Gaining volume with Kyrpa

Yes, all the exercise benefit from the elevated temperatures.

This is the minimum set up for reaching core temperature 40C threshold at best, but not much more .
Operating in the threat of having skin burns if not careful.

You have found the way ,it is really great to see you gaining with moderate loads also! Keep on hammering!

As beardeddragon once said, nobody owns this information. It is free for all to do what ever they want with it. So I don´t mind at all.

Lots of things we are stating have been pondered around for decades. But for some reason even being discussed , many aspects have simply not been studied in practice and have been poorly documented at least. I think for instance that first mentions for ultrasound have been from 2002, so there have been some knowledge already, that it is the only way reaching the the core temperatures needed for greater things.
First and last stress strain curves I have found goes back to 2005. And this I found to be very sad and stupid , that the basic picture what is happening have been ignored for decades. There have been some pioneers describing things as they happen of course, but the lack of documentation have caused PE community to dismiss a lot of things.

For the processes involved I would rather take a opinion after seen the whole progress, the timeframe when it diminishes in the longrun. But there are many increased activities signaling need for growth I suppose. There is on going restructuring of collagen process and the adaptation of the collagenous matrix for sure. Adaptation on new length achieved not to stress used to achieve it.
Temperatures are allowing processes otherwise reached only with un-tolerable loads and much longer timeframes.
There are limitations concerned within collagenous remodeling time requirements but the whole IPR scenario, I would doubt it being involved.

Maybe some day real professors find out some of our documentation and bring it down to the lab. Until then it is just a case of better guessing.
I really am not in to producing theories business, I am for growing dick business.

I do have an access in university library. But the majority of the references seen here are available in some form all over the web.
Many of them usable studies have been posted and referenced here, starting from 2002 already.

Clamping in a hot bath tub with US and a aluminum foil reflector on the opposite side to bounce the waves back into the tissue could be optimal for clamping.

Have you taken a look at the NKISK papers? There is about 3-5 papers if you search. The results are quite remarkable. I think it explain what is happening with the fibrils. They are not breaking or rupturing, they are simply sliding past one another. This is possible because the fibrils are discontinuous. They have a finite length.

The more interesting thing however is that NKISK was shown that when injected into tendon against control creep/strain was attained in the range 10-20% over control. The way it works is NKISK replicates the Decorin-fibronectin binding site and by binding to one side of the site it blocks decoring-fibronectin binding and thus lets collagen fibrils slide past one another.

NKISK is simply a pentapeptide, a small chemically synthesized peptide of 5 amino acids in the sequence Asparagine (N)-lysine(K)-isoleucine(I)-serine(S)-lysine(K). It is like insulin, in the sense that it is composed of amino acids, but much much shorter. Insulin has 51 amino acids. So it is quite "natural" let’s say, as it is just injecting amino acids in a PBS solution (which is a buffer to keep the PH at around 7.4 and compatible with bodily fluids).

The greatest length was achieved in a rat patellar tendon, which measures 8.8mm, by injecting 50mM NKISK in PBS solution in a 1ml volume once a week for 4 weeks. Then the rats were killed and the tendons loaded. 20% strains over control were achieved, which is p<001 statistically significant of course. However, there were strains over control of 10-13% just with 5mM of NKISK injected daily for 7 days. Thus there is a dependency on the dose of NKISK on the strain achieved, as well as the volume of the injection ( this means the tendon is more saturated and the solution can encompass it better if the volume is higher).

I am thinking in a 20cm dick, a ligament (cord) not including the head, of 15cm, split into 8.8mm segments, would require around 8 injections of 50mM NKISK for each side. Can you imagine a 20% strain it would be around 4cm!

So hypothetically, as it is not for human use, as it is not approved by the FDA or deemed safe, to that effect, one must at least use 5mM per day or 50mM a week, or anything in between in 8 places on your dicks cord. 1ml is quite a bit of volume so perhaps one can reduce it to half, to 0.50ml, otherwise you are injecting 8ml at once to your cord, which seems like a lot, but perhaps with experimentation it isn’t.

Because NKISK is a custom peptide it is quite expensive. I’ve reached out to various labs and at one lab, the cost was for 100mg of NKISK it is $360. For 1000mg it is around $800. This is only for research purposes, and not for use in humans, as many other anabolic steroids like testosterone and HGH peptides are.

With 100mg one can make eight 0.50ml injections of 21mM NKISK. Ideally, if one could afford $800 they could make much more, enough to be able to replicate the 50mM weekly injection in 8 places, for 4 weeks, and see if one could obtain the maximum benefit.

Calculator: Molarity Calculator | Molarity Triangle | Tocris Bioscience
M. Wt of NKISK is 588g/mol

Other agents that have achieved the effects of NKISK are Relaxin, Polylysine, Gentamicyn, and Tobramycin.

However:

Polylysin is KKK, a tripeptide, but it does not replicate the decorin-fibronecting binding site, so it probably inhibits binding less than NKISK. NKISK is not perfect either, as the exact sequence is not found out yet that perfectly inhibits this binding, but it is estimate that there is 70% inhibition. With KKK probably less than 70%. However, KKK is only 3 aminos, so it is going to be around 3/5 of the cost of NKISK, as the custom peptide lab charge per AA.

Gentamicin and tobramicin are antibiotics so that is out of the question for me.

Relaxin is the hormone excreted when women give birth and it helps to stretch the uterus and ligaments in the pelvis so the baby can be born. It is quite expensive, and the one you would want to try is relaxin 2. It is synthesized using recombination with the e.coli bacteria, and one can obtain about 25ug of it for $250. Relaxin had same effects as 1mg of NKISK by using 46 units/ml of relaxin, which with 25ug you can make about 70 units/ml. The calculation is quite complicated. But relaxin has been shown in studies to promote cancer growth aggression if there is cancer present, so that scares me a bit. Also, for relaxin to work, the target must have receptors. We are not sure penile ligaments have relaxin receptors. But apparently patellar tendons in rats do, so there is that.

The risks…. The risks of injecting NKISK or KKK is unknown, although there were no side effects for NKISK over the 4 weeks in multiple rats, over the long term we don’t know. Because it is a small peptide of just 3-5 aminos, it is not a lot I would think. I definitely don’t encourage the use of it as it is "illegal", as all these other peptides like HGH and IGF-1, unless it is for research purposes. But I think this can be groundbreaking for PE.

If we can inhibit the binding of the fibrils, we can much more easily stretch this cord.

Sorry for the long post, the main thing was how these fibrils are sliding past one another. Maybe not lengthening, maybe just sliding past their finite lengths. And perhaps both.

I’ve made a new thread if anyone wants to follow the above:

NKISK pentapeptide, the HOLY GRAIL of PE?

I am trying to get some input from practitioners who may have some insight into the use of peptides and their safety to see if it would be a viable method of PE.

I have to say that injecting anything in ligaments, TA or septum would be demanding task. Injecting 8ml would be undone. If the substance have systemic effects and could be injected in CC, then it would be doable.

Perhaps we are somehow bypassing, or at least reducing the inflammation response and going straight to cellular proliferation?

Having reached viscous properties with heat and moderate stress, within relative moderate strain percentages, therefor producing less damages on tissue, this could be the exact case.

Congrats, amazing gains! At this rate you’ll reach 10 inches by the end of next year. :D

There are only couple of guys (undocumented) here who have gained faster than you, so obviously you are on the right track.

What is your real long term goal? I mean you can probably obtain any size you want in moderately short period time. 10/7? 11/8?

I have gained about 7.5 ci in 1 year and 9 months (if I have measured correctly) but you have made over 8.5 ci in a bit over a year.

FWIW I don’t think there is cell proliferation without inflammation. And I think there needs to be a differentiation between treatment that causes edema versus that which triggers proliferation induced inflammation.

Thank you and congrats to you then, those volumetric figures are just great.

No I won´t , more likely I will reach it year later :) .This of course looking from the charts, the reality is completely another thing.
At the moment my longterm goal is leave this experiment at eve of the 2022. With as much dick I can possibly carry. Maybe even sooner.

I would be pleased with my size already, if I could reach my girth goal. Secondly I would like to learn how the girth gains are truly found.

If only we were to know. If we were does it change anything? I am comfortable not knowing. Observing reactions to actions and seeing some progress is all we need to know in the end.
Hopefully someday there are some clinical studies explaining it all. But we will be long gone with our huge dicks already.

Thought I would give you guys an update on my first month of Ultrasound facilitated PE.

The month started off great, and my first day using a modification of Kyrpa’s routine I hit over 6% elongation. I have provided my data for this month attached here. However, I quickly got derailed and frustrated - on day 3 I got a huge blood blister from using too much vacuum/strain with my newly acquired Penimaster Pro and had to stop for 9 days to allow healing.

I have decided that my glans just doesn’t like too much vacuum on it. I have done different ADS systems in the past, and even at lighter forces I still would get bruising from time to time. I tried several different ways to protect the glans, thanks everybody for the recommendations, but any extended period of time at the forces used by Kyrpa, and the higher forces Manko and others, created too much trauma. Its a moot point anyway because I now use and love the Bib Hanger hardcore, thanks for that Manko. I was able to use it right away, and I think I got lucky using the 3M Coban wrap, because it allows me to fixate my fella and pull any weight I need to without injury and minimal discomfort. I did get some redness on the tip of the glans, but it seems to be getting used to it.

My initial routine (sessions 1-9) was 30 minutes 3-4kg of stress relaxation, followed by 2 10 minute with US. 2W, 100% feed rate using saliva as the transmission media. I would do cyclic manual stretching doing cool down for about another10 minutes and did this for 9 sessions. My results seemed to be diminishing, so I added an extra session of 10 minutes of US on sessions 10, 11 and 12. That bumped my elongation % up again, and I feel that 30 minutes is the sweet spot for me. If you have read my prior posts, I was making no gains for almost a year, I think my ligaments are just super tough from adaptation of many prior years of PE (hence the incorporation of US and starting PE again). It just takes more heat to get things loosened up than the average guy.

So my new routine is this: (did this last 3 days)
(1 set) 30 minutes stress relaxation 3-4kg
(3 sets) 10 minutes US 6kg, with cyclic stretch at the end of each 10 minute session after removing the heat while everything is nice an warm. I do 5 pulls, 7kg, 8kg, 9kg, 10kg, 11 kg 15 seconds ramp up, 15 seconds at max stretch, then 15 seconds cool down. That adds about 4 minutes to each 10 minute US set.
(1 set) 10 minute Cool down at max elongation. This holds the collagen at its max stretch to hopefully maintain its new position.
So total workout time is 30 + 14 + 14 + 14 + 10 so about an hour and a half. Today I didnt have that much time so I only did 2 US sets, as in the beginning. Perhaps I will have “heavy” days and “light days”. Heavy being the 3 US sets plus cyclic stretching, and light being less than 3. I’m thinking maybe only 2 heavy sets per week. I’ll have to see how my gains go.

I will continue to use this over the next month to see what happens. BTW, I attached a hook to a stud in my wall and pull straight out or even slightly upward, compared to hanging which pulls down. I have an inline digital fishing scale permanently fixed to show my force during my workout.

It is counterintuitive to me not to do any ADS after my workout, but I am going off of Kyrpa’s routines and the science presented by he and Manko and the results they have been getting without ADS wear after. I will continue to do similar to what they have done, and see how it goes over the next few months. I think using US is a different animal. I believe that US is stimulating favorable collagen orientation, accelerated cell proliferation and healing, and that ADS wear after perhaps is not necessary.

I’m still getting used to both wearing the Bib Hanger as I have only worn it 9 times so far. I am also getting used to doing US therapy.

I can say that my unit feels thicker and more vascular after just 12 sessions logged for August. I’m super pumped, literally, and am excited for continued gains.. Its almost as if I’m a “newbie” again. If thats the case with US - allowing continued growth indefinitely - that would be a huge step forward in PE. There will be alot of guys with big dicks terrorizing the streets. Only time will tell - I’m only a month in, 12 sessions and even taking a week and a half off, my results are encouraging. Almost 1 cm of increase in resting pre workout BPFSL1, and 5mm increase in post workout BPFSL2.

Hope this information is useful. Cheers, DocJ

We don’t know. But that said I have no reason to think that we are doing anything but deciphering an effective proliferative response, within normal limits. I too am comfortable not knowing, what I am not comfortable with is thinking we are unlocking some heretofore previously unknown proliferative response. And I am not intimating that you are suggesting anything of the sort.

Great results Doc, are you seeing progress with your BPEL also?