups, those that took it only for sex, and those that did not use ED drugs). 20 out of the 34 men reported they no longer needed Viagra to have sex after 1 year on this regimen, and the effects seemed to be long lasting, at least 6 months after the regimen stopped.

I would call that a big leap of faith. Those tissue changes could mean increased total mass of tissue, or could just mean a change in composition of the tissue.
A rat study is not nearly as good as a human study. And looking at histological changes under the microscope and making conclusions of whether or not those changes are positive or negative, is also a little shaky.

Yes nick, I think you are on the right track.

I know there are guys on the forum who are chronic ED drug users. Anybody remember who they are? It would be useful if we could get some of them to chime in.

“Elongated corpus cavernosum” Sounds like a length gain? Maybe I am misunderstanding something here but it sounds like an increase in size to me? Yes it is rats and the results could be different with a human study, Would just be great to find something that would actually work along with the PE routine.
Taking Viagra 3-4 times a week doesn’t sound to risky to me.